Clinical trials: Fat Reduction
Adiposity
Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat
This is a phase I, open-label clinical trial evaluating the safety and efficacy of deoxycholic acid injection for reduction of upper inner thigh fat.
- Trial name
- NCT04054011
- Testing
- Deoxycholic Acid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Body Fat Disorder
Impact of Oral Dyglomera™ on Body Fat and Blood Lipids of Overweight and Obese Adults
The extract of Dichrostachys glomerata (DyglomeraTM), has been reported to be effective in weight reduction in obese patients with metabolic syndrome.
- Trial name
- Dyglomera (NCT05483192)
- Testing
- Oral Dyglomera
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gateway Health Alliance
Moderate or Severe Submental Fullness
Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat
Phase 2 trial to evaluate the safety and potential efficacy of three concentration of polyene phosphatidylcholine injection (AYP-101) compared to placebo for the reduction of submental fat.
- Trial name
- AYP-101 (NCT03982225)
- Testing
- Polyene phosphatidylcholine injection
- Where
- 4 sites in South Korea
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- AMIpharm Co., Ltd.
Obesity
B195: Effect of Diet-Induced Energy Deficit and Body Fat Reduction on Inflammatory Markers in Obese Subjects
Aim: To dissociate the effects on plasma concentrations of the inflammatory marker c-reactive protein of a negative energy balance and a reduction in body fat stores.
- Trial name
- NCT00302926
- Testing
- energy restriction and maintenance
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity and Overweight
BK329 and Body Fat Reduction
This clinical trial aims to determine whether BK329 reduces body fat in adults with overweight or obesity and to assess its safety.
- Trial name
- NCT06628791
- Testing
- BK329
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Obesity
Study of Efficacy of a Probiotic and Postbiotic in Overweight and Obese Individuals
The study's main objective is to investigate the effect of a probiotic (live bacteria), postbiotic (heat-treated bacteria) on obesity parameters.
- Trial name
- Obelix (NCT05440630)
- Testing
- Probiotics, Postbiotic
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Body Fat Disorder
Non-Invasive Reduction of Fat in the Inner Thighs
Evaluate the safety and efficacy of non-invasive fat reduction in the inner thighs with the ZELTIQ CoolSculpting System.
- Trial name
- NCT01517659
- Testing
- The Zeltiq CoolSculpting System
- Where
- 3 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Subcutaneous Fat
A Phase 1 Study to Evaluate the Safety and Tolerability of CBL-514 Injection on Convexity or Fullness of Abdominal Subcutaneous Fat in Healthy Volunteers
The Phase 1 component of the study is a double-blind, placebo-controlled, single ascending dose (SAD) design intended to assess the safety, tolerability, and PK of CBL-514. The SAD part will involve 9 proposed dosing cohorts.
- Trial name
- NCT04699669
- Testing
- CBL-514
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Flanks Fat Reduction vs. Control
Fat Reduction in the Flanks Area vs. Control
Prospective, blinded, one arm, baseline-controlled clinical study for the evaluation the performance of the UltraShape treatment for non-invasive fat reduction by compare control and treated flanks.
- Trial name
- NCT02465775
- Testing
- UltraShape treatment
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Diabetes Mellitus Type 2, Heart Failure
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with…
- Conditions
- Diabetes Mellitus Type 2, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT06774014
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Skin Laxity
Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Submental Fat
This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive reduction of submental fat and skin laxity treatment.
- Trial name
- NCT05831332
- Testing
- BTL-785-7
- Where
- Bulgaria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Fat Disorder
Eon™ FR Clinical Study Protocol 1064
This study evaluates the treatment of subjects with the eon™ FR 1064 nm device in a single session to thermally induce apoptosis in adipose tissue.
- Trial name
- NCT03898830
- Testing
- eon™ FR 1064 nm device
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dominion Aesthetic Technologies, Inc.
Body Fat Disorder
Tissue Optimization on Cryolipolysis Procedures for Fat Layer Reduction
Evaluate the effects of tissue optimization before and during cryolipolysis procedures on the outcome of non-invasive fat reduction using the ZELTIQ System.
- Trial name
- TOPS (NCT01728857)
- Testing
- The Zeltiq System
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Submental Fat, Healthy
Long-term Follow-up Study on Safety and Maintenance of Efficacy of ATX-101
The investigation of the long-term safety and maintenance of efficacy of ATX-101 in reduction of submental fat.
- Trial name
- NCT02163902
- Testing
- ATX-101
- Where
- 15 sites in United States, Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Subcutaneous Fat
A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of CBL-514 Injection for Reducing Convexity or Fullness of Abdominal Subcutaneous Fat
The Phase 2a component of the study will be a randomized, open-label, parallel, and multiple dose study to further examine the safety and efficacy profile of 3 CBL-514 dose levels based on the results from Phase 1 of the study.
- Trial name
- NCT04698642
- Testing
- CBL-514
- Where
- Australia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Body Fat
Efficacy and Safety of Platycodon Grandiflorus Extract(GCWB107) on Decrease of Body Fat
This study was conducted to investigate the effects of daily supplementation of Platycodon grandiflorus extract(GCWB107) on decrease of body fat.
- Trial name
- NCT04023864
- Testing
- Platycodon Grandiflorus Extract(GCWB107)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Fat Reduction
Non-Invasive Reduction of Abdominal Fat
This study is being performed to reduce unwanted abdominal fat using a new applicator for the Zeltiq System.
- Trial name
- JUNO (NCT01101997)
- Testing
- The Zeltiq System
- Where
- 5 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Body Fat Disorder
Pilot Study of CoolTXT for Non-Invasive Fat Reduction
This study is being performed to reduce unwanted fat, in various body areas, using a new applicator and control unit for Zeltiq.
- Trial name
- NCT01517646
- Testing
- The Zeltiq System
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Fat Burn
Fat Reduction Induced by Magnetic Device - Ultrasonographic Evaluation
The study is a prospective multi-center open-label single-arm study. The subjects will be enrolled and assigned into a single study group.
- Trial name
- NCT03537716
- Testing
- Treatment with High Intensity Focused ElectroMagnetic system
- Where
- 3 sites in United States, Bulgaria
- Volunteers
- healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Body Fat Disorder
Pilot Study on the Submental Area
The purpose of this study is to evaluate the safety and feasibility of cryolipolysis for non-invasive reduction of submental fat.
- Trial name
- NCT01859091
- Testing
- The Zeltiq System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics