Clinical trials: Fecal Microbiota Therapy (FMT)
Ulcerative Colitis
Fecal Microbiota Transplantation in Patients With Ulcerative Colitis
The purpose of this study is to find out whether a single fecal microbiota transplantation is an effective and safe treatment as an adjunct to standard therapy in patients with ulcerative colitis.
- Trial name
- NCT01961492
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Sponsor
- Turku University Hospital
Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
FMT Plus SHR-1701 With Nab-Paclitaxel/Gemcitabine as First-Line Treatment for Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma
This is a prospective, single-center, randomized, open-label, two-arm Phase II clinical trial design to evaluate the feasibility, safety and preliminary efficacy of combining fecal Fecal Microbiota Transplantation （FMT） Combined…
- Trial name
- NCT07845565
- Testing
- FMT+Chemotherapy+Immunotherapy, Chemotherapy+Immunotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Metastatic Colorectal Adenocarcinoma, Metastatic Small Intestinal Adenocarcinoma
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders
This phase II trial studies the effect of fecal microbiota transplant and re-introduction of anti-PD-1 therapy (pembrolizumab or nivolumab) in treating anti-PD-1 non-responders with colorectal cancer that has spread to other…
- Conditions
- Metastatic Colorectal Adenocarcinoma, Metastatic Small Intestinal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Small Intestinal Adenocarcinoma AJCC v8
- Trial name
- NCT04729322
- Testing
- Biopsy, Fecal Microbiota Transplantation, Fecal Microbiota Transplantation Capsule
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Ulcerative Colitis (UC)
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon and rectum, characterized by mucosal inflammation and symptomslike diarrhea, abdominal pain, and rectal bleeding.
- Trial name
- ALTER-UC (NCT06895252)
- Testing
- Anti inflammatory diet, Fecal Microbial Transplantation
- Where
- 6 sites in India
- Volunteers
- 220 people
- Sponsor
- All India Institute of Medical Sciences
Depression, Treatment Resistant Depression
The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder
The primary goals of this proof of concept clinical trial are to determine the effectiveness, safety and tolerability of oral FMT in adults with Treatment Resistant Depression (TRD).
- Trial name
- NCT04805879
- Testing
- FMT oral Capsules
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
HIV-1-infection
Safety of FMT Using Oral Encapsulated PRIM-DJ2727 in HIV
The purpose of this study is to determine whether oral fecal microbiota transplantation (FMT) is safe for people with human immunodeficiency virus (HIV) infection.
- Trial name
- NCT03329560
- Testing
- Oral fecal microbiota transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hepatocellular Carcinoma, Hepatocellular Cancer
Patients With Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide and is frequently diagnosed at an advanced stage, resulting in limited therapeutic options.
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Liver Diseases, Liver Cancer
- Trial name
- FORCE (NCT07690683)
- Testing
- Fecal microbiota transplantation performed via colonoscopy.
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Graft-Versus-Host Disease (Gvhd) Grade, Hematopoietic Cell Transplantation
FMT In High-Risk Acute GVHD After ALLO HCT
The purpose of this study is to evaluate the effectiveness of Fecal Microbiota Transplant (FMT) treatment in high-risk acute graft-versus-host disease (GVHD). This research study involves an experimental intervention called FMT.
- Conditions
- Acute Graft-Versus-Host Disease (Gvhd) Grade, Hematopoietic Cell Transplantation, Fecal Microbiota Transplant
- Trial name
- NCT04139577
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Clostridium Difficile Infection, Infection
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS)
This is a prospective, multicenter, open-label Phase 3 study of a microbiota suspension of intestinal microbes. Patients who have had at least one recurrence of CDI after a primary episode and have completed at least one round of…
- Conditions
- Clostridium Difficile Infection, Infection, Communicable Diseases
- Trial name
- CD3-OLS (NCT03931941)
- Testing
- RBX2660
- Where
- 51 sites in United States, Canada
- Volunteers
- 793 people
- Sponsor
- Rebiotix Inc.
Steroid-Resistant Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome
Study on the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Steroid - Dependent /Steroid-resistant Nephrotic Syndrome in Children
The objective of this clinical trial was to understand whether FMT is effective in treating steroid-dependent/steroid-resistant nephrotic syndrome in children. It will also learn about the safety of FMT.
- Trial name
- NCT07003438
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 120 people
- Sponsor
- Zhang Ting
Fecal Microbiota Transplantation
Clinical Safety and Efficacy of Fecal Microbiota Transplantation (FMT) in the Treatment of Alzheimer's Disease
To investigate the clinical safety and efficacy of FMT in AD patients, as well as the changes in the gut microbiota of AD patients before and after FMT.
- Trial name
- NCT06920212
- Testing
- FMT capsule
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 10th People's Hospital
Clostridium Difficile Infection
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection
This study will evaluate efficacy and safety information about RBX2660 for the treatment of recurrent Clostridium difficile infection (CDI), and will compare the efficacy of one treatment with RBX2660 versus antibiotic-treated…
- Trial name
- NCT02589847
- Testing
- RBX2660, Standard of Care Antibiotics
- Where
- 30 sites in United States, Canada
- Volunteers
- 272 people
- Sponsor
- Rebiotix Inc.
C. Difficile
Fecal Microbiota Transplantation to Treat Recurrent C. Difficile Associated Diarrhea Via Retention Enema or Oral Route
The objective of the study is to investigate the safety of a frozen or lyophilized inoculum administered, respectively, by retention enema or capsules in patients with recurrent C. difficile associated diarrhea (RCDAD).
- Trial name
- NCT02449174
- Testing
- Frozen Microbiota, Lyophilized Microbiota
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The University of Texas Health Science Center, Houston
Autism Spectrum Disorder, Gastro-Intestinal Disorder
MTT for Children With ASD Who Have Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating children with Autism Spectrum Disorder (ASD) and gastrointestinal problems (primarily constipation and/or diarrhea).
- Conditions
- Autism Spectrum Disorder, Gastro-Intestinal Disorder, Constipation, Diarrhea
- Trial name
- NCT04182633
- Testing
- vancomycin, Miralax, intestinal microbiota
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Arizona State University
Autism Spectrum Disorder, Autism
Vancomycin and Fecal Microbiota Transplant in a Single Patient With Autism Spectrum Disorder
Single patient with ASD will be treated with Vancomycin followed by FMT.
- Trial name
- NCT04878718
- Testing
- Fecal Microbiota Transplant; Vancomycin
- Where
- United States
- Sponsor
- ProgenaBiome
Clostridioides Difficile Infection
Clostridioides Difficile: Understanding Responses and Treatment Effects
The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery.
- Trial name
- CURE-CDI (NCT07374094)
- Testing
- Antibiotic treatment, Fecal microbiota transplantation (FMT)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Irritable Bowel Syndrome
Faecal Microbiota Transplantation (FMT) in Patients With IBSmechanism(s) of Action
Two hundrad patients are randomized to either 90 g transplant, 90 g transplant twice with 1week interval into the distal small intestine via working channel of a gastroscope, or to 90 g transplant into the coecum of the colon via…
- Trial name
- NCT04236843
- Testing
- Feces
- Where
- Norway
- Volunteers
- 186 people
- Sponsor
- Helse Fonna
Constipation - Functional, Fecal Microbiota Transplantation (FMT)
The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of Functional Constipation：a Pilot Study
Chronic constipation is a common gastrointestinal disease with a global prevalence of about 15%, significantly affecting daily life and quality of life.
- Conditions
- Constipation - Functional, Fecal Microbiota Transplantation (FMT), Chronic Constipation
- Trial name
- NCT07387952
- Testing
- FMT
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Peking Union Medical College Hospital
Frail Elderly, Clostridioides Difficile
Clostridioides Difficile and Frailty
CDI is a major cause of antibiotics-associated diarrhoea. More than half of the patients affected are 70 years or older and frail. Mortality among older patients with CDI is high.
- Conditions
- Frail Elderly, Clostridioides Difficile, Geriatric Assessment, Faecal Microbiota Transplantation
- Trial name
- CLODIFRAIL (NCT05447533)
- Testing
- Comprehensive geriatric assessment (CGA), Continued geriatric care, Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Clostridium Difficile Infection
Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)
The purpose of this study is to determine whether Fecal Microbiota Therapy (FMT) is effective vs. placebo in the prevention of C. difficile infection recurrence.
- Trial name
- MATCH (NCT03005379)
- Testing
- Fecal Microbiota Therapy (FMT)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- VA Office of Research and Development