Clinical trials: Fatigue in Multiple Sclerosis
Multiple Sclerosis
Bright Light Therapy for Sleep Disturbance in People With Multiple Sclerosis
Sleep disturbance is common in people with multiple sclerosis (MS) and contributes to diminished quality of life. Bright light therapy may be an innovative strategy to reduce sleep disturbance in MS, possibly through its effects…
- Trial name
- NCT04054050
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis, Treatment Adherence
Semi-inmersive Virtual Reality on Upper Limb in Multiple Sclerosis
Video games based on VR technology are emerging as valid tools used in neurorehabilitation for patients with neurological disorders, and as a low cost and easily accepted adjunct to traditional therapy.
- Conditions
- Multiple Sclerosis, Treatment Adherence, Upper Extremity Paresis
- Trial name
- NCT04171908
- Testing
- Conventional therapy, semi-inversive tech
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Multiple Sclerosis, Weakness
Effects of the Cross-Training in Patients With Multiple Sclerosis
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer…
- Conditions
- Multiple Sclerosis, Weakness, Fatigue
- Trial name
- CTSM (NCT02010398)
- Testing
- Cross-Training healthy subjects, Cross-Training multiple sclerosis, Standard-training multiple sclerosis
- Where
- 3 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Multiple Sclerosis
Study of Alternative Exercise Therapies for Progressive Multiple Sclerosis (MS)
This project will evaluate a new therapy for patients with a severe form of MS known as progressive MS. These patients are severely limited in their ability to walk and function in everyday life.
- Trial name
- NCT01097538
- Testing
- Body-weight supported treadmill training, Total body recumbent stepper training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Hicks, Audrey, Ph.D.
Multiple Sclerosis
Effects of Motor Imagery and Action Observation in People With Multiple Sclerosis
It was planned to examine the effects of motor imagery and action observation applied in addition to standard rehabilitation in people with multiple sclerosis on walking, fatigue, and trunk control.
- Trial name
- NCT05377476
- Testing
- Motor Imagery training, Action Observation training, standard rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Multiple Sclerosis, Fatigue Syndrome, Chronic
Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care
The main objective of the MS Boost study is to demonstrate the superiority of MSCopilot Boost over standard practice in reducing the impact of fatigue on Patients with Multiple Sclerosis (MS).
- Trial name
- MSBoost (NCT06386133)
- Testing
- MS Boost, Standard of care
- Volunteers
- 208 people
- Sponsor
- Ad scientiam
Multiple Sclerosis, Fatigue
Quantitative Fatigue and Muscle Performance in Multiple Sclerosis
Fatigue is consistently rated as the top symptomatic complaint for individuals with multiple sclerosis (MS). Currently, the MS Fatigue Impact Scale (MFIS), a subsection of the Multiple Sclerosis Quality of Life (MSQoL), is the…
- Trial name
- NCT02913209
- Volunteers
- 30 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Multiple Sclerosis
Repetitive Deep Transcranial Magnetic Stimulation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic-inflammatory autoimmune central nervous system disorder and a leading cause of neurological disability in younger adults in Western countries.
- Trial name
- rTMS in MS (NCT01106365)
- Testing
- H-coil (Repetitive deep transcranial magnetic stimulation)
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Running Title: Walking to Music and in Silence on a Treadmill
This work is embedded in the context of auditory-motor coupling, which entails the engagement of two systems; the interaction between the music (or repetitive auditory stimuli) and a walking individual (repetitive movements of…
- Trial name
- NCT04856345
- Testing
- Walking with music with synchronisation, Walking with music without synchronisation, walking without music
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Hasselt University
Multiple Sclerosis
Sleep Disorders in Patients With Multiple Sclerosis
Fatigue is a frequent and disabling symptom in patients with multiple sclerosis (MS). The pathophysiology of this sign is not fully understood. Some data suggest that the fatigue is associated with sleep disorders.
- Trial name
- NCT00137904
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Multiple Sclerosis, Relapsing-Remitting
Post-Authorization Observational Study to Evaluate Cognition and Fatigue in Relapsing-remitting Multiple Sclerosis (RRMS) Patients Treated With Rebif®
The study is planned to evaluate the cognitive functions in subjects with RRMS treated with interferon beta-1a, and its relationship to the fatigue and neurological dysfunction status.
- Trial name
- SKORE (NCT01075880)
- Testing
- Rebif (Interferon beta-1a)
- Where
- 13 sites in Czechia
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis (MS) - Relapsing-remitting
Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)
This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.
- Trial name
- ADVICE Phase 2 (NCT06884579)
- Testing
- Strength training, nutrition, and behavioral training, Self-Guided and Unsupervised Program with General Recommendations
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Almeria
Multiple Sclerosis, Breath Tests
The Relationship Between Mechanical Properties of Respiratory and Lower Extremity Muscles and Other Parameters in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease characterised by deterioration in the mechanics of the lower extremities and respiratory muscles and a decrease in respiratory function.
- Conditions
- Multiple Sclerosis, Breath Tests, MyotonPRO
- Trial name
- NCT07202780
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sanko University
Multiple Sclerosis
Evaluation of Natalizumab for thE Relief of MS Associated FatiGue
This study aims to study the effects of TYSABRI® treatment on fatigue and cognition in patients with relapsing forms of MS.
- Trial name
- ENER-G (NCT00464074)
- Where
- 31 sites in United States, Puerto Rico
- Volunteers
- 89 people
- Sponsor
- Biogen
Fibromyalgia, Chronic Fatigue Syndrome
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03759522
- Testing
- DPA-714 PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis, Fatigue
Effects of Laughter Yoga on Fatigue, Sleep Quality and Psychological Well-Being in Patients With Multiple Sclerosis: A Randomized Controlled Trial
This study is planned to evaluate the effects of laughter yoga applied to patients with multiple sclerosis on fatigue, sleep quality and psychological well-being.
- Conditions
- Multiple Sclerosis, Fatigue, Sleep Quality, Psychological Well-being
- Trial name
- NCT06783413
- Testing
- Intervention group (Laughter Yoga), Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tokat Gaziosmanpasa University
Multiple Sclerosis, Fatigue
Methylphenidate as Treatment Option of Fatigue in Multiple Sclerosis
Fatigue is a common symptom in multiple sclerosis (MS) that is characterized by physical and/or mental exhaustion. Fatigue is difficult to treat and treatment efficacy of available therapy is limited.
- Trial name
- MS (NCT01879202)
- Testing
- Methylphenidate modified release, Maltodextrin
- Where
- Austria
- Volunteers
- 96 people
- Sponsor
- Medical University of Vienna
Multiple Sclerosis, Sarcopenia
Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and…
- Conditions
- Multiple Sclerosis, Sarcopenia, Dynapenia
- Trial name
- MS-Sarcopenia (NCT07842731)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Multiple Sclerosis
Fatigue and Inspiratory Muscles Training in Patients With Multiple Sclerosis
The purpose of this study is to assess the effect of a training of the inspiratory muscles against resistance at home during 10 weeks in multiple sclerosis patients with a severe disability.
- Trial name
- AIRSEP (NCT02726672)
- Testing
- respiratory rehabilitation using Powerbreathe
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Lille Catholic University