Clinical trials: Fear Conditioning
Anxiety Disorders
Neurobiology of Generalized Fear-Conditioning & Avoidance in Anxiety Disorders
Anxiety disorders are among the most prevalent, costly, and disabling mental illnesses. One central, yet largely understudied, abnormality in anxiety disorders is the heightened tendency to display fear and avoidance in reaction…
- Trial name
- NCT03033056
- Testing
- Test of fear conditioning
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stress Disorders, Post-Traumatic
Cerebral GABA and Fear Conditioning in PTSD
Posttraumatic stress disorder (PTSD) is a common and debilitating neuropsychiatric disorder in which an acute fear response to a traumatic event does not abate.
- Trial name
- NCT01800383
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Isabelle Rosso
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fear, Stress
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
Background: Researchers want to learn if people with alcohol dependence have more difficulty learning to feel calm, or learn to fear things more easily.
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02438969
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Post Traumatic Stress Syndrome
The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.
PROJECT SUMMARY: PTSD is a debilitating psychiatric condition precipitated by exposure to extreme, or life threatening, trauma with an estimated lifetime prevalence between 8% and 9% in U.S. adults.
- Trial name
- DCS (NCT01733030)
- Testing
- Seromycin
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Fear of Spiders
The Neural Mechanisms of Imaginal Extinction
Imaginal exposure is a widely used and effective psychological treatment technique in which patients are exposed to fearful stimuli and situations using mental imagery.
- Trial name
- NCT05168592
- Testing
- Threat conditioning, Imaginal extinction
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Fear Conditioning
Cannabinoid Augmentation of Fear Response in Humans
The purpose of this double blind, randomized, controlled, proof-of-concept study is to test the effects of cannabinoid receptor augmentation on the facilitation of fear conditioning.
- Trial name
- NCT01665573
- Testing
- PF-04457845
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
Fear Anxiety, PTSD
Neuroimaging Memories of Fear and Safety in the Human Brain
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli.
- Trial name
- NCT04975009
- Testing
- Fear conditioning
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Anxiety Disorders
Spatial Context and Fear Learning
Background: Fear is a normal response to a threat. Learning fear can be helpful sometimes. For people with anxiety disorders, fear can be long-lasting and too intense.
- Trial name
- NCT02423044
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fear Conditioning
Influence of Escitalopram on Fear Conditioning
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking an antidepressant medication. This medication is called Lexapro (Escitalopram).
- Trial name
- NCT01398514
- Testing
- Escitalopram
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety and Fear
Cannabidiol Effects on Learning and Anxiety
To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety.
- Trial name
- NCT05283382
- Testing
- Cannabidiol Oral Product
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Anxiety and Fear, PTSD
K08 VR Fear Conditioning
The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment.
- Conditions
- Anxiety and Fear, PTSD, Veteran
- Trial name
- NCT07216222
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Functional Neuroanatomy of Emotion Perception, Recognition, Learning, and Memory
This study uses magnetic resonance imaging (MRI) to explore the areas of the brain involved in different types of mental processes, in particular, the brain regions involved in perception, recognition, learning, and memory.
- Trial name
- NCT00458432
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorder
Fear Conditioning Using Computer-Generated Virtual Reality
The purpose of this study is to use a computer-generated virtual reality environment to study fear conditioning. Fear conditioning is used to explore the causes and persistence of anxiety and anxiety disorders.
- Trial name
- NCT00025844
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorder
Effects of Verbal Instructions on Fear Extinction and Extinction Retrieval
The goal of this study is to examine if verbal instructions can improve fear extinction learning and extinction retrieval in patients with anxiety disorders (AD) and healthy controls.
- Trial name
- NCT05718271
- Testing
- Explicit instructions before extinction, Explicit instructions after extinction
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Anorexia, Generalized Anxiety
Overgeneralization of Conditioned Fear as a Pathogenic Marker of Anorexia Nervosa
Anorexia nervosa is a chronic mental health condition characterized by maladaptive food consumption (i.e., hypophagia) and distorted body image.
- Trial name
- NCT02148042
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Fear, Stress
Traits Associated With Early Life Stress Among Treatment-Seeking Alcoholics
Background: Researchers want to see if people with alcohol dependence have more trouble learning to feel calm, or learn to fear things more easily, than non-alcoholics and to study how early life stress (ELS) affects these…
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02181608
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Pediatric Anxiety Disorders
Fear Conditioning, Extinction and Its Recall in Anxious Youth
The proposed research aims to isolate brain-based information-processing mechanisms implicated in perturbed fear learning and extinction characteristic of pediatric anxiety.
- Trial name
- FCPA (NCT02631785)
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Haifa