Clinical trials: Fetal Growth Restriction (FGR)
Hypoxia, Anemia
Diastolic Deceleration Area in Early-onset FGR
DDA is a new Doppler parameter aiming to assess fetal well-being in-utero. Early-onset SGR is a specific subgroup of fetuses where the clinical application of this Doppler modality could play an important role in the detection of…
- Trial name
- NCT05820464
- Testing
- DDA Doppler
- Where
- Bulgaria
- Volunteers
- 300 people
- Sponsor
- Orthogyn Medical Center, Bulgaria
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Fetal Growth Restriction (FGR)
AI-Based Ultrasound Prediction of Pregnancy Outcomes in Placental-Related Fetal Growth Restriction (MVM-FGR): A Prospective Cohort Study
The goal of this prospective cohort study is to enroll pregnancies complicated by placental-related fetal growth restriction (FGR) and to develop predictive models for adverse short- and long-term outcomes.
- Trial name
- NCT07473739
- Testing
- new ultrasound index and MRI
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Fetal Growth Restriction
COmputerized CTG Self-MOnitoring Versus Standard Doppler Assessment in Late-onset FGR: COSMOS Study
Fetal growth restriction is one of the major causes of perinatal morbidity, mortality and adverse neurological outcome. Growth restricted fetuses do not reach their potential due to multiple factors.
- Trial name
- COSMOS (NCT05034861)
- Testing
- cCTG, Doppler
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Fetal Growth Restriction (FGR)
DIFFUSION WEIGHTED MRI FINDINGS IN FETUSES WITH AND WITHOUT FETAL GROWTH RESTRICTION
This prospective observational study aims to compare fetal brain diffusion-weighted magnetic resonance imaging (DWI) findings in fetuses with and without fetal growth restriction (FGR) and to evaluate the association between…
- Trial name
- NCT07769957
- Testing
- Diffusion-weighted fetal brain MRI
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Intrauterine Growth Restriction (IUGR), Fetal Growth Restriction (FGR)
Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction
Early-onset placental intrauterine growth restriction (EO IUGR) is associated with a high risk of perinatal morbidity and mortality.
- Trial name
- STRIDERCan (NCT02442492)
- Testing
- Sildenafil
- Where
- 5 sites in Canada
- Volunteers
- 21 people
- Sponsor
- University of British Columbia
Hypoxia, Anemia
Diastolic Deceleration Area in Late-onset FGR
DDA is a new Doppler parameter aiming to assess fetal well-being in-utero. Late-onset FGR is a specific subgroup of fetuses where the clinical application of this Doppler modality could play an essential role in detecting…
- Trial name
- NCT05837195
- Testing
- DDA Doppler
- Where
- Bulgaria
- Volunteers
- 300 people
- Sponsor
- Orthogyn Medical Center, Bulgaria
Pre-eclampsia, Gestational Diabetes Mellitus (GDM)
Placental Biology in Health and Disease
Pre-eclampsia (PET) is a condition characterised by high blood pressure and damage to other organs, and is a leading cause of maternal and fetal complications such as fetal growth restriction (FGR).
- Conditions
- Pre-eclampsia, Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), Pregnancy Induced Hypertension (PIH)
- Trial name
- NCT07470320
- Testing
- There are no interventions for this study
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Speckle Tracking, Fetus Fetus
Speckle Tracking Echocardiography in Infants, Prenatally and Postnatally
Comparison of prenatal and postnatal cardiac function assessed by echocardiography using pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between foetuses/neonates with a structural heart disease…
- Conditions
- Speckle Tracking, Fetus Fetus, Neonate, Structural Heart Disease
- Trial name
- STIPP (NCT05601375)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Fetal Growth Restriction (FGR), Placental Insufficiency
Placental Imaging Techniques
The goal of this proof-of-concept, case-control, clinical trial is to evaluate the efficacy of using two newer ultrasound technologies, quantitative ultrasound (QUS) and ultrafast power Doppler imaging (uPDI), to evaluate the…
- Conditions
- Fetal Growth Restriction (FGR), Placental Insufficiency, Preeclampsia, Still Births
- Trial name
- NCT06861309
- Testing
- ultrafast power Doppler imaging (uPDI) / quantitative ultrasound (QUS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Carilion Clinic
Early Fetal Growth Restriction (FGR)
Characterization of Neonatal Clinical Risk Profiles in Relation to Prenatal Obstetric Characteristics in Infants With Early-FGR Secondary to Doppler Flowmetry Alterations
This study aims to characterize neonatal clinical risk profiles in relation to prenatal obstetric characteristics in infants with early fetal growth restriction (early-FGR) secondary to Doppler flowmetry alterations.
- Trial name
- NEO-FGR (NCT07466693)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fetal Growth Restriction, Small for Gestational Age at Delivery
Evaluation of HALP Score in Distinction Between FGR and SGA
Fetal Growth Restriction (FGR) and Small for Gestational Age (SGA) are two conditions that can happen when a baby doesn't grow as much as expected during pregnancy.
- Trial name
- NCT05814198
- Testing
- HALP score
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Foetal Growth Restriction
Maternal Serum Vascular Endothelial Growth Factor in Pregnant Women With Foetal Growth Restriction
In this study we explore To explore the role of maternal serum vascular endothelial growth factor (VEGF) in pregnancies complicated by foetal growth restriction.
- Trial name
- VEGF in FGR (NCT02245477)
- Testing
- obstetric Ultrasound, serum Vascular Endothelial Growth Factor
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Fetal Growth Retardation
STV Analysis Versus Visual Evaluation of Cardiotocography in FGR
This stepped wedge cluster randomized clinical trial investigates whether in pregnant women with severe, early-onset fetal growth restriction, the use of STV analysis in fetal monitoring improves the chances of perinatal…
- Trial name
- SAVEFGR (NCT06010238)
- Testing
- Short term variation, Visual interpretation
- Volunteers
- 800 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intrauterine Growth Restriction, Fetal Growth Restriction (FGR)
Diagnostic Value of sFlt-1/PlGF Ratio for the Etiology of Intra Uterine Growth Restriction - ANGIOPAG
The main aim of this project is to determine the Placental Growth Factor and Vascular Endothelial Growth Factor ratio's performance (sFlt-1/PlGF) for the etiological diagnosis of vascular Intrauterine growth restriction (IUGR)…
- Trial name
- ANGIOPAG (NCT05151289)
- Testing
- Blood test at time of inclusion for sFlt-1/PlGF ratio, Follow-up blood test 2 to 4 weeks after inclusion, Placenta analysis for all included patients, even in case of normal birthweight
- Where
- France
- Volunteers
- 167 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Concentration in Neonates With Fetal Growth Restriction
S100B protein is a biomarker that increases following central nervous system (CNS) damage. Measuring this protein's levels may allow for the early identification of infants at high risk for developmental abnormalities, such as…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR)
- Trial name
- NCT06893926
- Testing
- Prenatal ultrasound examination with blood flow analysis, Umbilical cord blood gas analysis, Umbilical cord blood S100B protein level
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Fetal Growth Restriction (FGR)
Melatonin and Perinatal Outcomes in MVM-Related Fetal Growth Restriction (MIMVMFGR)
The goal of this clinical trial is to evaluate the efficacy and safety of melatonin in the treatment of early-onset severe maternal vascular malperfusion-related fetal growth restriction (MVM-FGR), and to determine its effects on…
- Trial name
- MIMVMFGR (NCT07549295)
- Testing
- Melatonin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Fetal Growth Retardation
Sildenafil and Uteroplacental Perfusion
The purpose of this study is to determine whether sildenafil is effective and safe in the treatment of fetal growth restriction.
- Trial name
- NCT01107782
- Testing
- sildenafil
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
GDM, Preterm Preeclampsia
Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study
ASPIRE will be a multi-site, prospective, two-part longitudinal, noninterventional observational cohort study of nulliparous singleton pregnant women to evaluate biomarkers from blood and ocular imaging for prediction of…
- Conditions
- GDM, Preterm Preeclampsia, Preeclampsia, Fetal Growth Restriction (FGR)
- Trial name
- ASPIRE (NCT07669935)
- Testing
- None (this is an observational study with no intervention)
- Where
- 2 sites in United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medicines360
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center