Clinical trials: Fibrinogen
Socket Preservation
Post Extraction Changes Following Ridge Preservation Using Partially Demineralized Dentin Block Versus Xenograft
The aim of this study is to clinically and radiographically evaluate the dimensional changes of hard tissue after using Partially Demineralized Dentin Block versus Xenograft in the esthetic zone.
- Trial name
- NCT06429540
- Testing
- Partially Demineralized Dentin Block, Xenograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Heart Disease, Periodontitis
Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
- Trial name
- NCT04305171
- Testing
- non-surgical periodontal treatment
- Where
- 3 sites in Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Ductus Arteriosus, Patent
Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels
The aim of this study is to investigate whether there is a relationship between echocardiographic measurements regarding closure of PDA and serum D-Dimer and Fibrinogen levels in premature infants born before 32nd gestational…
- Trial name
- NCT04508036
- Testing
- Withdrawal of blood samples for D-Dimer, Withdrawal of blood samples for Fibrinogen, Echocardiographic Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
End Stage Renal Disease, Coagulopathy
To Compare TEG (Thrombelastography) and Conventional Tests in CKD Patients
Background: Coagulopathy in chronic kidney disease is multifactorial. Both hypocoagulopathy and hypercoaguability are seen. Conventional tests of coagulation (CCTs) end at the formation of thrombin, and do not take into account…
- Trial name
- NCT03275077
- Testing
- Thromboelastography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases
Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery
We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen…
- Trial name
- NCT06144112
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
IGF-1 Deficiency
IGF-1, IGFBP3, ALS Normative Ranges in Healthy Pediatric Spanish Population
To determine the normative ranges of the Insulin-like Growth Factor 1 (IGF-1), Insulin-like growth factor-binding protein 3 (IGFBP-3), Acid-Labile Subunit (ALS) according to age, sex and pubertal stage of a healthy paediatric…
- Trial name
- EDISON (NCT01676090)
- Where
- 9 sites in Spain
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Ipsen
Burn Injury, Major Trauma
Study of Fibrinogen Metabolism During Severe Trauma and Burns
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
- Trial name
- NCT00588796
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- United States Army Institute of Surgical Research
Hepatocellular Carcinoma, Type 2 Diabetes
Role of LncRNA H19 in The Regulation of IGF-1R Expression
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. In Egypt, it is the most common cause of mortality and morbidity-related cancer.
- Conditions
- Hepatocellular Carcinoma, Type 2 Diabetes, Cancer
- Trial name
- NCT04767750
- Testing
- Blood sample collection
- Where
- 2 sites in Egypt
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Cardiovascular Disease
Dark Chocolate and Platelet Function in Humans
Cardiovascular disease is a major cause of mortality worldwide and responsible for one out of three global deaths. A main characteristic of cardiovascular disease is impaired blood flow and formation of blood clots.
- Trial name
- NCT01099150
- Testing
- Dark chocolate enriched in flavan-3-ols and procyanidins, Standard dark chocolate, White chocolate
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Patients with Acute Leukemia
The Prognostic Role of Fibrinogen to Albumin Ratio in Acute Leukemia Patients
The study aim to investigate whether levels of acute phase reactants at diagnosis and after 6 months of follow-up correlate with survival and response to treatment in newly diagnosed acute leukemia.Ultimately, we will evaluate…
- Trial name
- NCT06668948
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1), Polycystic Ovary Syndrome
Hepassocin Levels in Patients With Polycystic Ovary Syndrome
The investigators aimed to investigate hepassocin levels in patients with polycystic ovary syndrome (PCOS). There are 3 groups aged between 18 and 35 years as non-obese healthy women, non-obese women with PCOS, and obese women…
- Conditions
- Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1), Polycystic Ovary Syndrome, Obesity, Insulin Resistance
- Trial name
- NCT04369248
- Testing
- hepassocin
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fatma ketenci gencer
Interaction Between the GH/IGF-I System and the Immune-system
The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons
Observations in patients with growth hormone (GH)-disturbances have suggested that GH/IGF-I might have anti-inflammatory effects.
- Trial name
- NCT00969644
- Testing
- Somatropin, Pegvisomant
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Insulin-Like Growth Factor I, Healthy
The Efficacy and Safety of an Amino Acid Supplement in Adults
The primary objective of this clinical trial is to determine the efficacy of once daily oral AAS use, as compared to placebo, in increasing serum IGF-1 concentrations within adults aged 35-75 years for up to 90 days.
- Trial name
- NCT05599282
- Testing
- Amino Acid Supplement
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- ZandA Technologies, llc
Hypofibrinogenemia, Bleeding
Transfusion of Pathogen Reduced Cryoprecipitated Fibrinogen to Expedite Product Availability in Perioperative Bleeding
The goal of this quality improvement study is to compare pathogen-reduced cryoprecipitate with traditional cryoprecipitate in liver transplant and cardiovascular patients.
- Trial name
- NCT05711524
- Testing
- Traditional Cryoprecipitate, Pathogen-Reduced Cryoprecipitate
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Obstetric Anesthesia Problems, Placenta Accreta
Fibrinogen Concentrate and Placenta Acreta Spectrum
The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS.
- Trial name
- NCT05938062
- Testing
- the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
IGF1 Deficiency
Effect of Maternal BMI and Type of Infants Feeding on IGF-1 in Infant
IGF-I is a mitogenic and antiapoptotic. paracrine growth factor expressed in all fetal organ. and is essential in fetal and neonatal growth, differentiation and development Several lines of evidence suggest that IGF-I levels are…
- Trial name
- NCT03275272
- Testing
- level of IGF-1 in infants
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Cord Injury
Effect of Low-Dose Baclofen Administration on the GH-IGF1 Axis Study
Insulin-like growth factor I (IGF-I) is used as a measure of the body's ability to produce growth hormone. Growth hormone is important for muscle tissue as well as many other tissues in the body.
- Trial name
- NCT00871455
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Fibrinogen Like Protein 1
Cystatin D Fibrinogen Like Protein 1
to detect role of cystatin D and fibrinogen like protein 1 in rheumatoid arthritis asses relationship between disease activity and cystatin D and fibrinogen like protein 1
- Trial name
- NCT05929989
- Testing
- ELISA TEST
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Assiut University