Clinical trials: Fat Disorder
Transgender, Gender Identity
The Effects of Orchiectomy and Age on Vascular and Metabolic Health in Older Versus Younger Transgender Women
This study plans to learn more about differences in heart disease risk after gender-affirming orchiectomy (i.e., testes removal) in older transgender (trans) women compared to younger trans women.
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT05195164
- Testing
- No intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypercholesterolemia
The Occurrence of MACE in Patients With AMI Receiving Pitavastatin/Valsartan Treatment
Prospective Observation study to identify the rate of MACE in AMI with Livalo V(Pitavastatin/Valsartan) for 12 month in Korea
- Trial name
- LAMISIII (NCT04270344)
- Testing
- Pitavastatin 4mg
- Where
- South Korea
- Volunteers
- 905 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
Chronic Diseases
A Cluster-randomized Controlled Knowledge Translation Feasibility Study in Alberta Community Pharmacies
Background: Despite evidence of benefit for pharmacist involvement in chronic disease management, the provision of these services in community pharmacy has been suboptimal.
- Trial name
- NCT02191111
- Testing
- Task-focused facilitation
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy Participants
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics With AZD0780 Following Repeated Dose Administration in Healthy Adults With Elevated LDL-C Levels
The purpose of this study is to evaluate pharmacodynamics (PD) of AZD0780 compared with placebo by assessment of low-density lipoprotein-cholesterol (LDL-C) levels following repeated oral dosing in healthy adults with elevated…
- Trial name
- NCT07423598
- Testing
- AZD0780
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Dyslipidemias
Fatty Acid Biomarkers of Carbohydrate Intake
The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
- Trial name
- CARBIO (NCT03295448)
- Testing
- Low carbohydrate diet, High carbohydrate, high sugar diet, High carbohydrate, low sugar diet
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cardiovascular Diseases, Hypercholesterolemia
Guideline Adherence for Heart Health
This study addresses the challenges associated with implementation of clinical practice guidelines (CPG's) and is motivated by our interest in gaining insight regarding the following general research questions about CPG…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- GLAD Heart (NCT00224848)
- Testing
- Palm-Pilot Intervention
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypercholesterolemia, Coronary Heart Disease
Phytosterols, Ezetimibe, and Cholesterol Metabolism
Phytosterols and ezetimibe each reduce intestinal cholesterol absorption by 30-55% but appear to have different mechanisms of action.
- Trial name
- Phyteaux-III (NCT00863265)
- Testing
- Ezetimibe, Phytosterols + ezetimibe
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Participants
A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy Adults
The purpose this study is to measure the impact of laroprovstat (AZD0780) on the pharmacokinetics (PK) of AZD4954 and the impact of AZD4954 on the PK of laroprovstat in healthy male and female participants.
- Trial name
- NCT07513571
- Testing
- AZD4954, Laroprovstat
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hyperlipidemia
Exenatide (Byetta ®) Regulation of Intestinal and Hepatic Lipoprotein Particle Production in Humans
Exenatide acutely inhibits intestinal lipoprotein particle production. We are unable to speculate whether exenatide affects hepatic lipoprotein production in humans since there is currently no evidence from animal models or in…
- Trial name
- NCT01056549
- Testing
- exenatide
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Familial Hypercholesterolaemia
The Spanish Familial Hypercholesterolaemia Cohort Study
SAFEHEART is a large, on-going registry study in molecularly defined patients with heterozygous FH treated in Spain.
- Trial name
- SAFEHEART (NCT02693548)
- Where
- Spain
- Volunteers
- 4,141 people, healthy volunteers welcome
- Sponsor
- Fundación Hipercolesterolemia Familiar
Flushing, Hyperlipidemias
Effects of Psyllium on Niacin Tolerability
The purpose of this study is to determine whether psyllium is effective in reducing flushing due to niacin and also to measure the effect of niacin on cholesterol levels.
- Conditions
- Flushing, Hyperlipidemias, Dyslipidemias
- Trial name
- NCT03370848
- Testing
- Psyllium, Aspirin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Adiposity
Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat
This is a phase I, open-label clinical trial evaluating the safety and efficacy of deoxycholic acid injection for reduction of upper inner thigh fat.
- Trial name
- NCT04054011
- Testing
- Deoxycholic Acid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dyslipidemia
Cardiometabolic Response to a Sodium-bicarbonated Mineral Water
The effects of consuming a sodium-bicarbonated mineral water rich in bicarbonate, sodium, chloride, lithium and silicon are studied in humans.
- Trial name
- NCT02480816
- Testing
- Mineral water
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Hypertension, Hyperlipidemia
The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians
In this randomized controlled trial, we will provide primary care physicians with free samples of highly effective generic cardiovascular medications.
- Trial name
- SAMPLES (NCT00761904)
- Testing
- Free Generic Samples (hydrochlorothiazide, simvastatin)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypercholesteremia
Phytosterol Supplementation and Cardiovascular Risk
This study examined the effects of 2.6 g/d of phytosterol ingestion on LDL cholesterol metabolism. It is expected that this dose will significantly reduce LDL cholesterol after 12 weeks of supplementation.
- Trial name
- NCT00153738
- Testing
- phytosterol
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Cooper Institute
Hypercholesterolemia, Hypertension
Effect of Amlodipine on the Lipid Profile of Newly Diagnosed Hypertensive Patients
In this study, Amlodipine has been used to study its effects in newly diagnosed hypertensive patients.
- Conditions
- Hypercholesterolemia, Hypertension, Cholesterol Deposition
- Trial name
- NCT05467384
- Testing
- Amlodipine
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ayub Teaching Hospital
Hypercholesterolaemia
A Study of PCSK9 Inhibitor AK102 in Healthy Subjects
This is a first-in-human,randomized, double-blind, placebo-controlled, single dose escalation, phase 1 study to evaluate the safety, tolerability, PK/PD and immunogenicity of AK102 administered subcutaneously in healthy subjects.
- Trial name
- NCT04169386
- Testing
- AK102
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Akeso
Obesity, Morbid, Bariatric Surgery Candidate
Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery
A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)."…
- Trial name
- NCT03419273
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Childhood Obesity Prevention, Childhood Obesity
Postnatal Exercise to Activate Baby's Brown Fat
The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk.
- Conditions
- Childhood Obesity Prevention, Childhood Obesity, Physical Activity, Lactation
- Trial name
- PEABaBy (NCT07467694)
- Testing
- Active group
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Metabolic Syndrome, Familial Hypertriglyceridemia
Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism
The purpose of this study is to determine whether chenodeoxycholic acid decreases de novo hepatic lipogenesis, hepatic fat content, hepatic triglyceride production and plasma triglyceride concentrations and improves hepatic…
- Conditions
- Metabolic Syndrome, Familial Hypertriglyceridemia, Familial Combined Hyperlipidemia
- Trial name
- NCT00465751
- Testing
- chenodeoxycholic acid
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
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