Clinical trials: Fertility Disorders
IVF, Fertility Issues
Comparison of Progestin Primed Ovarian Stimulation (PPOS) vs.GnRH Antagonist Methods on IVF Outcomes
The goal of this randomized clinical trial is to compare the effects of two different ovarian stimulation methods: Progestin Primed Ovarian Stimulation (PPOS) vs. GnRH Antagonist in embryologic outcomes of IVF Patients.
- Conditions
- IVF, Fertility Issues, Infertility
- Trial name
- NCT06396390
- Testing
- Progestin, GnRH antagonist
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Nesta Clinic
COVID-19 Virus Infection, Ovarian Function Insufficiency
Does COVİD-19 m-RNA Vaccine Affect Fertility and Over Reserve ?
Women's ovarian reserve and fertility were compared before and after 2 doses of vaccination
- Conditions
- COVID-19 Virus Infection, Ovarian Function Insufficiency, Fertility Disorders, Vaccine Adverse Reaction
- Trial name
- NCT05489367
- Testing
- sars cov 2 biontec vaccine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Fertility Issues
Effect of Collaborative Infertility Counseling on Coping Strategies and Marital Satisfaction
Effect of collaborative infertility counseling on coping strategies and marital satisfaction among women undergoing in vitro fertilization: a randomized control trial
- Trial name
- NCT05658848
- Testing
- Collaborative infertility counseling
- Where
- Egypt
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Port Said University
Polycystic Ovary Syndrome, Healthy
Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism
Background: Polycystic ovary syndrome (PCOS) is as common as 5-10% of all women in Austria. PCOS women frequently present with metabolic disturbances, hyperandrogenism and infertility. New therapy concepts are warranted.
- Conditions
- Polycystic Ovary Syndrome, Healthy, Vitamin D Deficiency
- Trial name
- NCT01721915
- Testing
- Vitamin D supplementation
- Where
- Austria
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Endometrial Cancer Stage I
Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer
The purpose of the study is to investigate the effects of metformin in addition to the conventional progestin therapy in the fertility-sparing treatment of early stage endometrial cancer.
- Trial name
- NCT04792749
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility
Infertility Therapy for Women Age Thirty-eight and Older
This study will determine the most effective treatment strategy for infertile couples who present when the female partner is 38 years to the 43rd birthday and the couples are determined to have a reasonable chance for success.
- Trial name
- FORT-T (NCT00246506)
- Testing
- intrauterine insemination, in vitro fertilization
- Where
- 4 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Covid19, Fertility Issues
Semen Analysis Parameters Following Pfizer's COVID-19 Vaccine
In this study the investigators will explore the effect of the BNT162b2 COVID-19 Vaccine on semen analysis parameters among 75 fertile men.
- Trial name
- NCT04778033
- Testing
- Sperm collection
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hysteroscopy, Hysteroscopy Technique
UTERINE EVALUATION FOR THE IDENTIFICATION OF PATHOLOGY. This Study Will Compare the Intrauterine Pathology Detection Rate Between Standard of Care Hydrosonography, and a New Visual Saline Infusion Device Providing Direct Visualization of the Uterus.
This is a prospective, single center, multiple arm cohort study intended to compare the diagnostic accuracy of a Visual Saline Infusion Device (VSI) device, vs standard of care Hydrosonography in reproductive aged women to…
- Conditions
- Hysteroscopy, Hysteroscopy Technique, Fertility Issues, Uterus Abnormal
- Trial name
- NCT06394752
- Testing
- Visual Saline Infusion, Hydrosonography
- Where
- 2 sites in United States, Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive Health & Gynecology
Infertility, Female, Infertility, Male
Knowledge and Attitude Towards Fertility Among Emirati Infertile Patients
Infertility is on the rise worldwide due to multiple reasons. Proper and timely diagnosis makes the treatment easier and more acceptable by the couple.
- Trial name
- NCT06250231
- Testing
- No intervention
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Spinal Cord Injury
Male Fertility Program
Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen…
- Trial name
- MFP (NCT01467869)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Infertility Female
NR vs. Vitamin E in Enhancing Fertility
This randomized controlled trial enrolled women of advanced maternal age (≥35 years) undergoing ART, who were allocated to an intervention group (oral nicotinamide riboside, NR) or a control group (oral vitamin E, VitE) for a…
- Trial name
- NRVEERSAAM (NCT06950736)
- Testing
- NR, Vit E
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Psychological Experience in Fertility Treatment, Hypogonadism
Male Experiences With Intra Cytoplasmic Sperm Injection (ICSI) and Reduced Sperm Quality
Several international studies indicate that men with reduced semen quality often feel overlooked in the context of fertility treatment.
- Conditions
- Psychological Experience in Fertility Treatment, Hypogonadism, Testosteron Levels, Quality of Life
- Trial name
- NCT07546435
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
Infertility, Female
Physical Activity and Fertility Care Study
Randomized control trial to determine if performing the US Health and Human Services recommended amount of weekly physical activity during ovarian stimulation will differentially affect mental health or clinical outcomes of…
- Trial name
- PACE (NCT04002414)
- Testing
- Sufficient physical activity, Insufficient physical activity
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Female, Reproductive Techniques, Assisted
Use of Autologous Exosomes vs Platelet Growth Factors to Regenerate the Ovary in Women With Infertility (Exosomas2024-1)
Ovarian stromal fibrosis resulting from each ovulation and due to aging is characterized by a decrease in hyaluronic acid concentrations, loss of synthesis and migration proteins CD63 and CD81, decreased miRNA125, miRNA21…
- Trial name
- Exosom2024-1 (NCT06773572)
- Testing
- Autologous Exososomes procedure obtained from the patients' own platelets., Patient group for activated platelet growth factors, the control group
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biotech Fertility C.A.
Fertility Issues, Disclosure
Feasibility Trial of the TELL Tool Intervention
A radical paradigm shift is taking place where technology, notably the explosion in easy accessible direct-to-consumer genetic testing (e.g., 23andMe) and a high consumer interest in genealogy (e.g., Ancestry.com), has hijacked…
- Conditions
- Fertility Issues, Disclosure, Parenting
- Trial name
- NCT04841967
- Testing
- TELL Tool Intervention, eBook Attention Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hypogonadism
Influence of Administration Route of Testosterone on Male Fertility
Exogenously administered testosterone will override the normal negative feedback of endogenous testosterone on the hypothalamus and pituitary.
- Trial name
- NCT00705796
- Testing
- MPP10, testosterone, Testosterone
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Acerus Pharmaceuticals Corporation
Infertility, Female, Fertility Disorders
Comparison of Two PPOS Models for Pituitary Suppression
The scarcity of evidence regarding the interchangeable use of different progestogens poses challenges, particularly in international egg donation and fertility preservation programs where standardizing protocols is crucial for…
- Trial name
- NCT06304220
- Testing
- Cerazet
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- NextFertility
Infertility
Prevalence of Uterine Malformations in Newly Married Unselected Population
Uterine malformation is occur due to the abnormal development of Mullerian canal during embryogenesis and it is known that it reduces the fertility and live birth rate and also increases the abortion and preterm birth rate.
- Trial name
- NCT04686227
- Testing
- 3D Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fertility Disorders, Turner Syndrome
The Danish TURNER Cryopreservation Study
The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers.
- Conditions
- Fertility Disorders, Turner Syndrome, Premature Ovarian Failure
- Trial name
- DANTE (NCT05740579)
- Testing
- laparoscopic cryopreservation of one ovary
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus