Clinical trials: Fibrillation, Atrial
Atrial Fibrillation
nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation
To demonstrate safety and effectiveness of nMARQ Catheter System [nMARQ] compared with THERMOCOOL® Navigational Family of catheters in treating subjects with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF).
- Trial name
- NCT01824394
- Testing
- nMARQ Navigation Catheters, NaviStar ThermoCool Catheters
- Volunteers
- 481 people
- Sponsor
- Biosense Webster, Inc.
Cardiovascular Diseases, Atrial Fibrillation
A Digital Flu Intervention for People With Cardiovascular Conditions
A 6-month prospective, digital randomized controlled trial targeting approximately 49,000 individuals to evaluate the effectiveness of an influenza vaccination intervention during influenza season for people with cardiovascular…
- Conditions
- Cardiovascular Diseases, Atrial Fibrillation, Abnormal Heart Rhythms, Cardiac Arrest
- Trial name
- CardioFlu (NCT04584645)
- Testing
- Targeted digital intervention
- Where
- United States
- Volunteers
- 49,138 people
- Sponsor
- Evidation Health
Paroxysmal Atrial Fibrillation
The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation
This is a prospective, adaptive, multi-center, randomized safety and effectiveness pivotal study comparing the FARAPULSE Pulsed Field Ablation System with standard of care ablation with force-sensing RF catheters and cryoballoon…
- Trial name
- ADVENT (NCT04612244)
- Testing
- FARAPULSE Pulsed Field Ablation System, RadioFrequency and Cryoballoon Ablation
- Where
- 34 sites in United States
- Volunteers
- 706 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of HSY244 in Participants With Atrial Fibrillation
This was a randomized, placebo-controlled, investigator- and participant-blinded study to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of HSY244 in participants with atrial fibrillation (AF), with and…
- Trial name
- NCT04582409
- Testing
- HSY244
- Where
- 4 sites in United States, Germany
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Atrial Fibrillation
Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro)
The QDOT-Micro study is a prospective, multi-center, non-randomized, interventional clinical study.
- Trial name
- NCT02944968
- Testing
- THERMOCOOL SMARTTOUCH® SF-5D catheter
- Volunteers
- 51 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
D-dimer Assay for the Exclusion of Intra-atrial Thrombus Risk Before Ablation of Atrial Fibrillation
The purpose of this study is to determine whether D-dimer dosage allow to exclude risk of intraatrial thrombus before performing an ablation of atrial fibrillation
- Trial name
- NCT02199080
- Testing
- D-dimer assay before ablation of atrial fibrillation
- Where
- 37 sites in France
- Volunteers
- 2,506 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Atrial Fibrillation, Behavior
Patient Centered Mobile Health Technology Enabled Atrial Fibrillation Management
The overall objective of this proposal is to evaluate the feasibility of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib management…
- Trial name
- mTECHAFib (NCT05400837)
- Testing
- Corrie Virtual Atrial Fibrillation Management Program
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation
Topera E-FIRM Registry
This is a registry to assess the safety and effectiveness of FIRM guided procedures for the treatment of symptomatic any type of atrial fibrillation.
- Trial name
- NCT02386345
- Where
- 9 sites in Germany, Netherlands
- Volunteers
- 299 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Atrial Fibrillation
Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor.
- Trial name
- RAFT-AF (NCT01420393)
- Testing
- Rhythm control, Rate Control
- Where
- 21 sites in Brazil, Canada and 2 more
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation
Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)
Atrial fibrillation (AF) is the most prevalent, sustained type of irregular heartbeat and affects over 2 million Americans. Post-operative AF, which leads to significant morbidity and a prolonged hospital stay, complicates 20% to…
- Trial name
- NCT00141778
- Testing
- Ramipril, Spironolactone
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- Vanderbilt University
Atrial Fibrillation, Atrial Flutter
iPhone Helping Evaluate Atrial Fibrillation Rhythm Through Technology
Atrial fibrillation (AF), a condition where the top chambers of the heart beat irregularly, is a major health problem. The long-term goal of this project is to use a personal, mobile heart monitor to help patients better…
- Trial name
- iHEART (NCT02731326)
- Testing
- AliveCor, Behavioral Altering Messaging
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Columbia University
Atrial Fibrillation
The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage
This study is an opportunity for Boehringer Ingelheim to collaborate with Humana to conduct comparative safety and effectiveness studies of dabigatran and warfarin using real world data from Humana's health plan operations.
- Trial name
- NCT02061748
- Testing
- Observational
- Where
- United States
- Volunteers
- 38,499 people
- Sponsor
- Boehringer Ingelheim
Atrial Fibrillation
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
The proposed studies will test this hypothesis by randomizing patients with AF to 2-HOBA or placebo 7 days prior to AF ablation to allow 2-HOBA to reach steady-state levels.
- Trial name
- NCT04433091
- Testing
- 2-Hydroxybenzylamine
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Thrombi
Exclusion of Intra-atrial Thrombus Before Catheter Ablation
Atrial fibrillation is the most frequent heart rhythm disorder. Its symptomatic forms, resistant to drug therapy, require invasive management (catheter ablation), which exposes to potentially serious complications including…
- Trial name
- EXTRALUCID (NCT03455673)
- Testing
- ATE score
- Where
- 15 sites in France, Switzerland
- Volunteers
- 3,160 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Atrial Fibrillation
Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation
The purpose of this study is to prospectively follow the next 200 patients who undergo catheter ablation of atrial fibrillation for symptoms and signs of esophageal injury.
- Trial name
- NCT00584922
- Testing
- Endoscopy in group I (all patients)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Oklahoma
Persistent Atrial Fibrillation
RADAR Clinical Trial
This prospective, multicenter, observational study will examine the ability of real time electrogram processing mapping to identify driver domains to target for ablation in persistent AF patients.
- Trial name
- NCT03263702
- Testing
- Computational Mapping Algorithm
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation
RF Power, LSI and Oesophageal Temperature Alerts During AF Ablation (PiLOT-AF Study)
Atrial fibrillation (AF) is a very common abnormal heart rhythm, triggered by rapid electrical activity originating from the pulmonary veins (PVs) that drain blood from the lungs back to the left atrium (LA).
- Trial name
- PiLOT-AF (NCT02619396)
- Testing
- Combination 1 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall, Combination 2 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall, Combination 3 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Oxford University Hospitals NHS Trust
Atrial Fibrillation
Assessing Arrhythmias After Ablation Using Implantable Recorders
The purpose of this study is to determine if continuous monitoring using an implantable loop recorder (ie. a device that is placed just underneath the skin of the chest and monitors the heart rate and rhythm) for a year long…
- Trial name
- ABACUS (NCT01176617)
- Testing
- Reveal XT implantable loop recorder
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Pennsylvania
Sleep Apnea, Atrial Fibrillation
Influence of Sleep Apnea on Risk of Atrial Fibrillation
The Elucidation of the Influence of Sleep Apnea on Risk of Atrial Fibrillation study. The study involves a case control design to investigate the extent to which there is an independent relationship of sleep disordered breathing…
- Trial name
- Safebeat (NCT02576587)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation, Atrial Flutter
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)
The prevention of perioperative atrial fibrillation (AF) and myocardial injury after non-cardiac surgery (MINS) has the potential to reduce mortality, stroke, and hospital stays in patients undergoing major thoracic surgery.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- COP-AF (NCT03310125)
- Testing
- Active Colchicine
- Where
- 46 sites in United States, Austria and 9 more
- Volunteers
- 3,209 people
- Sponsor
- Population Health Research Institute