Clinical trials: Fetal Heart Disorder
Trisomy 13, Trisomy 18
Multiple Gestation Study
The objectives of the clinical study are to demonstrate the accuracy of our new NATUS diagnostic method to determine the genetic health of the developing fetuses in a multiple gestation pregnancy from a maternal blood sample.
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
- Trial name
- NCT02278536
- Where
- 8 sites in United States, India and 1 more
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology
This study evaluates maternal psychological distress and the impact of early palliative care team consultation on maternal anxiety and depression symptoms, coping, and quality of life/family functioning in the care of neonates…
- Conditions
- Heart Defects, Congenital, Hypoplastic Left Heart Syndrome, Single Ventricle Defect, Stress, Psychological
- Trial name
- NCT02462434
- Testing
- Early palliative care team consultation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Fetal Membranes, Premature Rupture
Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes
All included patients will have their fetal heart rate recording performed with an EDAN F3 fetal monitor that allowed the back up recording of the fetal heart rate beat to beat detection.
- Trial name
- AiRPM (NCT02901795)
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Congenital Heart Disease
Utility of MRI With Doppler Ultrasound Gating for Advanced Fetal Monitoring
We will test an ultrasound device that uses sound waves to detect the fetal heart beat, and use this device to tell the MRI scanner when to collect pictures of the fetal heart.
- Trial name
- NCT03541291
- Testing
- SMART-SYNC LM03
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Chromosomal Aneuploidies (e.g., Trisomy 21, Trisomy 18, Trisomy 13); Prenatal Screening Accuracy
Evaluation of Fetal Bladder Emptying During the 11-14 Weeks' Ultrasound Examination as a Negative Predictive Marker for Chromosomal Abnormalities
Template-Based Brief Summary (Sağlık Profesyonelleri İçin) Study Title: The Negative Predictive Value of First-Trimester Fetal Bladder "Rapid Emptying" (≤40 minutes and post-void ≤2 mm) for Major Chromosomal Aneuploidies: A…
- Trial name
- NCT07165743
- Testing
- 40-Minute Real-Time First-Trimester Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Fetal Heart Failure (Disorder)
The Relationship Between Fetal Baseline Heart-rate and the Level of Acetyl-choline Esterase in Fetal Blood
Pregnant women between 32-41 weeks' gestation designated for either vaginal birth or cesarean section will be recruited for the study.
- Trial name
- NCT03478267
- Testing
- AChE levels
- Where
- Israel
- Volunteers
- 101 people
- Sponsor
- Rambam Health Care Campus
Myocardial Deformation
Fetal Cardiac Strain Imaging Research
Cardiac disease in children may start early in life and evidence of cardiac disease can be seen during prenatal life. A variety of diseases diagnosed during fetal life can put children at risk for cardiac disease.
- Trial name
- NCT01993264
- Testing
- Fetal Echocardiogram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Fetal Cardiac Disorder
Fetal Cardiac Function Evaluation With aCMQ-Strain Fetal (STRAIN)
To assess whether the aCQM-Strain ultrasound method allows a good analysis of fetal cardiac function. Establish normality parameters and compare it with fetuses with risk factors of cardiac dysfunction.
- Trial name
- STRAIN (NCT03536000)
- Testing
- Fetal echocardiography using the aCMQ-Strain method
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Aortic Coarctation
Electronic Archive of Patients With Diagnosis and Suspected Prenatal Diagnosis of Aortic Coarctation
The purpose of this prosective and retrospective observational study is to analyze the clinical and echocardiographic characteristics of infants with prenatal diagnosis of suspected aortic coarctation (CoAo) in order to identify…
- Trial name
- ACOAP (NCT06759103)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Congenital Heart Disease, Fetal Cardiac Disorder
Fetal Cardiac Magnetic Resonance in Detection of CHD
The aim of this clinical prospective study is to investigate the value of fetal cardiac magnetic resonance imaging using a new Doppler ultrasound based gating method for the detection of congenital heart desease.
- Conditions
- Congenital Heart Disease, Fetal Cardiac Disorder, Heart Defect, Congenital
- Trial name
- NCT05066399
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Cardiovascular Diseases, Heart Diseases
Fetal Growth Restriction & Maternal Cardiovascular Risk
To determine whether or not women with a history of having a baby with intrauterine growth retardation (IUGR) was more likely to have risk factors for cardiovascular disease versus women with a pregnancy not complicated by IUGR.
- Trial name
- NCT00241683
- Volunteers
- 704 people
- Sponsor
- The University of Texas Health Science Center, Houston
Trisomy 21, Trisomy 18
Study of Vanadis® NIPT for Non-invasive Prenatal Screening of Trisomies (T21, T18 and T13)
This study will assess the feasibility of Vanadis NIPT for screening of T21, T18 and T13. The results obtained from Vanadis NIPT will be compared with the study site's current prenatal screening methods.
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- NCT03559374
- Testing
- Vanadis NIPT system
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- PerkinElmer, Wallac Oy
Congenital Heart Disease, Pregnancy Related
Pregnancy in GUCH Patients
This study aims to investigate the impact of congenital heart diseases on maternal and foetal-neonatal health, the effect of pregnancy on maternal cardiac health, and the outcome of newborns/children born from Grown-Up Congenital…
- Conditions
- Congenital Heart Disease, Pregnancy Related, Infant Development, IUGR
- Trial name
- PURE-HEART (NCT06574386)
- Testing
- Neurodevelopmental assessment
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Congenital Heart Disease (CHD), Artificial Intelligence (AI)
A Multicenter Study of Artificial Intelligence Model for Fetal Congenital Heart Disease
This study addresses congenital heart disease in fetuses, a specific birth defect, by collaborating with multicenter medical institutions across China.
- Trial name
- NCT06796127
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Stress, Cortisol; Hypersecretion
Effect of Maternal Cortisol Levels on Fetal Heart Rate Patterns
Objective: This study was designed to determine whether maternal cortisol levels affect fetal heart rate (FHR) patterns at third trimester. Design: Cross-sectional descriptive study.
- Conditions
- Stress, Cortisol; Hypersecretion, Fetal Heart Rate Disorder
- Trial name
- NCT05503433
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Halic University
Attachment, Risk Pregnancy
The Effect of Fetal Heart Sound Played by Parents Diagnosed With Risky Pregnancy on Attachment and Anxiety
The research was designed as a randomized controlled experimental type to determine the effect of fetal heart sound played to parents diagnosed with risky pregnancies on attachment and anxiety.
- Conditions
- Attachment, Risk Pregnancy, Anxiety
- Trial name
- NCT06734754
- Testing
- fetal heart sound listening
- Where
- Turkey (Türkiye)
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Inonu University
Heart Failure With Preserved Ejection Fraction (HFPEF)
Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction
The primary purpose of this study is to evaluate possible association of some heterogeneous circulating biomarkers and anamnestic factors of pregnancy adverse course and outcomes with the prognosis of heart failure with preserved…
- Trial name
- CARPO-HF (NCT06803849)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine