Clinical trials: Fertilization
Infertility
A Trial Evaluating Autologous Endometrial Co-Culture Versus Conventional Medium in the Treatment of Infertility
One of the main factors in the success of in-vitro fertilization is the quality of the environment of the embryo. In contrast to maternal age, the environment in which the embryo develops is a modifiable factor.
- Trial name
- OvoGEN (NCT01886118)
- Testing
- Endometrial biopsy, Autologous Endometrial Co-Culture, Conventional media culture
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- Clinique Ovo
Women With Fertility Disorder
Effect of Glucagon on Uterine Contractility at the Time of Embryo Transfer in in Vitro Fertilization
The success of in vitro fertilization is based mainly on uterine implantation embryo. An excessive uterine contractility may interfere with implantation by a movement of the embryo in the uterus.
- Trial name
- NCT01674283
- Testing
- Glucagon
- Where
- Canada
- Sponsor
- Clinique Ovo
In Vitro Fertilization, Controlled Ovarian Stimulation
N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in COS
This project wants to determinate whether there is a relationship between the N680S polymorphism genotype of the FSHR gene and the nature of the FSH used in controlled ovarian stimulation.
- Trial name
- NCT04122729
- Where
- 12 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Angelini Farmacéutica
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Infertility
Eeva™ System Study: Noninvasive Recording and Visualization of Individual Embryos Cultured to Blastocyst Stage
The purpose of this study is to demonstrate that the Eeva System may be used to identify embryos on Day 2 that are most likely to form blastocysts.
- Trial name
- Eeva (NCT01369446)
- Testing
- Eeva System Study
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Progyny, Inc.
In Vitro Fertilization
Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
To collect the outcome of frozen-thawed embryo transfer cycles after the embryos are cryopreserved up to at least 1 year in Trial P05787 (NCT00696800), in order to estimate the cumulative pregnancy rate for each treatment group.
- Trial name
- NCT00702273
- Testing
- 150 µg Corifollitropin Alfa, 200 IU RecFSH/Follitropin beta (Days 1 to 7), 200 IU RecFSH/Follitropin beta (Days 8 to hCG)
- Volunteers
- 344 people
- Sponsor
- Organon and Co
Infertility (IVF Patients)
Study of Abnormally Fertilized Embryos
The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles.
- Trial name
- SAFE (NCT06940973)
- Testing
- Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Igenomix
Infertility, In Vitro Fertilization
Investigate Dose of Org 36286 to Initiate Multiple Follicular Growth in a Controlled Ovarian Hyperstimulation Protocol for IVF or IVF/ICSI (P07015)
The primary objective of this trial was to investigate the appropriate dose of a single injection of Org 36286 to initiate multifollicular growth for the first seven days in a controlled ovarian hyperstimulation (COH) protocol…
- Trial name
- NCT00702806
- Testing
- Org 36286, Puregon®, Orgalutran®
- Volunteers
- 99 people
- Sponsor
- Organon and Co
Infertility
A Phase IV, Prospective, Observational, Open Label, Single Centre Cohort Trial to be Conducted in Norway During One Year to Assess the Cumulative Pregnancy Rate in a New Series of In-vitro Fertilization (IVF) Treatment Cycles Following Three or More Previous IVF Treatment Cycles Without Live Birth
The primary objective of this observational study is to assess the cumulative rate of ongoing pregnancy at 10 ±2 weeks after hCG administration in a new series of IVF-treatment cycles in a total of 176 subjects, who have…
- Trial name
- NCT01071148
- Where
- Norway
- Volunteers
- 166 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Infertility, Male
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
Multi-centered, randomized controlled study, evaluating the safety and efficacy of the Ohana IVF Sperm Preparation Kit vs. a standard IVF sperm preparation kit.
- Trial name
- SPRING (NCT04142112)
- Testing
- Ohana IVF Sperm Preparation Kit (OHB035), Standard IVF Preparation Kit (OHB037)
- Where
- 7 sites in United States
- Volunteers
- 83 people
- Sponsor
- Ohana BioSciences
Pregnancy
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established During Phase II Clinical Trials of Org 36286 (Study 38817)(P06054)(COMPLETED)
The objective of this trial was to evaluate whether Org 36286 treatment in any Phase IIa clinical development trial of Org 36286 for OI or COH in assisted reproductive treatment programs was safe for pregnant subjects and their…
- Trial name
- NCT00702195
- Testing
- Org 36286 (corifollitropin alfa), recFSH
- Volunteers
- 29 people
- Sponsor
- Organon and Co
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban compared to placebo on uterine contractions on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- EFFORT (NCT01043120)
- Testing
- Barusiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovarian Syndrome, Infertility
Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)
This multicenter, randomized, open-label exploratory study will be performed in approximately 200 polycystic ovary syndrome (PCOS) but otherwise healthy females undergoing in vitro fertilization (IVF).
- Trial name
- NCT00805935
- Testing
- Menotropin, Progesterone vaginal insert, Follitropin beta
- Where
- 6 sites in United States
- Volunteers
- 110 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Eeva™ Pregnancy Pilot Study (PPS)
The purpose of this clinical investigation is to gather pilot data to evaluate the impact of using Eeva™, a time-lapse enabled embryo test, in combination with traditional morphology on clinical pregnancy rates.
- Trial name
- PPS (NCT02218255)
- Testing
- Eeva™ results
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Progyny, Inc.
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in Normal Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in normal responders.
- Trial name
- NCT00963625
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Pregnancy, Neonates
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial 38833 (P05783)
The objective of this trial is to evaluate whether corifollitropin alfa (MK-8962, Org 36286) treatment for the induction of multifollicular growth in women undergoing Controlled Ovarian Stimulation (COS) prior to in vitro…
- Trial name
- Care (NCT00702520)
- Testing
- Corifollitropin alpha (MK-8962, Org 36286) 100 ug, Corifollitropin alpha (MK-8962, Org 36286) 150 ug, Triptorelin
- Volunteers
- 15 people
- Sponsor
- Organon and Co
Male Infertility
Andrositol® TEST as Diagnostic Assay to Predict the Fertilization Potential in IVF
Andrositol® test allows to obtain additional information besides the WHO parameters and to evaluate the semen energetic status. The diagnosis is performed by analyzing the semen at two different time points: before the treatment…
- Trial name
- NCT03677011
- Testing
- Andrositol® Test
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Lo.Li.Pharma s.r.l
Female Infertility
Phase IV Study to Evaluate the Efficacy and Safety of Fang Le Shu Compared to Guo Na Fen for Controlled Ovarian Stimulation in Infertile Women Undergoing in Vitro Fertilization-embryo Transfer (IVF-ET).
The aim of this randomized, open-label, active-controlled, parallel-group, multicenter, phase IV study is to assess the efficacy and safety of Fang Le Shu versus Guo Na Fen used for controlled ovarian stimulation in infertile…
- Trial name
- NCT06921395
- Testing
- Fang Le Shu (Follitrope), Guo Na Fen (Gonal-F)
- Where
- China
- Volunteers
- 248 people
- Sponsor
- LG Chem
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban and atosiban compared to placebo on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- OVANCON (NCT00587327)
- Testing
- Barusiban, Atosiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility, Endometritis
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic.
- Conditions
- Infertility, Endometritis, Abortion, Spontaneous
- Trial name
- NCT01762098
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Clinique Ovo