Clinical trials: Female Genital Disease
Subfertility
DHEA Versus Placebo in Women With Poor Ovarian Response
440 women with expected poor ovarian response undergoing IVF/ICSI (intracytoplasmic sperm injection) will be randomly divided into 2 groups using computer generated random numbers .
- Trial name
- DHEA (NCT02561793)
- Testing
- DHEA
- Where
- 2 sites in Egypt
- Volunteers
- 440 people
- Sponsor
- Cairo University
Endometrial Cancer, Perioperative Complication
Iron Prehabilitation in Endometrial Cancer
Endometrial cancer patients often have iron deficiency anemia before surgery, which can be effectively treated with oral iron supplementation.
- Conditions
- Endometrial Cancer, Perioperative Complication, Prehabilitation
- Trial name
- IROGYN (NCT06049693)
- Testing
- Ferrous Gluconate 300 MG
- Where
- Greece
- Volunteers
- 156 people
- Sponsor
- National and Kapodistrian University of Athens
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay and Comparison With the HR HC2® Test Using LBC ThinPrep® Specimens
To assess and compare the performance of the HR HPV HC2® test (Qiagen/Digene) and the APTIMA® HPV Assay (Hologic) using LBC Specimens (ThinPrep® Pap Test) for the detection of HPV infection and high-grade CIN lesions in a…
- Trial name
- NCT02634190
- Testing
- Thinprep® LBC, APTIMA® HPV Assay, HR HC2® HPV DNA
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hologic Deutschland GmbH
Sexual Dysfunction
Female Sexual Function and Socioeconomic Status
In an urban gynecology practice serving patients with publicly and privately funded insurance, female sexual dysfunction was associated with low income, depression, urinary incontinence, and sexual inactivity.
- Trial name
- NCT02355860
- Testing
- assessment
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Brett Worly, MD
Infections, Papillomavirus, Cervical Cancer
Study on the Prevalence of Human Papillomavirus Types in Women >= 15 Years of Age in the Kingdom of Saudi Arabia
This study aims to determine the prevalence of human papillomavirus (HPV) and to assess the HPV type distribution among women >= 15 years of age, attending routine gynaecological examination in the Kingdom of Saudi Arabia.
- Trial name
- NCT01213459
- Testing
- Cervical samples, Data collection
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 420 people
- Sponsor
- GlaxoSmithKline
Cervical Carcinoma
Prognostic Value of Protein IMP3 Expression in Cervical Cancer
The results of recent research on cervical cancer and its precancerous lesions have linked the expression of IMP3 protein to cervical dysplasia and the possibility of severe cervical dysplasia (CIN III) progressing to squamous…
- Trial name
- NCT05151159
- Testing
- immunohistochemical analysis with murine monoclonal antihuman antibodies IMP3
- Volunteers
- 80 people
- Sponsor
- University of Mostar
Hyperandrogenism, Polycystic Ovary Syndrome
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CBS010 (NCT04723862)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bacterial Vaginosis
Effect of Different Courses of Lactobacilli Treatment on Bacterial Vaginosis and Pregnancy Outcomes
The purpose of this study is to examine the effect of lactobacillus preparation on Bacterial vaginosis (BV) in low-risk pregnant women and to evaluate the value of double courses for the patients with durative positive result.
- Trial name
- BV (NCT01421615)
- Testing
- Vaginal capsules of lactobacilli
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Ovarian Cancer
Study of the Isotopic Distribution of Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Ovarian Origin
The treatment of advanced ovarian cancer is based on the combination of chemotherapy based on platinum salt and surgery whose quality is the major prognostic factor.
- Trial name
- ISOTOVE (NCT02667925)
- Testing
- Intraperitoneal cisplatin with nanocis
- Where
- France
- Sponsor
- Centre Jean Perrin
Cervical Cancer
Doxorubicin Alone Versus Atezolizumab Alone Versus Doxorubicin and Atezolizumab in Recurrent Cervical Cancer
This is an open-label, multicenter, randomized phase II trial to evaluate the safety and efficacy of atezolizumab in patients with recurrent cervical cancer in second line therapy.
- Trial name
- NCT03340376
- Testing
- Atezolizumab, Doxorubicin
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Female Infertility
Effect of Growth Hormone on Uterine Receptivity in Women With RIF in an Oocyte Donation Program
105 infertile women are enrolled in the randomized controlled trial: 70 women with a history of RIF with donated oocytes and 35 infertile women undergoing the first oocyte donation attempt.
- Trial name
- NCT03237117
- Testing
- Growth Hormone (GH)
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Competence Centre on Health Technologies
Cervical Incompetence
Cervical Occlusion Double-level Stitch Application
Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes…
- Trial name
- COSA (NCT05268640)
- Testing
- Double-level cervical cerclage, Single-level cervical cerclage
- Where
- 7 sites in Poland
- Volunteers
- 81 people
- Sponsor
- Centre of Postgraduate Medical Education
Myoma;Uterus, Vitamin D Deficiency
Vitamin D Levels And Myoma Uteri
Women with at least one uterine leiomyoma and polycystic ovary syndrome over 10 mm and women with normal ultrasonographic findings were included in the study.
- Conditions
- Myoma;Uterus, Vitamin D Deficiency, Polycystic Ovary
- Trial name
- NCT03871868
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Melanoma, Non-small Cell Lung Cancer
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy…
- Conditions
- Melanoma, Non-small Cell Lung Cancer, Breast Cancer, Gastric Cancer
- Trial name
- NCT03329950
- Testing
- CDX-1140, CDX-301, pembrolizumab
- Where
- 11 sites in United States
- Volunteers
- 132 people
- Sponsor
- Celldex Therapeutics
Vaginal Prolapse, Uterine Prolapse
Efficacy Study of Vaginal Mesh for Anterior Prolapse
The primary aim of this double-blind, randomized clinical trial (RCT) is to test the hypothesis that the addition of a standardized technique of interpositional synthetic polypropylene mesh placement improves the one-year outcome…
- Conditions
- Vaginal Prolapse, Uterine Prolapse, Cystocele, Pelvic Organ Prolapse
- Trial name
- VAMP-A (NCT00557882)
- Testing
- synthetic polypropylene mesh
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Medstar Health Research Institute
Prolapse, Vaginal
Women's Knowledge and Attitudes to Use of Mesh in Gynaecological Surgery
This is a questionnaire study that is being performed to ascertain the knowledge and attitudes of women towards use of mesh in gynaecological surgery.
- Trial name
- NCT03527082
- Testing
- Questionnaire
- Volunteers
- 150 people
- Sponsor
- Epsom and St Helier University Hospitals NHS Trust
Ovarian Neoplasms, Peritoneal Neoplasms
Tolerance, Safety, Efficacy, and Pharmacokinetics of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Using Paclitaxel for Platinum-resistant Recurrent Ovarian Cancer
The purpose of this study is to evaluate the tolerance, safety, efficacy, and pharmacokinetics of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with paclitaxel in patients with platinum-resistant recurrent ovarian…
- Trial name
- NCT07273396
- Testing
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC) using paclitaxel
- Volunteers
- 53 people
- Sponsor
- Seoul National University Hospital
Pregnancy, Sexually Transmitted Infections
e-SiHLE: An Internet Pregnancy Prevention for Older Teenage Girls
The purpose of this study is to evaluate the efficacy of an online pregnancy prevention intervention that was adapted from the evidence based small group intervention SiHLE.
- Trial name
- eSiHLE (NCT01579617)
- Testing
- BUtiful., DIVAS.
- Where
- 6 sites in United States
- Volunteers
- 637 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Urogenital Abnormalities
CDB-2914 for Abnormal Uterine Bleeding in Premenopausal Women
Background: CDB-2914 is a hormone that blocks progesterone, which is necessary for maintaining pregnancy. In women with fibroid tumors, CDB-2914 shrank the tumors. In many cases, menstrual periods stopped during treatment.
- Trial name
- NCT01493791
- Testing
- CDB-2914
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ovarian Cancer
The Role of Regulatory T Cell in Ovarian Cancer: Focus on Relationship Between Clinical Prognosis and Regulatory T Cell Expression
Cancer is the leading cause of mortality in our country, and ovarian cancer becomes a more and more important disease gradually in the field of gynecologic malignancies.
- Trial name
- Tregs (NCT00854282)
- Testing
- Staging surgery or debulking surgery
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
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