Clinical trials: Fertilization
InVitro Fertilization, Gonadotropins
rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
This study aims to compare two commonly used hormone treatments for women undergoing IVF. All participants will receive a stimulation protocol that includes dydrogesterone, a medication used to safely control natural hormone…
- Trial name
- DYG-GONA (NCT07348757)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Infertility; In Vitro Fertilization; Embryo Development
Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A).
- Trial name
- AH-PGTA (NCT07154875)
- Testing
- Laser-Assisted Hatching
- Where
- Vietnam
- Volunteers
- 141 people
- Sponsor
- Hoang Minh Ngan
Human Sperm Survival Assay, Embryotoxicity
The Human Sperm Survival Assay (HSSA) as an Internal Quality Control for the IVF Consumables (REPROTOX 2)
The main embryotoxicity quality controls are the mouse embryo test (MEA = Mouse Embryo Assay) and the human sperm survival test (HSSA = Human Sperm Survival Assay).
- Conditions
- Human Sperm Survival Assay, Embryotoxicity, in Vitro Fertilization
- Trial name
- REPROTOX 2 (NCT05100784)
- Testing
- HSSA test
- Where
- France
- Volunteers
- 826 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Vitamin D Insufficiency, In Vitro Fertilization and Embryo Transfer
An Investigation of the Effect of Vitamin D Level During Frozen Embryo Transfer (FET) in IVF and Pregnancy Outcomes
Vitamin D is best known for keeping our bones healthy, but growing research suggests it may also play a role in fertility. Many In vitro fertilization (IVF) clinics now routinely check vitamin D levels and prescribe supplements…
- Trial name
- VitD in FET (NCT07681115)
- Testing
- No Intervention: Observational Cohort
- Where
- United Arab Emirates
- Volunteers
- 126 people
- Sponsor
- Fakih IVF Fertility Center
Abnormal Fertilization, Infertility
Outcomes of Embryos Created From Abnormally Fertilized Oocytes
The purpose of this study is to retrospectively analyze data from multiple clinics in a fertility network on embryos that were created from abnormally fertilized oocytes (AFO) including the rate of transfers and any clinical…
- Trial name
- NCT07666243
- Volunteers
- 92 people
- Sponsor
- Inception Fertility Research Institute, LLC
In Vitro Fertilization (IVF), Infertility
Working IVF Patients' Quality of Life
Infertility affects approximately 1 in 6 couples and may require the use of Medically Assisted Reproduction techniques. In France, there were more than 60,000 in vitro fertilization (IVF) attempts in 2016.
- Trial name
- WIQoL (NCT04966091)
- Testing
- Completion of questionnaires
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Ongoing Pregnancy Rate, Vitamin D
The Effect of Vitamin D on in Vitro Fertilization Outcome
To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small.
- Conditions
- Ongoing Pregnancy Rate, Vitamin D, in Vitro Fertilization
- Trial name
- NCT02361827
- Testing
- Embryo transfer
- Where
- China
- Volunteers
- 688 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Infertility, In Vitro Fertilization (IVF)
The Impact of Myomectomy on IVF Outcomes: A Multicenter Randomized Controlled Trial
Uterine fibroids are the most common benign tumors of the female reproductive system and are frequently encountered in women of reproductive age.
- Conditions
- Infertility, In Vitro Fertilization (IVF), Uterine Myomas, Leiomyomas, or Fibromas
- Trial name
- MIO (NCT07578623)
- Testing
- Myomectomy
- Volunteers
- 792 people
- Sponsor
- Peking Union Medical College Hospital
Incubator Stay, Total Blastulation
Impact of Dry vs Humidified Culture Conditions on Blastocyst Development and Aneuploidy: A Time-lapse Sibling Oocyte Study
IVF incubators are essential for maintaining the micro-environment required for embryo development. Incubator technology has progressed from early humidified box systems to benchtop and now time-lapse platforms, driving the…
- Conditions
- Incubator Stay, Total Blastulation, Blastocyst Quality, Biopsy Rate
- Trial name
- NCT07270250
- Testing
- K- system incubator
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, In Vitro Fertilization
Video-Supported Medication Education for Women Undergoing In Vitro Fertilization (IVF): Quality of Life and Psychosocial Effects
Reproductive health problems, particularly infertility, affect 48 million couples globally, ranking as the fifth most serious global obstacle for women.
- Conditions
- Infertility, In Vitro Fertilization, Psychosocial Support Systems, Quality of Life
- Trial name
- NCT06515275
- Testing
- Education via video (QR code links)
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Fertilization in Vitro
Interest of Audiovisual Distraction in the Management of Anxiety and Pain During Oocyte Retrieval
Oocyte retrieval procedure for in vitro fertilization is a source of anxiety for patients. Local anaesthesia or sedation are commonly used to manage many situations of anxiety, including the oocyte retrieval.
- Trial name
- Happy-Fiv (NCT04213781)
- Testing
- HappyMed Video Glasses, Propofol, Sufentanil
- Where
- France
- Volunteers
- 36 people
- Sponsor
- CMC Ambroise Paré
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Infertility, in Vitro Fertilization
the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients
The goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia.
- Conditions
- Infertility, in Vitro Fertilization, Mental Health, Anesthesia, General
- Trial name
- NCT06475690
- Testing
- Psychological interventions
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Fertilization, Fertilization in Vitro
BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve.
- Trial name
- BEST (NCT06433518)
- Testing
- Ovulation Trigger Timing Based on Leading Follicle Size in POSEIDON Group 4 IVF Patients
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Centrum Clinic IVF Center
Pregnancy, Immune Tolerance
Mechanisms of Maternal Immune Tolerance in Early Pregnancy
This study explores the mechanisms of maternal immune tolerance in early pregnancy by characterizing immune cell profiles and functional pathways during the first trimester.
- Conditions
- Pregnancy, Immune Tolerance, In Vitro Fertilization
- Trial name
- NCT07297394
- Testing
- Blood sampling
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
IVF, In Vitro Fertilization
The Effect of a Four-Week Hatha Yoga Intervention to Improve Quality of Life, Anxiety, and Depressive Symptoms in Individuals Undergoing Assisted Reproductive Technology (ART) Treatment
The goal of this clinical trial is to learn if a four-week yoga program works to improve quality of life in people undergoing IVF (In Vitro Fertilization).
- Conditions
- IVF, In Vitro Fertilization, Quality of Life (QOL), Anxiety
- Trial name
- NCT07415850
- Testing
- Yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Villanova University
Infertility, Male Infertility
To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.
The goal of this prospective, multicenter randomized controlled clinical trial is to evaluate whether the SwimCount Harvester microfluidic sperm preparation device can achieve equivalent or superior clinical outcomes compared to…
- Conditions
- Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate
- Trial name
- NCT07369362
- Testing
- microfludics semen processing device
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- MotilityCount aps
Subclinical Hypothyroidism, Infertility
Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation
Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine (fT4) levels.
- Conditions
- Subclinical Hypothyroidism, Infertility, Assisted Reproductive Technology, In Vitro Fertilization (IVF)
- Trial name
- LESI (NCT07257250)
- Where
- 2 sites in Vietnam
- Volunteers
- 900 people
- Sponsor
- Mỹ Đức Hospital