Clinical trials: Fatigue in Multiple Sclerosis, open to volunteers
Multiple Sclerosis
Effect of Acetominophen an Gait Fatigue in Multiple Sclerosis
The goal of this observational study is to compare the impact of an antipyretic, acetaminophen to a placebo on gait fatigue in persons with multiple sclerosis (MS).
- Trial name
- NCT07440446
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter College of City University of New York
Hypogammaglobulinemia, Multiple Sclerosis
Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?
The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration <7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and…
- Conditions
- Hypogammaglobulinemia, Multiple Sclerosis, Fatigue
- Trial name
- FatIgG (NCT05357781)
- Testing
- Laboratory test
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fatigue, Walking, Difficulty
Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS
Transcutaneous Electrical Nerve Stimulation (TENS) is a treatment that could potentially reduce walking problems and fatigue in persons with Multiple Sclerosis.
- Conditions
- Fatigue, Walking, Difficulty, Multiple Sclerosis
- Trial name
- NCT06432686
- Testing
- Transcutaneous Electrical Nerve Stimulation, Movement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis
Acupressure in MS Patients
This study aims to evaluate the effects of acupressure therapy on patients with Multiple Sclerosis (MS). MS is a chronic autoimmune disease affecting the central nervous system, characterized by inflammation, demyelination, and…
- Trial name
- APEX-MS (NCT06755463)
- Testing
- Self-acupressure education
- Volunteers
- 82 people
- Sponsor
- Abant Izzet Baysal University
Multiple Sclerosis
Fatigue and Mental Well-Being in MS Patients(Multiple Sclerosis)
This study will be conducted to evaluate the effects of Quran recital on fatigue and mental well-being in patients with multiple sclerosis. Hypotheses: 1. Quran recital reduces fatigue in MS patients. 2.
- Trial name
- MS (NCT07544303)
- Testing
- Quran recital
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Artvin Coruh University
Multiple Sclerosis, Heat Tolerance
Cooling During Inpatient Rehabilitation in Persons With MS
The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Heat Tolerance, Fatigue Symptom
- Trial name
- CoolEx (NCT07852156)
- Testing
- Wearing a cooling vest during intensive, active training sessions, Control
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Klinik Valens
Multiple Sclerosis
Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS).
- Trial name
- CerebellertDCS (NCT07555379)
- Testing
- Bilateral Cerebellar Transcranial Direct Current Stimulation (ctDCS)
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Multiple Sclerosis
Hesperidin RCT in MS
This study is a randomised, double-blind, placebo-controlled trial investigating the effects of Hesperidin supplementation on cognitive function, fatigue, and stress.
- Trial name
- NECTAR-MS (NCT07452562)
- Testing
- Hesperidin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Swansea University
Multiple Sclerosis, Sarcopenia
Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and…
- Conditions
- Multiple Sclerosis, Sarcopenia, Dynapenia
- Trial name
- MS-Sarcopenia (NCT07842731)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Multiple Sclerosis
Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study
The goal of this clinical trial is to learn if a comprehensive rehabilitation programme can improve physical function, reduce fatigue, and raise quality of life in adults aged 18-65 with multiple sclerosis (MS).
- Trial name
- RECONNECT-MS (NCT07666958)
- Testing
- Individual Physiotherapy, Group Movement Awareness, Group Psychotherapy
- Where
- Czechia
- Volunteers
- 45 people
- Sponsor
- Charles University, Czech Republic
Fatigue in Multiple Sclerosis, Multiple Sclerosis
Fatigue in Multiple Sclerosis and Its Relationship to Inflammatory and Neurodegenerative Markers of the Disease
The study is focused on several independent quantifiable biomarkers (sNfL, sGFAP, mitochondrial activity, genetics and fatigue tests) to obtain more detailed information about MS and its progression.
- Conditions
- Fatigue in Multiple Sclerosis, Multiple Sclerosis, Neurofilaments Light Chains, GFAP
- Trial name
- MITOFATIGUE (NCT07025122)
- Where
- Slovakia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Multiple Sclerosis, Relapsing-Remitting, Fatigue
Fatigue Alleviation Through Neuromodulating Therapy in Multiple Sclerosis
The goal of this clinical trial is to learn if repetitive Transcranial Magnetic Stimulation (rTMS) of the left premotor cortex can lessen fatigue in patients with Multiple Sclerosis, and if this is a feasible intervention.
- Trial name
- FANTiMS (NCT06569550)
- Testing
- Real Repetitive Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Progressive Multiple Sclerosis
Study of Circadian Focused Light Therapy in Progressive Multiple Sclerosis
The study is being done to determine if treatment with a novel form of light therapy is tolerated in patients with progressive multiple sclerosis.
- Trial name
- NO-FATIGUE (NCT06261528)
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Sclerosis, Fatigue
Eccentric Exercise and Fatigue in Multiple Sclerosis
The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis (MS).
- Trial name
- NCT06505421
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hunter College of City University of New York
Multiple Sclerosis
Relationship Between Single- and Dual-Task Obstacle Crossing Performance and Fatigue and Disability in Multiple Sclerosis
This cross-sectional observational study aims to investigate the relationship between obstacle crossing performance under single-task and dual-task conditions and the levels of fatigue and disability in individuals with…
- Trial name
- NCT07736482
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Afyonkarahisar Health Sciences University
Multiple Sclerosis
Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy.
Multiple Sclerosis (MS) is a chronic neurological disease impacting 2.8 million individuals globally, with fatigue being its most debilitating symptom, reported by 75% of patients.
- Trial name
- NIBS_MSf (NCT07842302)
- Testing
- TMS, tDCS
- Volunteers
- 80 people
- Sponsor
- Universitat Oberta de Catalunya
Multiple Sclerosis, Multiple Sclerosis Fatigue
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness.
- Trial name
- SOLARIMS (NCT06170970)
- Testing
- Solriamfetol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS)
Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis.
The goal of this clinical trial is to learn if an online wellness program can lower fatigue and improve mood and quality of life in people with progressive multiple sclerosis who are 45 to 70 years old and are experiencing…
- Trial name
- DEW (NCT07831928)
- Testing
- Online wellness course and online exercise platform, Usual Care Group
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Iowa
Multiple Sclerosis
Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity
The study aimed to explore the link between urinary incontinence (UI) severity in patients with multiple sclerosis (PwMS), electromyography (EMG) findings, and other relevant factors.
- Trial name
- NCT07236684
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Artvin Coruh University