Clinical trials: Fertility Disorders, open to volunteers
Polycystic Ovarian Syndrome (PCOS), Infertility
Theta Healing-Based Intervention in Women With Polycystic Ovary Syndrome
This randomized controlled study aims to evaluate the effect of a Theta Healing-based intervention on fertility concerns, self-compassion, and body image in women diagnosed with Polycystic Ovary Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Infertility, Psychological Stress
- Trial name
- NCT07630441
- Testing
- Theta Healing-Based Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ankara Medipol University
Infertility
Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer
This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to three egg retrieval procedures.
- Trial name
- HARVEST (NCT07801105)
- Testing
- CAPA-IVM System, Serial Unstimulated Transvaginal Oocyte Retrieval, ICSI, Blastocyst Culture, PGT-A, Embryo Vitrification/Accumulation, and Single Euploid Embryo Transfer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kevin Doody
Infertility
Food Intake Among Women and Men in Fertility Treatment
Worldwide infertility is highly prevalent and lifestyle factors, such as food intake, could have an essential role in the success of a fertility treatment.
- Trial name
- Food&Fertility (NCT05454046)
- Testing
- Food intake among women and men in fertility treatment
- Where
- 8 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Aalborg University Hospital
Fertility Issues, Blastocyst IVF
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology
To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.
- Conditions
- Fertility Issues, Blastocyst IVF, Embryo Culture
- Trial name
- NCT07050537
- Testing
- Constant oxygen concentration protocols in embryo culture, Sequential oxygen concentration protocols in embryo culture
- Where
- 6 sites in China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Infertility, Microplastics Exposure
Fertility Impact of Microplastics - Advancing Countermeasures and Tracking
FERTIMPACT is a prospective clinical study based on the hypothesis that exposure to micro- and nanoplastics (MNPs) is associated with impaired reproductive function.
- Conditions
- Infertility, Microplastics Exposure, Fertility
- Trial name
- FERTIMPACT (NCT07562958)
- Volunteers
- 1,000 people
- Sponsor
- University of Kragujevac
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Miscarriage
Hysteroscopy vs. Endouterine Aspiration in the Management of Trophoblastic Retention
Introduction: Incomplete early miscarriage is defined as early miscarriage with persistent intrauterine material on ultrasound. Intrauterine retention of trophoblastic debris is not an uncommon phenomenon.
- Trial name
- HARET (NCT05789940)
- Testing
- hysteroscopy, Aspiration
- Where
- 4 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Montpellier
Cervical Cancer, Neoadjuvant Chemoimmunotherapy
Neoadjuvant Chemotherapy Plus Camrelizumab for FIGO Stage IB1 Cervical Cancer
This multicenter, prospective clinical trial is designed to enroll PD-L1 expression-positive patients with stage IB1 cervical cancer who desire fertility preservation to undergo neoadjuvant chemotherapy in combination with a PD-1…
- Conditions
- Cervical Cancer, Neoadjuvant Chemoimmunotherapy, Fertility Preservation
- Trial name
- NCT06289062
- Testing
- Camrelizumab, Cisplatin, Nab paclitaxel
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Cancers
Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
The purpose of this study is to safely remove ovarian tissue in pre-pubertal pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
- Trial name
- NCT05299710
- Testing
- Laparoscopic surgery
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Erin Rowell
Spinal Cord Injury
Male Fertility Program
Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen…
- Trial name
- MFP (NCT01467869)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Quantifying Uterine Elastography in Menstruating Women
This study is aiming to characterize the elasticity of the female reproductive tract including the uterus, cervix and ovary using shear wave elastography at different times during the menstrual cycle and define the standard…
- Trial name
- QUEST (NCT06816381)
- Testing
- Shear wave elastography measurements
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Oncological Disease, Fertility Preservation
Ovulation Induction With GnRH Analogue or Dual Trigger?
Most medically assisted procreation (ART) techniques, including oocyte cryopreservation for fertility preservation, involve controlled ovarian stimulation.
- Trial name
- NCT07546136
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fertility, Fecundability
Physical Activity, Fertility, and Spontaneous Abortion in Danish Couples Trying to Conceive
Physical activity in both the preconception period and during pregnancy may enhance the probability of getting pregnant and reduce the risks of complications during pregnancy.
- Conditions
- Fertility, Fecundability, Time-to-Pregnancy, Spontaneous Abortion
- Trial name
- SF/Activity (NCT06705712)
- Testing
- Use of activity trackers and motivational conversations to enhance focus on physical activity among women trying to conceive.
- Where
- Denmark
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Endometriosis
Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation.
- Trial name
- NCT07182643
- Testing
- Endometrial fluid, Endometrial biopsy, Follicular fluid
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Infertility, Female
Impact of a Web-Based Mind-Body Awareness Program on Women Undergoing Infertility Treatment
The goal of this two-group parallel randomized controlled study is to determine the effect of a web-based mind-body-based awareness program based on Meleis Transition Theory on fertility awareness and readiness levels in women…
- Trial name
- NCT06585137
- Testing
- Web-Based Mind-Body Based Awareness Program
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University
Sickle Cell Anemia
Serial Assessment of Fertility Experiences
The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children.
- Trial name
- SAFE (NCT07116772)
- Where
- 3 sites in Dominican Republic, Jamaica and 1 more
- Volunteers
- 250 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Endometriosis, Infertility
Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility
The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility.
- Trial name
- ENDOFERT (NCT02948972)
- Testing
- complete surgery, In vitro fertilization without surgery
- Where
- 5 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Breast Neoplasms, Pregnancy
PREgnancy and FERtility Registry
The PREgnancy and FERtility (PREFER) study is a comprehensive program aiming to optimize care and improve knowledge around the topics of fertility preservation and pregnancy issues in young breast cancer patients.
- Conditions
- Breast Neoplasms, Pregnancy, Fertility Preservation
- Trial name
- PREFER (NCT02895165)
- Where
- 23 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Endometritis, Infertility
Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis
Chronic endometritis (CE) is a long-lasting inflammation of the lining of the uterus. Many women with CE do not have symptoms, but the condition may affect fertility, embryo implantation, and pregnancy outcomes.
- Conditions
- Endometritis, Infertility, Hysteroscopy, Pregnancy Disease
- Trial name
- MORE (NCT07603492)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady