Clinical trials: Fat Sensitivity
Healthy
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity
The purpose of this study is to investigate signaling pathways in fat and muscle, as well as turnover of protein, sugar and fat after stimulation with growth hormone and during fasting in lean and obese subjects.
- Trial name
- NCT01299831
- Testing
- 72 hour fast, control, 12 hour fast, Growth hormone
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Resistance and Type 2 Diabetes
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise
Clearly the effects of diet and exercise are beneficial for obese persons, but the underlying mechanisms for the improvements in metabolic health are not completely clear.
- Trial name
- NCT00795860
- Testing
- Weight loss - diet only, Weight loss plus exercise
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fatty Liver, Nonalcoholic, Insulin Sensitivity
Determinants of Liver Fat Composition
Excessive fat in the liver, in absence of high alcohol consumption, is diagnosed as non-alcoholic fatty liver (NAFL). NAFL prevalence is as high as 50-70% in obese people and is associated with impairments in metabolic health…
- Trial name
- NCT03211299
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolism, Fatty Liver
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
- Trial name
- NCT00476879
- Testing
- Somatropin and pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Adults With Normal BMI
Fat, Inflammation and Insulin Resistance
The combination of impaired insulin sensitivity and insulin secretion is thought to be the basis of type 2 diabetes. Increased free fatty acids levels impair insulin action in muscle and liver, but also systemic inflammation…
- Trial name
- FIRE (NCT01054989)
- Testing
- Fat/Inflammation effects
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Sensitivity, Fat; Liver
Race Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity
This research study will examine how ethnic/racial background, body composition (%body fat), and the location of body fat affect the ability of the hormone insulin to promote uptake of blood sugar in persons who are 19 to 45…
- Trial name
- NCT03043235
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Polyphenolic Compounds and Metabolism
Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.
The proposed study aims to investigate that consumption of grape seed extract (GSE) would improve antioxidant status and impaired insulin action following consumption of a pro-oxidative high carbohydrate, high fat (HCHF) meal in…
- Trial name
- GSE2 (NCT01995643)
- Testing
- Active Capsule
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Overfeeding
Polyphenols and Overfeeding
Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus.
- Trial name
- Poly-Nut (NCT02145780)
- Testing
- 2g of grape polyphenol extract
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pre-Diabetes
Full-fat Yogurt and Glucose Tolerance
This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the…
- Trial name
- NCT03577119
- Testing
- Full-fat yogurt, Non-fat yogurt
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Obesity, Non-Alcoholic Fatty Liver Disease
Effect of Timed-Restricted Eating on Metabolic Health
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin…
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance
- Trial name
- TREAT (NCT06061042)
- Testing
- Early time restricted eating, Late time restricted eating
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Insulin Sensitivity, Weight
Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women
Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid…
- Trial name
- LCHF (NCT02005224)
- Testing
- LCHF diet and a bout of exercise
- Where
- Norway
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Atlantis Medical University College
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Menopause, Insulin Resistance
Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase
The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
- Conditions
- Menopause, Insulin Resistance, Body Composition, Beneficial
- Trial name
- NCT02076932
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fat Sensitivity
Saliva Modification Related to Fat Perception in Human
The perception of fat represents major scientific and nutritional issues. This research aims to identify salivary markers that could predict and possibly explain this perception in healthy human being.
- Trial name
- SensInFat (NCT01532778)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Obesity, Exercise
Exercise Training and Insulin Sensitivity
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans.
- Trial name
- NCT05930834
- Testing
- exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes, Obesity
PET Imaging of Regional Variation in Insulin Sensitivity of Adipose Tissue in Humans
The purpose of this research study is to use a relatively new technology, called Positron Emission Tomography (PET), to study how insulin works on sugar in your body's fatty tissue.
- Trial name
- NCT00222768
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sleep Disturbance, Postmenopausal Symptoms
Effect of Sleep Restriction on Adipose Tissue and Skeletal Muscle Insulin Sensitivity
Inadequate sleep is an independent risk factor for metabolic abnormalities (such as obesity, insulin resistance, and hyperglycemia).
- Conditions
- Sleep Disturbance, Postmenopausal Symptoms, Insulin Sensitivity, Cardiovascular Risk Factor
- Trial name
- SLEEP-IN (NCT04286451)
- Testing
- Sleep Restriction, Habitual Sleep
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center