Clinical trials: Fertility Issues
Microbial Colonization, Dysbiosis
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
The aim of this study is to determine the efficacy of an oral nutraceutical with probiotics in restore vaginal health.
- Conditions
- Microbial Colonization, Dysbiosis, Fertility Issues
- Trial name
- PROSALVAG (NCT05176535)
- Testing
- FertyBiotic Balance
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fertypharm
Infertility, Infertility Secondary
Sperm Preparation Prior to Intrauterine Insemination Study
This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.
- Conditions
- Infertility, Infertility Secondary, Infertility Unexplained, Anovulation
- Trial name
- PIoUS (NCT05693220)
- Testing
- Zymot Multi sperm separation device, Density gradient centrifugation
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of California, San Francisco
Cancer, Fertility Issues
Intervening on Women's Health for Rural Young Cancer Survivors
The purpose of this pilot study is to evaluate the feasibility of a multi-component intervention to improve young female cancer survivors' engagement in goal-concordant reproductive health care.
- Conditions
- Cancer, Fertility Issues, Contraception
- Trial name
- NCT06664034
- Testing
- Multi-component reproductive health care intervention
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Cancer, Fertility Issues
Impact of Gonadotoxic Therapies on Fertility
The goal of this observational study is to learn how gonadotoxic treatments (chemotherapies, radiotherapies or immunotherapies) affect the fertility status of participants with cancer.
- Conditions
- Cancer, Fertility Issues, Fertility Preservation, Toxicity Due to Chemotherapy
- Trial name
- FertiTOX (NCT05885048)
- Testing
- Blood samples for analysis, Sperm samples for analysis, Satisfaction evaluation
- Where
- Switzerland
- Volunteers
- 7,000 people
- Sponsor
- Michael von Wolff
Fertility Issues, Preconception Injuries
Health Promotion Model, Fertility Awareness, Preconception Knowledge and Attitude
The effect of education given to preconceptional women in line with the health promotion model on fertility awareness, preconceptional knowledge and attitude levels
- Conditions
- Fertility Issues, Preconception Injuries, Health Behavior
- Trial name
- NCT06690554
- Testing
- Education Group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Infertility, Fertility Issues
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
The goal of this study is to compare the difference in clinical pregnancy, miscarriage and livebirth rate between day 6 euploid blastocyst transfer on the 6th and the 7th day of progesterone exposure in Hormonal Replacement…
- Conditions
- Infertility, Fertility Issues, Infertility, Female
- Trial name
- NCT05980091
- Testing
- Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Endometrial Carcinoma, Obese
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
To investigate the efficacy of weight management plus megestrol acetate in obese patients with early endometrioid carcinoma（EEC）asking for fertility-sparing treatment
- Conditions
- Endometrial Carcinoma, Obese, Overweight, Fertility Issues
- Trial name
- NCT05316467
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xiaojun Chen
Atypical Endometrial Hyperplasia, Fertility Issues
Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia
To investigate the efficacy of weight management plus levonorgestrel intrauterine system (LNG-IUS) or megestrol acetate (MA) in obese patients with endometrial atypical hyperplasia (EAH) asking for conservative therapy.
- Conditions
- Atypical Endometrial Hyperplasia, Fertility Issues, Overweight and Obesity
- Trial name
- NCT05316493
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xiaojun Chen
Fertility Issues, Blastocyst IVF
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology
To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.
- Conditions
- Fertility Issues, Blastocyst IVF, Embryo Culture
- Trial name
- NCT07050537
- Testing
- Constant oxygen concentration protocols in embryo culture, Sequential oxygen concentration protocols in embryo culture
- Where
- 6 sites in China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Fertility Issues, Emotional Stress
Frame Support Study
This is a randomized, controlled pilot study evaluating an intervention of non-significant risk. Potential subjects will be women who have completed an initial new patient consultation at one of the participating fertility…
- Trial name
- NCT07083700
- Testing
- Frame Access
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Fertility Disorders, Fertility Issues
Fertility After Uterine Artery Embolization
Uterine leiomyomas (or fibroids) are a common disease (30% of women over 35 years of age) in women of childbearing age and can cause various symptoms such as menometrorrhagia, dysmenorrhoea, pelvic pain and heaviness, and…
- Conditions
- Fertility Disorders, Fertility Issues, Myoma;Uterus, Uterine Artery Embolisation
- Trial name
- FERTI-EMBOL (NCT05271981)
- Testing
- Retrospective data collection, Phone interview
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Reproductive Issues, Fertility Issues
Towards Optimal Fertility, Fathering and Fatherhood studY
This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood…
- Trial name
- TOFFFY (NCT06293235)
- Testing
- Lifestyle and metabolic indicators
- Where
- Singapore
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Atypical Endometrial Hyperplasia, Obesity
Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia
To study if polyethylene glycol loxenatide plus levonorgestrel-releasing intrauterine system (LNG-IUS) will improve response rates in patients with endometrial atypical hyperplasia.
- Conditions
- Atypical Endometrial Hyperplasia, Obesity, Fertility Issues
- Trial name
- NCT05172999
- Testing
- levonorgestrel-releasing intrauterine system, Polyethylene Glycol Loxenatide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Hiv, Contraception
Mobile Phone Messaging to Improve Reproductive Health for Women Living With HIV in Kenya (Mobile WACh Empower)
Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes.
- Conditions
- Hiv, Contraception, Fertility Issues
- Trial name
- NCT05285670
- Testing
- Digital counseling plus interactive two-way SMS dialogue
- Where
- 10 sites in Kenya
- Volunteers
- 3,310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Fertility Issues, Reproductive Issues
The Stanford Egg Freezing Study
The purpose of this study is to see if the investigators can obtain non-inferior clinical outcomes (similar numbers of oocytes) using the Cardinal protocol, a cost-conscious, low-intensity egg freezing protocol, compared to other…
- Trial name
- NCT05842070
- Testing
- Low-Intensity Egg Freezing Protocol, High-Intensity Egg Freezing Protocol
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Stanford University
Cancer, Fertility Issues
Outcome Evaluation After Fertility Preservation
It is important to evaluate outcomes after different fertility preservation strategies. Therefore, this study aims to assess the outcomes after different fertility preservation strategies and identify any factors that may affect…
- Trial name
- NCT06043609
- Testing
- This is an observational cohort study
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Pregnancy Related, Fertility Issues
Luteal Phase Support in IUI MOH Treatment Luteal Phase Support in IUI MOH Treatment
The LUMO study is a multicenter, randomized controlled trial that evaluates the effectivity of luteal phase support in MOH/IUI treatment.
- Conditions
- Pregnancy Related, Fertility Issues, Luteal Phase Defect, Infertility Unexplained
- Trial name
- LUMO (NCT05080569)
- Testing
- Progesterone Vaginal Product
- Where
- Netherlands
- Volunteers
- 1,008 people
- Sponsor
- UMC Utrecht
Fertility Issues, Embryo Implantation
Rescue Progesterone Supplementation During Frozen Embryo Transfer
Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet…
- Conditions
- Fertility Issues, Embryo Implantation, Frozen Embryo Transfer
- Trial name
- P4R (NCT05555121)
- Testing
- Progesterone Effervescent Vaginal Tablet
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Clinique Ovo
Ovarian Diseases, Fertility Issues
A Novel Ovarian Reserve Monitoring Algorithm for Patients at Risk of Ovarian Injury From Gonadotoxic Therapy
This is an observational cohort study to examine the use of a novel proposed ovarian reserve monitoring algorithm to (1) identify patients who are at risk of DOR and POI from gonadotoxic therapy, (2) minimize time from treatment…
- Conditions
- Ovarian Diseases, Fertility Issues, Gonadal Disorders
- Trial name
- MA (NCT05048654)
- Sponsor
- University of Colorado, Denver
Fertility Issues
Testicular Tissue Cryopreservation (TTC)
The "Testicular Tissue Cryopreservation" study is open to a subset of patients facing disease or treatment regimens that could lead to infertility (gonadotoxic therapies).
- Trial name
- TTC (NCT06387498)
- Testing
- Testicular tissue biopsy and cryopreservation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver