Clinical trials: Fatty Acid Oxidation
Obesity
Obesity, Physical Inactivity or Dietary Fat ?
Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary…
- Trial name
- NCT00434265
- Testing
- Physical training
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Strasbourg, France
Mitochondrial Myopathies, Fatty Acid Oxidation Defects
Resveratrol Supplementation in Patients With Mitochondrial Myopathies and Skeletal Muscle Fatty Acid Oxidation Disorders
The purpose of this study is to investigate the potential beneficial effects of a daily supplement of Resveratrol (1000mg/day) on physical ability and on muscle metabolism in patients with verified mitochondrial myopathy and…
- Trial name
- NCT03728777
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD), Carnitine Palmitoyltransferase (CPT II) Deficiency
A Study of UX007 (Triheptanoin) in Participants With Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD)
The primary objective of the study was to evaluate the impact of UX007 on acute clinical pathophysiology associated with LC-FAOD following 24 weeks of treatment.
- Conditions
- Long-chain Fatty Acid Oxidation Disorders (LC-FAOD), Carnitine Palmitoyltransferase (CPT II) Deficiency, Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency, Longchain 3-hydroxy-acyl-CoA Dehydrogenase (LCHAD) Deficiency
- Trial name
- NCT01886378
- Testing
- UX007
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 29 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency
High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders
The study also determines if eating a diet higher in protein alters body composition, energy balance and metabolic control among patients with a long-chain fatty acid oxidation disorder.
- Conditions
- Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency, Carnitine Palmitoyltransferase 2 Deficiency, Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
- Trial name
- NCT01494051
- Testing
- Diet counseling
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Metastatic Renal Cell Carcinoma
Measuring Treatment Response in Metastatic Renal Cell Cancer Using FPIA PET/CT
Renal cell carcinoma (RCC) is the most prevalent and lethal malignancy of the kidney. At the time of diagnosis, as many as a fifth of patients have metastatic disease (mRCC).
- Trial name
- NCT04802824
- Testing
- PET/CT
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Cancer-related Fatigue, Breast Cancer
Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors
This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF).
- Conditions
- Cancer-related Fatigue, Breast Cancer, Prostate Cancer
- Trial name
- NCT07001241
- Testing
- Telehealth Exercise Program
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Colorado, Denver
Metabolic Syndrome X, Insulin Resistance
Physical Inactivity and Insulin Resistance in Skeletal Muscle.
The purpose of this study is to determine how a decline in physical activity acutely leads to a decrease in insulin sensitivity in skeletal muscle.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Hypertension, Hypercholesterolemia
- Trial name
- NCT00536211
- Testing
- Exercise, Metformin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Atrial Fibrillation Paroxysmal
Efficacy of Personalized Exercise Program and Trimetazidine in Rehabilitation of Patients After RFA of AF
Atrial fibrillation (AF) is one of the most common forms of heart rhythm disorder in patients with cardiovascular diseases. The choice of treatment for AF is a complex problem, depending on the form (paroxysmal, persistent…
- Trial name
- NCT04511520
- Testing
- Physical training program, Trimetazidine
- Volunteers
- 72 people
- Sponsor
- National Research Center for Preventive Medicine
VLCAD Deficiency, Fatty Acid Oxidation Defects
Acute Nutritional Ketosis in VLCAD Deficiency
To test if a ketone-ester based drink can boost muscle mitochondrial function in vivo in patients with VLCADD in order to establish a rational basis for therapeutic use in this disorder.
- Trial name
- NCT03531554
- Testing
- ketone ester drink, exercise, muscle biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 5 people
- Sponsor
- University Medical Center Groningen
Non-Alcoholic Fatty Liver Disease
MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH)
One-third of the world's population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD), that is a disease with an accumulation of fat in the liver.
- Trial name
- MRI-Detect (NCT04227782)
- Testing
- Magnetic Resonance Imaging, Stable Isotope Study
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Long-chain Fatty Acid Transport Deficiency
Triheptanoin Treatment Trial for Patients With Long-chain Fatty Acid Beta-oxidation Defects
The purpose of this study is to determine if administration Triheptanoin is an effective treatment for defects of the long-chain fatty acid beta-oxidation in young adults or adults.
- Trial name
- NCT02201368
- Testing
- Triheptanoin (SpezialölÒ 107®), MCT (Medium-Chain Triglycerides)
- Where
- Spain
- Sponsor
- Maria Luz Couce Pico
Diabetes Mellitus, Type 2, Metabolic Cardiomyopathy
Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
The number of people with diabetes is rising. One of the major causes of premature death in diabetes is heart failure (HF). This is when the heart cannot pump blood effectively, and this may be related to abnormalities in energy…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Cardiomyopathy, Metabolic Disturbance, Fatty Acid Oxidation Disorder
- Trial name
- CardioMET (NCT04009642)
- Testing
- Surely observational based on disease state
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Leicester
Inborn Errors of Metabolism
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids
Usual dietary therapies of mitochondrial fatty acid oxidation disorders (FAO) are based on 3 strategies: limitation of lipid intake in the diet; supplementation of the diet with medium-chain triglycerides (MCT) for patients…
- Trial name
- NCT00328159
- Testing
- Oil special 107 and MYGLIOL 810
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trifunctional Protein Deficiency
Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
Several hormones involved in body weight regulation increase the subject's ability to burn fat for energy. The purpose of this study is to investigate how burning fat for energy may affect those hormones and body weight in…
- Trial name
- NCT00654004
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Metabolic Health
ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks
The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.
- Trial name
- COMET (NCT05820490)
- Testing
- Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity
This study is open to adults between 18 and 65 years of age who have obesity. People can join the study if they have a body mass index (BMI) between 30 and 45 km/m².
- Trial name
- NCT06745284
- Testing
- Survodutide, Semaglutide
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Boehringer Ingelheim
Glioma
Measuring Fatty Acid Oxidation in Gliomas Using 18F-FPIA PET/MRI
Glioma is the most common primary malignant brain tumour in adults and has an extremely poor prognosis. The aim of this study is to quantify the degree of early step fatty acid oxidation in gliomas as imaged by 18F-FPIA PET/MRI…
- Trial name
- NCT04097535
- Testing
- PET/MRI
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Imperial College London
Urea Cycle Disorders, Organic Acidemias
At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism
The goal of this observational study is to learn if people with certain ammonia metabolism disorders will measure their ammonia levels at home.
- Conditions
- Urea Cycle Disorders, Organic Acidemias, Fatty Acid Oxidation Disorder, Ammonia; Metabolic Disorder
- Trial name
- NCT06953505
- Testing
- Ammonia Study Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sequitur Health Corp.
Diabetes
A Comparison of Measurements of Ketone Body Flux Versus Ketone Body Concentration as a Pharmacodynamic Marker of Hepatic Fatty Acid Oxidation (0000-110)
This study will compare two approaches to the measurement of fatty acid oxidation (ketone body flux and ketone body concentration) and determine which method demonstrates superior sensitivity and variability in the detection of…
- Trial name
- NCT00860392
- Testing
- Stable isotope tracer (13-C(4)-BHB)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2, Overweight
Mitochondrial Dysfunction in Type 2 Diabetes Mellitus and Capacity for Fat Oxidation During Exercise
The purpose of this study is to compare the effects of an 8-week aerobic training program upon fat oxidation in vivo and markers of skeletal muscle mitochondrial content and oxidative capacity in sedentary obese subjects with and…
- Trial name
- NCT00382473
- Testing
- Aerobic exercise program - 8 weeks
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh