Clinical trials: Fetal Outcomes
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Intrauterine Growth Restriction
Impact of Enoxaparin Therapy on Fetal Outcomes in Intrauterine Growth Restriction
The local literature lacks comprehensive information regarding the actual incidence of intrauterine growth restriction (IUGR) and oligohydramnios and currently available therapeutic options.
- Trial name
- NCT07462182
- Testing
- Enoxaparin, Standard Management
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Muhammad Aamir Latif
Monogenic Diseases, Genetic Diseases, Inborn
Health Economic Evaluation of Non-Invasive Prenatal Exclusion Diagnosis
Since the discovery of a small fraction of circulating cell-free fetal DNA (ccffDNA) in the blood of the mother, non-invasive prenatal diagnosis (NIPD) techniques using a simple blood sample have been developed to 1) screen for…
- Trial name
- PRENATSAFE (NCT07469657)
- Testing
- NIPD by NGS
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Maternal Complications, Pregnancy Complication
Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy
The purpose of this study is to evaluate pregnancy-related health outcomes in participants who are exposed to Epidiolex/Epidyolex during pregnancy and their infant up to 12 months of life.
- Conditions
- Maternal Complications, Pregnancy Complication, Birth Outcomes, Adverse, Pregnancy
- Trial name
- NCT06113237
- Testing
- Epidiolex
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 50 people
- Sponsor
- Jazz Pharmaceuticals
Antenatal Health, Antenatal Care
Healthy Expectancy Through Routine Antenatal STI Screening
This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and…
- Conditions
- Antenatal Health, Antenatal Care, STI, Chlamydia Trachomatis Infection in Pregnancy
- Trial name
- HERA (NCT07458802)
- Testing
- Chlamydia trachomatis and Neisseria gonorrhoeae screening
- Where
- Botswana
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Adriane Wynn
Hypocalcemia, Pregnancy Complications Affecting Fetus (Diagnosis)
Therapeutic Effects of Oat-based Cereal on Fetomaternal Outcomes Among Hypocalcemic Antenatal Women
This study evaluates the therapeutic effects of an oat-based porridge composite on fetomaternal outcomes and calcium/ vitamin D status among hypocalcemic antenatal women.
- Trial name
- NCT07751198
- Testing
- Oat-Based porridge, Calcium & Vitamin D3 supplementation
- Where
- Pakistan
- Volunteers
- 192 people
- Sponsor
- University of Lahore Hospital (ULH)
Prenatal Disorder
Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes
The goal of this study is to ensure that pregnant patients have the resources and support needed to access Prenatal Screening \& Diagnostic Testing (PS\&D) in an informed and evidence-based fashion by developing an innovative…
- Trial name
- OPUS (NCT06382636)
- Testing
- Standard Care, Obstetric Prenatal Genetic Testing Engagement Solution (OPUS) AI Chatbot
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- The Cleveland Clinic
Lactation Disorder - Postpartum Condition or Complication, Nutrition, Healthy
Use of Ritual Epost Postnatal Multivitamins During the Postpartum Period
Multivitamin/multimineral supplements (MVI) provide important nutrition supplement to the diet of pregnant women to cover potential deficiencies and optimize nutrition status of both mom and baby, especially when the diet is…
- Trial name
- NCT05736562
- Testing
- Ritual Epre Multimineral-Vitamin Supplement
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- City University of New York
Gestational Diabetes
Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study
The study is to investigate the impact of blood glucose management at the first trimester of pregnant women with gestational diabetes on the maternal and fetal outcomes and metabolic disorder.
- Trial name
- NCT01833559
- Testing
- Dietary control, Insulin
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Congenital Diaphragmatic Hernia
Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia
The purpose of this study is to evaluate the safety and efficacy of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in cases of severe Congenital Diaphragmatic Hernia (CDH).
- Trial name
- NCT06946576
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion (FETO) Procedure
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Gestational Diabetes Mellitus
Improved Outcomes Associated With Inositol Dietary Supplementation in Women With Gestational Diabetes Mellitus
Objective: Insulin resistance during normal pregnancy and in gestational diabetes mellitus (GDM) are unknown. New criteria are based on fasting glucose levels since the beginning of pregnancy.
- Trial name
- inositol (NCT01342874)
- Testing
- Inositol
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- G. d'Annunzio University
Advanced Maternal Age Pregnancy, Premature
Pregnancies Outcomes in Advanced Maternal Age Women
Pregnancies occurring in advanced maternal age (AMA) have become more common over the last few decades for a variety of reasons.
- Conditions
- Advanced Maternal Age Pregnancy, Premature, Labor Complication, Delivery Complication
- Trial name
- POIAMA (NCT06528340)
- Testing
- spontaneous delivery
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Gestational Diabetes, DUCTUS VENOSUS VOLUME
Placenta, Fetal Liver, Sectional Ductus Venosus Volumes Examined by Three-dimensional Ultrasound in the Second Trimester
Investigators measured the placenta, fetal liver and ductus venosus volumes of pregnant women with GDM diagnosis and normal glycemic indices in the second trimester.Investigators aimed to correlate measurements with…
- Conditions
- Gestational Diabetes, DUCTUS VENOSUS VOLUME, PLACENTA VOLUME, 3D SONOGRAPHY
- Trial name
- NCT06178250
- Testing
- 3D sonography
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Neonatal Abstinence Syndrome
Efficacy and Outcomes of a Non-Pharmacological Intervention for Neonatal Abstinence Syndrome
The purpose of this study is to examine the efficacy of a specially-constructed crib mattress that delivers gentle vibrations (stochastic vibrotactile stimulation) as a complementary, non-pharmacological intervention for treating…
- Trial name
- NCT02801331
- Testing
- Stochastic Vibrotactile Stimulation (SVS)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Elisabeth B Salisbury
Pregnancy Outcome
The 3D Cohort Study (Design, Develop, Discover)
The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children.
- Trial name
- 3D (NCT03113331)
- Where
- Canada
- Volunteers
- 2,366 people
- Sponsor
- Université de Sherbrooke
Pregnancy Disease, Malignancy
Maternal and Fetal Outcomes in Pregnancy With Malignancy
This retrospective study aims to evaluate maternal and fetal outcomes in women diagnosed with malignancy during pregnancy at Assiut University Women's Health Hospital.
- Trial name
- NCT07882329
- Volunteers
- 50 people
- Sponsor
- Assiut University
Severe Intra-uterine Growth Restriction, Preterm Birth
Impact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants
Very early onset intra uterine growth restriction (IUGR) affects 5-10% of pregnancies and is the second leading cause of perinatal mortality.
- Conditions
- Severe Intra-uterine Growth Restriction, Preterm Birth, Neurodevelopmental Disorders, Placental Insufficiency
- Trial name
- NCT05381272
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Congenital Diaphragmatic Hernia, Congenital Abnormalities
Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH
This registry study aims to confirm that FETO increases neonatal survival to discharge and reduces long-term morbidity in fetuses with isolated left CDH and o/e LHR < 30%, or isolated right CDH and o/e LHR ≤ 45%, compared to…
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Abnormalities, Neonatal Diseases and Abnormalities, Hernia, DIaphragmatic, Congenital
- Trial name
- NCT07166172
- Testing
- Fetal Treatment Arm (FETO Group)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Pregnancy Related
Evaluation of Electronic Pregnancy Registers and Mobile Applications for Monitoring Pregnancy Outcomes ( EVAPREAP )
Monitoring pregnancy outcomes during pregnancy is very important in assessing the effectiveness of interventions. This study aims to create pregnancy registers and evaluate pregnancy mobile applications as a potential tool for…
- Trial name
- NCT06225739
- Testing
- Electronic pregnancy register, In-depth interviews and focus group discussions
- Where
- 4 sites in Benin, Burkina Faso and 2 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Diabetes Mellitus Pregnancy
Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy
Background Diabetes mellitus (DM) is a significant contributor to adverse obstetric and perinatal outcome. There is now clear and unequivocal evidence that adverse pregnancy outcomes are strongly linked to maternal hyperglycemia…
- Trial name
- NCT05479214
- Testing
- Metformin, Insulin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University