Clinical trials: Fat Loss
Obesity
Metabolic Flexibility and Metabolic Heath in Human Obesity
This interventional study explores the relationship between improvements in metabolic health following weight loss and changes in whole-body fat mass and its distribution.
- Trial name
- PROB (NCT07355933)
- Testing
- Body Weight Loss
- Where
- Chile
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jose Galgani
Bariatric Surgery Candidate, Protein Deficiency
Effect of Protein Supplementation on Fat Free Mass Preservation After Bariatric Surgery
This double blind randomized placebo controlled trial investigates the effect of protein supplementation on fat free mass loss in patients who underwent a Roux-en-Y gastric bypass.
- Conditions
- Bariatric Surgery Candidate, Protein Deficiency, Muscle Loss
- Trial name
- PROMISE (NCT05570474)
- Testing
- Protein drink supplementation
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- Maasstad Hospital
Obesity
Diet and Body Composition
The investigators hypothesize that differential dynamics in fat depots in response to two opposing dietary strategies mediate the beneficial metabolic effects during weight loss and regain phases.
- Trial name
- CENTRAL (NCT01530724)
- Testing
- Weight-loss diet strategy (+) exercise (PA), weight loss (-) exercise (PA)
- Where
- Israel
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Ben-Gurion University of the Negev
Obesity
GLP-1s to Enhance Lasting Optimal Weight
The goal of this study is to examine how tirzepatide affects body composition, bone health, and physical performance in older adults over a nine-month period.
- Trial name
- GLOW (NCT06861439)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Overweight
Effect of Nutriose Supplementation on Satiety, Weight Loss and Adiposity in Overweight Subjects
NUTRIOSE is a food ingredient defined as a carbohydrate polymer of vegetable origin (wheat starch or corn) with a degree of polymerization ≥ 3 and chemically transformed.
- Trial name
- ROQ_NUTRIMETAB (NCT01897662)
- Testing
- NUTRIOSE FB06, GLUCIIDEX 21
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Nealth Sarl
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Obesity, Weight Loss
Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers
Obesity is a direct result of food-intake in excess of body energy expenditure. Thus, induction of increased energy expenditure via the activation of thermogenesis at targeted anatomical sites can counterbalance obesity.
- Conditions
- Obesity, Weight Loss, Overweight and Obesity
- Trial name
- NCT03171415
- Testing
- RZL-012
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Obesity (Disorder)
Targeting Sedentary Behavior Reduction and Physical Fitness Enhancement in Women Before and Beyond Bariatric Surgery- BARIMOV Study Protocol
Introduction: Sedentary behavior (SB) and insufficient physical activity (PA) interact to worsen physical fitness (PF), obesity-related complications and diseases (ORCD), and all-cause mortality in women with obesity.
- Trial name
- BARIMOV (NCT07663942)
- Testing
- Sedentary behavior reduction program on physical fitness.
- Where
- Portugal
- Volunteers
- 72 people
- Sponsor
- Hospital de Sao Sebastiao
Obesity
A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®).
- Trial name
- COURAGE (NCT06299098)
- Testing
- Trevogrumab-Part A, Trevogrumab-Part B and Part C, Garetosmab
- Where
- 60 sites in United States, Puerto Rico
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Skin Aging, Transepidermal Water Loss
Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women
Evidences regarding the effectiveness of adipose-derived mesenchymal stem cells (ADMSCs) secretome to alleviate skin aging have been extensively available, yet no studies hitherto directly investigated the best administration…
- Trial name
- NCT05508191
- Testing
- Fractional CO₂ Laser, Microneedle
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shannaz Nadia Yusharyahya
Overweight, Obesity
"Improving Diet, Exercise And Lifestyle (IDEAL) for Women" Study
Diets all share the same principle: eat less energy than you need. This results in weight loss. However, the weight loss is usually a combination of a loss of body fat and muscle mass.
- Trial name
- NCT00710398
- Testing
- Exercise - Aerobic and Resistance, Dietary - Caloric Restriction
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McMaster University
Class I Obesity
Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study
This single-center randomized comparative study is designed to compare the effectiveness of tirzepatide and transcutaneous low-frequency auricular vagus nerve stimulation in adults with class I obesity and without chronic…
- Trial name
- TIFFANY (NCT07866183)
- Testing
- Tirzepatide, Transcutaneous auricular vagus nerve stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Weight Loss
Resistant Starch and Whey Protein on Energy Metabolism
Recent evidence shows that dietary supplementation with resistant starch (RS) increases fat catabolism and resting energy expenditure and decreases plasma insulin and glucose responses as well as the gut-derived hormone…
- Trial name
- NCT02418429
- Testing
- waxy maize starch, waxy maize starch and Whey Protein, Resistant Starch
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Hair Loss/Baldness, Alopecia
Autologous Adipose-Derived Adult Stromal Vascular Cell Transplantation for Alopecia
Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes.
- Trial name
- A-ADSVC-CT-A (NCT03427905)
- Testing
- Lipoaspiration, Transplantation
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Lebanese University
Obesity
Effects of Greenselect Phytosome® on Weight Maintenance After Weight Loss in Obese Women
This study evaluates whether supplementations with a highly bioavailable green tea extract may help obese women to counteract weight regain after a 3-month weight loss intervention.
- Trial name
- NCT02542449
- Testing
- Globes®
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Auxologico Italiano
Morbid Obesity, Metabolic Syndrome
Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.
The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Visceral Obesity
- Trial name
- NCT00431587
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Hadassah Medical Organization
Obesity
Diet Induced Weight Loss to Reduce Inflammation in Obese Women
Breast cancer is one of the most frequently seen cancers in the United States. It occurs at all ages but is particularly common in post menopausal women.
- Trial name
- NCT01699906
- Testing
- Diet regimen to induce weight loss
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Visceral, Diet, Healthy
Long-term Benefits of Abdominal Fat Loss in Abdominally Obese Dyslipidemic Patients (SYNERGIE Study)
The objective of this clinical trial is to verify whether the beneficial effects of weight loss on visceral fat measured by computed tomography and metabolic risk factors for coronary heart disease are maintained once high-risk…
- Conditions
- Obesity, Visceral, Diet, Healthy, Cardiometabolic Syndrome, Lifestyle-related Condition
- Trial name
- SYNERGIE (NCT06158191)
- Testing
- Lifestyle modification program
- Volunteers
- 186 people
- Sponsor
- Laval University
Diet, Carbohydrate-Restricted
Effects of Diet Manipulation on Women in the Curves Program
The purpose of this study is to look at the effects of a carbohydrate restricted, high protein, high fat diet on weight loss and health outcomes in women participating in the Curves Fitness and Weight Loss Program.
- Trial name
- Curves2 (NCT03093792)
- Testing
- Control, American Heart Association plus exercise, Curves Complete - I plus exercise
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cancer of Stomach, Cancer of Esophagus
GLIM-defined Malnutrition Criteria for Postoperative Outcomes in Patients With Esophagogastric Cancer
The present study aims to investigate the prognostic value of preoperative fat-free mass index for postoperative outcomes in patients undergoing esophagogastric cancer surgery, and to explore the role of the FFMI in the Global…
- Conditions
- Cancer of Stomach, Cancer of Esophagus, Malnutrition, Muscle Loss
- Trial name
- NCT05088304
- Testing
- no intervention
- Volunteers
- 205 people
- Sponsor
- Jinling Hospital, China