Clinical trials: Fecal Microbiota Therapy (FMT)
Hepatocellular Carcinoma, Hepatocellular Cancer
Patients With Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide and is frequently diagnosed at an advanced stage, resulting in limited therapeutic options.
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Liver Diseases, Liver Cancer
- Trial name
- FORCE (NCT07690683)
- Testing
- Fecal microbiota transplantation performed via colonoscopy.
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intestinal Graft Versus Host Disease
Fecal Microbiota Transplant and Dietary Fiber Supplementation for the Treatment of Gut Graft Versus Host Disease
This phase I trial studies how well fecal microbiota transplant and dietary fiber supplementation work in treating patients with gut graft versus host disease.
- Trial name
- NCT05067595
- Testing
- Colonoscopy, Fecal Microbiota Transplantation, Nutritional Supplementation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV Infections
Fecal Microbiota Transplantation as a Therapeutic Strategy for Patients Infected With HIV
Patients eligible for the study will be selected on Fridays during the HIV consultation at the Infectious Diseases Department. Patients that meet the inclusion and exclusion criteria, will be randomized and assigned in two groups…
- Trial name
- NCT04165200
- Testing
- Blood and feces samples
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Ulcerative Colitis
Clinical Study on the Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis With Depression
This is a single-center trial, randomized, single-blind, placebo-controlled clinical intervention study which intends to explore the safety and effectiveness of FMT capsule for the treatment of ulcerative colitis with depression.
- Trial name
- NCT05030064
- Testing
- Intestinal flora capsule
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Third Military Medical University
Hepatic Encephalopathy
Microbiota, Sarcopenia, and Hepatic Encephalopathy Change in Cirrhotic Patients Before and After Rehabilitation
Through this plan, it will provide many benefits to patients with liver cirrhosis complicated with sarcopenia and/or hepatic encephalopathy, their family members, and the government in Taiwan: 1.
- Trial name
- NCT06040814
- Testing
- Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Ulcerative Colitis
Fecal Transplantation in Ulcerative Colitis
Adult individuals with ulcerative colitis in remission are given a single fecal microbiota transplantation (FMT) in colonoscopy.
- Trial name
- FMT-CU (NCT03561532)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- 2 sites in Finland
- Volunteers
- 48 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Active Ulcerative Colitis (UC)
Study to Evaluate the Fecal Microbiota Transplantation (FMT) in the Treatment of Ulcerative Colitis
The study is to evaluate the safety, feasibility, and preliminary efficacy of frozen FMT delivery via retention enema compared to lyophilized powder given in oral capsules as induction FMT in subjects with active UC.
- Trial name
- NCT05786404
- Testing
- PRIM-DJ2727 - FROZEN, PRIM-DJ2727 - CAPSULES
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Recurrent Clostridium Difficile Infection
Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection
The primary goal is to study participants with recurrent C. difficile infection (CDI) treated with lyophilized fecal microbiota transplantation (FMT). The safety, clinical response and relapse rate in patients will be assessed.
- Trial name
- NCT03834038
- Testing
- Lyophilized Fecal Microbiota Transplantation
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- Vancouver Island Health Authority
Irritable Bowel Syndrome
Fecal Microbiota Transplantation for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome
The objectives of this study are (1) to determine the efficacy of fecal microbiota transplantation (FMT), given as oral capsules, compared with placebo for the treatment of refractory diarrhea-predominant irritable bowel syndrome…
- Trial name
- NCT02328547
- Testing
- Fecal microbiota transplantation capsules
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Montefiore Medical Center
Autism, Autism Spectrum Disorder
Familial Fecal Microbiota Transplant for the Treatment of Subjects With Autism Spectrum Disorders
This is an open-label clinical trial to evaluate the benefits of familial fecal microbiota transplant following a 6-week treatment with Vancomycin in adult subjects with ASD for treatment of social deficits and language delays.
- Trial name
- NCT04630847
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- ProgenaBiome
PCOS (Polycystic Ovary Syndrome)
Fecal Microbiota Transplantation for Obese Women With Polyendocrine Metabolic Ovarian Syndrome
This prospective, two-stage clinical trial aims to evaluate the safety, preliminary efficacy, and reproductive outcomes of oral Fecal Microbiota Transplantation (FMT) freeze-dried capsules in overweight and obese patients with…
- Trial name
- FMT-PMOS (NCT07746635)
- Testing
- oral Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Shanghai Changzheng Hospital
Delirium
Fecal Microbiota Transplantation for the Treatment of ICU Delirium
Delirium in the intensive care unit (ICU) is a prevalent and serious neurological complication among critically ill patients, with large multicenter studies reporting an incidence of 30% to 80%, particularly in those requiring…
- Trial name
- FMTID (NCT07348471)
- Testing
- Intestinal microbiota suspension
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Clostridium Difficile Infections
Virus as Treatment of C. Difficile Infection (VISION)
Fecal Virome Transplantation (FVT) has in small studies shown benefit in the treatment of recurrent C. difficile infection. In the VISION study we will treat patients with recurrent C.
- Trial name
- VISION (NCT06398379)
- Testing
- Fecal Virome Transplantation, Fecal microbiota Transplantation
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Irritable Bowel Syndrome
Gut Microbiota Reconstruction in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea
The purpose of this study is to evaluate the efficacy as well as safety of rifaximin combined fecal microbiota transplantation(Gut microbiota reconstruction) in the treatment of IBS-D.
- Trial name
- NCT02651740
- Testing
- Rifaximin, Fecal microbiota transplantation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
Inflammatory Bowel Diseases
Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide .
- Trial name
- NCT06591013
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Intestinal GVHD
Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD
Therapy of severe intestinal graft-versus-host disease (GVHD) despite the introduction of novel target agents is associated with worse outcome compared to the other forms.
- Trial name
- JAK-FMT (NCT04269850)
- Testing
- allogeneic fecal microbiota, Ruxolitinib, Methylprednisone
- Where
- Russia
- Volunteers
- 2 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Fecal Microbiota Transplantation
The Safety and Efficacy of Fecal Microbiota Transplantation in the Treatment of Digestive Diseases and Non-digestive System Diseases Associated With Gastrointestinal Symptoms in the Gastrointestinal Tract.
The exploration of the safety and efficacy of fecal microbiota transplantation in the treatment of non-digestive system diseases associated with gastrointestinal symptoms in the gastrointestinal tract, while also investigating…
- Trial name
- NCT06208930
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai 10th People's Hospital
Sclerosing Cholangitis
Fecal Microbiota Transplantation for the Treatment of Primary Sclerosing Cholangitis.
This is an open-label single-arm pilot study to measure the safety, microbiological and clinical impacts of Fecal Microbiota Transplantation (FMT) in patients with Primary Sclerosing Cholangitis (PSC).
- Trial name
- NCT02424175
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Clostridium Difficile Infection
A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile Infection
This study is a two-arm, interventional, prospective, open-label, multi-center clinical trial with randomized and non-randomized study groups to evaluate the safety and effectiveness of faecal microbiota transplantation (FMT) for…
- Trial name
- FMTREAT (NCT03053505)
- Testing
- faecal human microbiota transplant (FMT), Vancomycin or Fidaxomicin
- Where
- 3 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Sejtterapia Kozpont Kft.
Chronic Intestinal Pseudo Obstruction
Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstruction
Chronic intestinal pseudo obstruction(CIPO) is a serious motility disorder with life-threatening condition, and it is often related with bacterial overgrowth.
- Trial name
- NCT02731183
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Jinling Hospital, China