Clinical trials: Fatty Acid Metabolism
Sleep, Sleep Deprivation
Sleep Loss and Glucose Metabolism in People With Family History of Type 2 Diabetes.
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism…
- Conditions
- Sleep, Sleep Deprivation, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT00721019
- Testing
- 5-hour bedtime, 8.5-hour bedtimes
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dyslipidemia
Development of a Novel Method to Study in Vivo Fatty Acid Metabolism Using Stable Isotope Labeled Fatty Acids in Humans
Specific Aim 1: To compare the metabolic fate (transport, conversion and oxidation) of labeled 18:0 (13C18:0) and its metabolic product 18:1 (13C18:1) in the fed state after habituation to diets enriched in the corresponding…
- Trial name
- NCT02312492
- Testing
- Oleic Diet, Palmitic Diet, Stearic Diet
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tufts University
Healthy
Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA
The goal of this clinical trial is to learn whether a dietary supplement can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07127445
- Testing
- OEA supplement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nicole Stevens, PhD
Diabetes, Insulin Resistance
Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl
An increase of plasma free fatty acids impairs insulin secretion and insulin sensitivity, thereby playing an important role in causing type 2 diabetes.
- Trial name
- NCT00533559
- Testing
- sodium phenylbutyrate
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Weight Loss, Bone Density
Metabolic Health, Bones and Nuts During Weight Loss in Adults
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group.
- Conditions
- Weight Loss, Bone Density, Obesity and Overweight
- Trial name
- BERN (NCT06949280)
- Testing
- Peanut Snack Experimental, Nut-free Snack
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Inflammation, Insulin Sensitivity
Effects of Dietary Fats on Cardiovascular Health and Insulin Sensitivity in Subjects With Abdominal Obesity
Rationale: It is well established that increased intake of saturated fatty acids (SFA) is associated with incidence of cardiovascular heart disease (CHD).
- Trial name
- NCT01665482
- Testing
- A 2000 kcal test meal, A 2000 kcal test meal which accounts for 7% fat exchange with carbohydrate
- Where
- Malaysia
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Obesity
Circulating Microvesicles Regulating Metabolic Homeostasis in Obesity After Caloric Restriction Programs
The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating…
- Trial name
- TREV (NCT06395246)
- Testing
- Active Comparator: Continuous calorie restriction, eTRE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Cardiovascular Risk Factors
A Study of Different Types of Fatty Acid on Risk Factors for Heart Disease
Experimental elevation of non-esterified fatty acids (NEFA) impairs endothelial function and insulin sensitivity but the impact of NEFA composition is unknown.
- Trial name
- eFAIRE (NCT01351324)
- Testing
- Absence or presence of fish oil
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Reading
Obesity
A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Aged 20-60 Years Old
The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.
- Trial name
- NCT01797042
- Testing
- Dietary Compliance
- Where
- United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Rippe Lifestyle Institute
Ketonemia
Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants
Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
- Trial name
- Opti-MCT (NCT03830268)
- Testing
- No MCT intake with breakfast, no lunch, No MCT intake with lunch, no breakfast, 10g of Betaquik
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Type 2
Effects of Fats on Blood Glucose in People With and Without Type 2 Diabetes Mellitus
People with type 2 diabetes mellitus (earlier known as maturity onset diabetes mellitus) have high blood levels of sugar and fat.
- Trial name
- NCT00308373
- Testing
- Metformin vs Thiazolidinedione (Pioglitazone)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity
Acylated Ghrelin Response to Acute Exercise in Obesity
Ghrelin is a GH-secretagogue gastrointestinal hormone that regulates feeding behavior by interacting directly with hypothalamic centers in concert with other negative and permissive neuromodulators.
- Trial name
- aeroghre (NCT00486161)
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Insulin Sensitivity, Lipid Metabolism
Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety
The objective of this study is to assess whether intake of baked and then chilled potatoes over a 24-h period, compared to intake of isocaloric, carbohydrate (CHO)-matched foods low in fiber and resistant starch (RS), will…
- Conditions
- Insulin Sensitivity, Lipid Metabolism, Resistant Starch, Potato
- Trial name
- NCT03689738
- Testing
- Potato (Resistant Starch), CHO-matched (Low-fiber, RS-free)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Dyslipidemias
Fatty Acid Biomarkers of Carbohydrate Intake
The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
- Trial name
- CARBIO (NCT03295448)
- Testing
- Low carbohydrate diet, High carbohydrate, high sugar diet, High carbohydrate, low sugar diet
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity
Effects of n-3 Intake on Lipid Profile, Biochemical and Inflammatory Markers in Subjects With Obesity
Obesity is a chronic disease characterized by the excessive accumulation of adipose tissue that is harmful to health. Dietary habits modification through a caloric restriction, macronutrient distribution including linoleic and…
- Trial name
- NCT04901052
- Testing
- n-3 supplementation group
- Where
- 2 sites in Mexico
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Klinefelter Syndrome
Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome
This study will learn more about how the body uses energy. Usually, the body uses sugars as energy first and then fats are used when the sugar stores are gone. Some people have trouble using fats as energy.
- Trial name
- NCT05498090
- Testing
- Fenofibrate 145 mg
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vitamin/Nutritional Deficiency, Neurobehavioral Manifestations
Walnuts, Long-Chain Polyunsaturated Fatty Acids and Adolescent Brain Development
Background: Adolescence is an important period for brain development as a result of increased synaptic plasticity. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients for brain development and protection…
- Trial name
- WALNUTs (NCT02590848)
- Testing
- Walnut intake
- Where
- Spain
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Healthy
Juice Plus+OMEGA Study
In this randomized, controlled clinical study firstly the bioavailability of fatty acids and micronutrients of JP+® Omega Blend will be analysed.
- Trial name
- NCT03348553
- Testing
- control group, Omega2, Omega4
- Where
- 2 sites in Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Green Beat
Hyperlipemia
Effect of Consumption of Bagel Without Palm Oil on Postprandial Lipidemia
Postprandial lipemia produced by fat intake is a major risk factor for the development of cardiovascular diseases (CVD), the most important cause of disease and death in the Western world.
- Trial name
- PALMFREE (NCT03950752)
- Testing
- Optimized Bagel, Conventional Bagel
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Satiety Hormones, Short-chain Fatty Acids
The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the impact of short-chain fatty acids (SCFA) on the gut hormone release after administration in the small intestine or colon in healthy participants.
- Conditions
- Satiety Hormones, Short-chain Fatty Acids, Satiety and Appetite, Intestinal Absorption
- Trial name
- Histine (NCT06686888)
- Testing
- SCFA, microcristalline cellulose
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KU Leuven