Clinical trials: Fetal Acidemia
Pregnancies At Increased Risk of Preterm Birth
Development of a Predictive Model of Fetal PH At Birth from Novel Variables Derived from Cardiotocographic Tracing
The goal of this observational study is to build a predictive model of fetal acidosis based on variables from the cardiotocographic tracing recorded during labor in participants undergoing spontaneous or induced delivery with…
- Trial name
- NCT06720363
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Neonatal Acidemia and Hypoxia
Evaluation of Neonatal Acute Hypoxia at Delivery Using Fetal Physiology and Eucapnic pH Assessment
This study aims to improve understanding of how fetuses respond to oxygen deprivation during labor by re-evaluating cardiotocography (CTG) recordings using a physiology-based interpretation approach and comparing these findings…
- Trial name
- NOAH (NCT07629271)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aortocaval Compression, Fetal Acidosis
Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine
This study aims to compare the neonatal acid-base status of women who remain supine horizontal, with women who are tilted to the left side by 15° during elective cesarean delivery at term under spinal anesthesia, with systolic BP…
- Trial name
- NCT02243423
- Testing
- SUPINE, TILT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infant, Newborn, Hypoxia, Brain
Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)
The Optimizing Cooling trial will compare four whole-body cooling treatments for infants born at 36 weeks gestational age or later with hypoxic-ischemic encephalopathy: (1) cooling for 72 hours to 33.5°C; (2) cooling for 120…
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic
- Trial name
- NCT01192776
- Testing
- Whole-body Cooling
- Where
- 19 sites in United States
- Volunteers
- 364 people
- Sponsor
- NICHD Neonatal Research Network
Pregnancy, Obstetric Labor
Fetal ST Segment and T Wave Analysis in Labor
The purpose of this research is to test a new instrument, called a fetal STAN monitor, that may be used during labor to monitor the electrical activity of the baby's heart.
- Conditions
- Pregnancy, Obstetric Labor, Parturition
- Trial name
- STAN (NCT01131260)
- Testing
- fetal STAN monitor
- Where
- 13 sites in United States
- Volunteers
- 11,108 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Cesarian Section, Neonatal and Perinatal Conditions
Transplacental Neonatal Transfer of Lidocaine During Urgent Caesarean Delivery
Lidocaine is commonly administered through an existing labor epidural catheter to provide surgical anesthesia for urgent cesarean delivery.
- Conditions
- Cesarian Section, Neonatal and Perinatal Conditions, Epidural Anesthesia, Lidocaine Toxicity
- Trial name
- Lidocaine TNT (NCT07826468)
- Testing
- Category Lucas 1 cesarian section, Category 3 Lucas Cesarian section
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Hôpital de la Croix-Rousse
Fetal Hypoxia, Fetal Distress
Trans-abdominal Fetal Pulse Oximetry
The Raydiant Oximetry Sensing System (Lumerah) is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy.
- Conditions
- Fetal Hypoxia, Fetal Distress, Fetal Acidemia, Fetal or Neonatal Effect of Complication of Labor
- Trial name
- NCT05147584
- Testing
- Dual fetal oxygen sensors
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
Fetal Hypoxia, Fetal Monitoring
Evaluation of the Fetal Response to Intrapartum Digital Fetal Scalp Stimulation to Identify Intrapartum Fetal Hypoxia.
The main objective of this study is to evaluate whether digital fetal scalp stimulation improves fetal well-being in fetuses with suspicious or pathological cardiotocographic recordings, showing an improvement in…
- Trial name
- NCT07035028
- Testing
- Digital fetal scalp stimulation dFSS
- Where
- 2 sites in Spain
- Volunteers
- 182 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Hypotension
Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
Hypotension is one of the most common adverse effects of spinal anesthesia for cesarean deliveries, affecting as many as 55-90% of mothers.
- Trial name
- NCT04053478
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Fetal Hypoxia, Fetal Acidemia
Dual System Study: Transvaginal Fetal Pulse Oximetry Measurement Systems
The objective of this study is to collect and compare fetal SpO2 waveforms and reference values to inform algorithm development for signal qualification and FSpO2 calculations. Subjects are women in labor.
- Trial name
- NCT07296419
- Testing
- Fetal Pulse Oximetery
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Fetal Hypoxia, Fetal Distress
Gemini Flash 3.6 Versus Human Observers for FIGO-Based Interpretation of Intrapartum Cardiotocography
Cardiotocography (CTG) is the standard method for monitoring fetal heart rate and uterine contractions during labor to detect signs of fetal hypoxia.
- Conditions
- Fetal Hypoxia, Fetal Distress, Low Apgar Score, Neonatal Acidemia
- Trial name
- NCT07827222
- Volunteers
- 415 people
- Sponsor
- Assiut University
Fetal Acidemia
Application of High-flow Nasal Oxygen in Cesarean Section
The study propose that the using the high-flow nasl oxygen to provide oxygen for maternal can improve the fetal acidemia and the neonatal outcomes during cesarean section with combined spinal-epidural anesthesia.
- Trial name
- NCT05921955
- Testing
- Optiflow high-flow nasal cannula system
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Evidence-Based Practice, Labor; Prolonged, Second Stage
Open-glottis Pushing Technique Versus the Valsalva Pushing Technique in the Second Stage of Labor
Pushing has been discussed for decades, primarily in terms of facilitating care in the second stage of labor and maternal/fetal outcomes. Valsalva-type pushing is the pushing performed by a pregnant woman by holding her breath.
- Conditions
- Evidence-Based Practice, Labor; Prolonged, Second Stage, Labor, Fetal Acidosis Complicating Labor and Delivery
- Trial name
- NCT06210087
- Testing
- Spontaneous pushing technique
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Fetal Acidemia
Monitoring of Babies' Heart Rates During Labour Using Mobile Monitors
The study has been designed as a prospective, non-randomised, single centre study to determine the predictive utility of Short Term Variation (STV) of the Fetal Heart Rate (FHR)from the intrapartum FHR data collected using the…
- Trial name
- NCT03922854
- Testing
- Non-interventional data collection only
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust