Clinical trials: Female Infertility
Infertility
Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
- Trial name
- NCT00680238
- Testing
- Human derived FSH
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Infertility
Drop-out of Infertile Couples: a Large Single Center Experience Over 10 Years
Conducted at a single-center, this prospective-retrospective study focused on all couples who initiated their journey at the Fertility Center of Humanitas Research Hospital, Rozzano (Milan), Italy.
- Trial name
- dropout (NCT06344585)
- Testing
- Drop out patients who had their first access in 2021 were additionally asked to answer to a phone -call questionnaire to assess their motivation of discontinuation
- Where
- Italy
- Volunteers
- 24,773 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Infertility
Aurora Test for ART Donor Patients (AURORA-Donor)
This is a randomized observational study. The main aim is to determine potential oocyte competence predictive mRNA expression profiles in the cumulus cells isolated form individual oocytes.
- Trial name
- NCT06280677
- Testing
- AURORA-Donor
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fertiga, Belgium
Infertility, Female, Pain, Postoperative
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
In this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge…
- Trial name
- NCT03073980
- Testing
- IV Acetaminophen, PO Acetaminophen
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility,Female
Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subsequent COS Cycle of Older Patients With Unexpected Poor or Suboptimal Ovarian Response
A randomized, controlled, pilot study, for Patients ≥ 35 years and < 40 years old with sufficient ovarian reserve parameters (AFC≥ 5), but showed an unexpected poor or suboptimal ovarian response(defined as ≤ 9 retrieved oocytes…
- Trial name
- NCT04178135
- Testing
- rLH
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Infertility
Effectiveness of Generic Versus Reference Cetrorelix Acetate for Ovarian Stimulation Using a Gonadotropin-releasing Hormone（GnRH）Antagonist Protocol in Women Undergoing IVF
The goal of this clinical trial is to compare the clinical outcomes using different cetrorelix acetate in the context of a GnRH antagonist protocol for ovarian stimulation in women undergoing IVF or intracytoplasmic sperm…
- Trial name
- NCT06023602
- Testing
- Generic cetrorelix acetate, Reference cetrorelix acetate
- Where
- China
- Volunteers
- 1,338 people, healthy volunteers welcome
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Female, Trauma, Psychological
Adverse Childhood Experiences and Infertility : ACESI
Adverse childhood experiences can have powerful effects on health and quality of life in adulthood. Thus, having a history of childhood trauma, before the age of 18 (physical aggression, sexual abuse, death of a close person…
- Conditions
- Infertility, Female, Trauma, Psychological, Child Development, Child Abuse
- Trial name
- ACESI (NCT05952427)
- Testing
- ACE Questionnaire
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Infertility, Infertility, Female
GnRH Agonist at Embryo Transfer: IVF Outcomes
In ART (assisted reproductive technology) cycles, embryos are transferred to a woman's uterus after in-vitro fertilization (IVF) in a laboratory.
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- GRAET (NCT03544073)
- Testing
- Saline Solution for Injection, Leuprolide Acetate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Patient Centred Care, Compliance, Treatment
Treatment-related Quality of Life and Patient-Centred Care With Infertility
This study was conducted in a cross-sectional descriptive type with 160 infertile women who were treated in the IVF Clinic of a university hospital between July - October 2020 in order to evaluate the effect of patient-centered…
- Conditions
- Patient Centred Care, Compliance, Treatment, Infertility, Female, Quality of Life
- Trial name
- NCT05078996
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Elif Balkan
Infertility, Female
Impact of a Mindfulness Intervention on Infertile Women Undergoing Assisted Reproductive Technique Treatments
Infertility and its treatments can have a significant impact on women's psychological health. Anxiety has a negative impact on quality of life during treatment and can lead to withdrawal of care.
- Trial name
- EMOT-IVF (NCT04419740)
- Testing
- Mindfulness based psychological intervention
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Infertility, Female, Infertility Unexplained
Pro-inflammatory Cytokines and Implantation Process in Women With Primary Idiopathic Infertility
Infertility is a common, worldwide problem. In about 20% of couples, the causative agent of infertility cannot be identified after routine diagnostic tests.
- Conditions
- Infertility, Female, Infertility Unexplained, Inflammatory Response
- Trial name
- NCT05190250
- Testing
- Pipelle biopsy
- Where
- Poland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Primary Infertility, Mental Health Issue
A Pilot RCT: the Impact of a Virtual MBSR Course on Women With Primary Infertility
We plan to perform a pilot study in which women with primary infertility seeking an initial fertility consultation will be randomized into either a standard treatment group or an 8-week virtual Mindfulness-Based Stress Reduction…
- Conditions
- Primary Infertility, Mental Health Issue, Quality of Life
- Trial name
- NCT05903638
- Testing
- Mindfulness-Based Stress Reduction course
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- One Fertility
Polycystic Ovary Syndrome
History of Polycystic Ovary Syndrome in First-degree Relatives
The aim of this study was to investigate the semen analysis results of male patients with first-degree relatives meeting the diagnostic criteria for PCOS.
- Trial name
- PCOS (NCT06442228)
- Testing
- spermiogram test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Infertility
The Effect of Telehealth Applications on the Level of Anxiety in the Treatment of Infertility
It is expected that 84% natural pregnancy will occur at the end of the first 12 months of sexual intercourse without the use of contraceptive methods.The lack of natural fertility is under the influence of multiple factors.
- Trial name
- NCT05148273
- Testing
- telenursing
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University