Clinical trials: Fatigue Syndrome, Chronic
Chronic Fatigue Syndrome
Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue
Chronic fatigue is enhanced by adapted physical activity (APA) programs. Patients consulting on St Etienne hospital and suffering from fibromyalgia and long Covid benefit from a 4-6 week APA program, with 2 sessions per week.
- Trial name
- PAF-tVNS (NCT06170645)
- Testing
- APA program, Active transcutaneous VNS
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue
Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions.
- Trial name
- CLEAR (NCT07400848)
- Testing
- Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bern
Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME), Post COVID Syndrome
Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chronic Fatigue Syndrome and Post COVID Syndrome
This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and…
- Trial name
- NCT06978582
- Testing
- Mindful and conscious movement-based exercise, Conventional exercise
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- University of Seville
Post-COVID ME/CFS
Hyperbaric High Pressure Oxygen Therapy in Post-COVID Syndrome and ME/CFS
The objective of this observational study is to document symptom progression in 60 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) who undergo Hyperbaric Oxygen Therapy (HBOT) following COVID or other…
- Trial name
- NCT06118138
- Testing
- Hyperbaric oxygen therapy (HBOT)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), ME/CFS Following COVID-19
Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe, often infection-triggered disease characterized by debilitating fatigue and post-exertional malaise lasting over 14 hours, along with pain, cognitive…
- Trial name
- IMPACT (NCT07529197)
- Testing
- IA with TheraSorb ® column (Miltenyi)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Long COVID-19 Syndrome, Chronic Fatigue Syndrome
A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial
IRB approval date 14-APR-2024 and public at https://plataformabrasil.saude.gov.br/login.jsf since IURB approval Long COVID is a multi-systemic condition comprising often severe and persistent symptoms (longer than 12 weeks) that…
- Trial name
- REVIVE (NCT06128967)
- Testing
- Fluvoxamine Maleate 100 MG, Metformin Extended Release Oral Tablet
- Where
- 6 sites in Brazil
- Volunteers
- 399 people
- Sponsor
- Cardresearch
Cancer, Palliative Care
Therapeutic Touch in Cancer Patients Receiving Palliative Care
This study aims to examine the effect of therapeutic touch applied to advanced cancer patients receiving palliative care on sleep quality and fatigue severity.
- Conditions
- Cancer, Palliative Care, Therapeutic Touch, Sleep
- Trial name
- NCT07524179
- Testing
- Therapeutic Touch, Routine Palliative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Erzurum Technical University
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Post-COVID-19 Condition, Post-COVID Condition
Expanded Access Use of Human Umbilical Cord Blood (REGENECYTE) Infusion in Patients With Chronic Fatigue of Post-COVID Condition
REGENECYTE® (HPC, Cord Blood (Hematopoietic Progenitor Cell, Cord Blood)) for treatment in patients with post-COVID.
- Conditions
- Post-COVID-19 Condition, Post-COVID Condition, Post-COVID Syndrome, Long COVID
- Trial name
- NCT07332338
- Testing
- REGENECYTE®
- Where
- 2 sites in United States
- Sponsor
- StemCyte, Inc.
Post-Viral Fatigue Syndrome
Low-dose Naltrexone for Post-COVID Fatigue Syndrome
This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e.
- Trial name
- NCT05430152
- Testing
- Low-Dose Naltrexone
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Luis Nacul
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Stroke, Fatigue Syndrome, Chronic
Caregiver Burden and Psychological Outcomes in Caregivers of Stroke Patients With Lower Urinary Tract Symptoms
This cross-sectional observational study aims to evaluate caregiver burden, fatigue, sleep quality, and depression among family caregivers of stroke patients with lower urinary tract symptoms (LUTS).
- Conditions
- Stroke, Fatigue Syndrome, Chronic, Caregiver
- Trial name
- CARE-LUTS (NCT07480642)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Chronic Infections and Inflammation in ME/CFS: An Observational Study
CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled.
- Trial name
- CHIIME (NCT07227441)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
Fatigue is a prevalent symptom in patients with multiple sclerosis (MS) and is associated with considerable impairment in quality of life as well as loss of occupational capacity.
- Conditions
- Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progress Multiple Sclerosis
- Trial name
- NCT07426991
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in Germany
- Volunteers
- 837 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Fatigue Syndrome, Chronic
The Effect of a Self-Management Program in University Students
This study will be conducted as a randomized controlled pre-post test trial designed in accordance with the CONSORT guidelines. University students with chronic fatigue will be invited to participate; eligible participants will…
- Trial name
- NCT07455123
- Testing
- Self-Management Programme for Chronic Fatigue
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fibromyalgia, Chronic Fatigue Syndrome (CFS)
Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia
Fibromyalgia (FMS) is a chronic, multifactorial syndrome characterized by widespread pain, fatigue, and cognitive disturbances. This interventional study evaluates the impact of structured physical training using…
- Trial name
- NCT07242573
- Testing
- Physical Training Program, NESA X-Signal, Conventional Physiotherapy
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Breast Neoplasms, Musculoskeletal Pain
Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms
Breast cancer patients who receive endocrine therapy particularly aromatase inhibitors often experience aromatase inhibitors associated symptoms (AIMSS) such as joint and muscle pain along with stiffness and fatigue that can…
- Conditions
- Breast Neoplasms, Musculoskeletal Pain, Arthralgia, Musculoskeletal Diseases
- Trial name
- AIMSS-CARE (NCT07409948)
- Testing
- Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms (AIMSS-CARE)
- Volunteers
- 88 people
- Sponsor
- Addis Ababa University
Multiple Sclerosis, Diet Therapy
Investigation of the Effect of the MIND Diet on Disease Symptoms in Patients With MS
The planned parallel group, randomized controlled study design will be used to determine the effects of the MIND diet applied to MS patients on fatigue, quality of life, technological function and brain fog and to contribute to…
- Conditions
- Multiple Sclerosis, Diet Therapy, Body Composition, Randomised Controlled Trial
- Trial name
- MS (NCT07057999)
- Testing
- MIND Diet (Mediterranean-DASH Intervention for Neurodegenerative Delay), Traditional healthy nutrition program specific to Turkey
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Betul Uner
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany