Clinical trials: Fibrinolysis
Massive Pulmonary Embolism
Massive Pulmonary Embolism: Trial of Non-immunogenic Recombinant Staphylokinase VS Alteplase FORPE
Objective: to evaluate the efficacy and safety of the Recombinant Non-immunogenic Staphylokinase with its single bolus administration in comparison with the bolus-infusion administration of the Alteplase in patients with massive…
- Trial name
- NCT04688320
- Testing
- Recombinant nonimmunogenic staphylokinase, Alteplase
- Where
- 23 sites in Russia
- Volunteers
- 310 people
- Sponsor
- Supergene, LLC
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Oxidative Stress, Endothelial Dysfunction
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3
The purpose of the study is to see how two classes of blood pressure medications,angiotensin-converting enzyme inhibitors (Ace inhibitors) and angiotensin receptor blockers (ARBs), differ in their long term effects on certain…
- Trial name
- NCT00878969
- Testing
- valsartan (ARB), ramipril (ACE inhibitor)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Myocardial Infarction
Single Bolus Recombinant Nonimmunogenic Staphylokinase Versus Single Bolus Tenecteplase (Metalyse) in STEMI
The aim of the study is to determine if single-bolus recombinant nonimmunogenic staphylokinase is effective and save thrombolytic agent in patients presenting ST-segment elevation myocardial infarction in comparison to…
- Trial name
- FRIDOM1 (NCT02301910)
- Testing
- Recombinant staphylokinase, Tenecteplase
- Where
- 17 sites in Russia
- Volunteers
- 382 people
- Sponsor
- Supergene, LLC
Pathologic Fibrinolysis
Fibrinolysis Before Cardiopulmonary Bypass?
It is common practice to use antifibrinolytic agents before and during cardiopulmonary bypass. They are not without side effects.
- Trial name
- NCT01981863
- Testing
- Epsilonaminocaproic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Coronary Artery Disease
Effects Contrast on Platelet Activity, Thrombosis and Fibrinolysis in Patients Undergoing Coronary Angiography
The aim of this study is to determine how two different types of iodinated contrast media (CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect specific markers of thrombogenesis and platelet…
- Trial name
- NCT01848899
- Testing
- Iodixanol, Ioxaglate, Bivalirudin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Prehypertension, Hypertension
Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NCT01595516
- Testing
- Nebivolol, Metoprolol, Bradykinin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Impaired Glucose Tolerance
Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis
The purpose of this study is to determine the effect of chronic PDE5 inhibitor therapy on glucose metabolism in persons with prediabetes.
- Trial name
- NCT01409993
- Testing
- Sildenafil, Hyperglycemic clamp, Euglycemic clamp
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University
Coronary Artery Disease, Angiotensin Converting Enzyme
The RAS, Fibrinolysis and Cardiopulmonary Bypass
Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB).1 CPB is associated with significant morbidity including hemodynamic instability, the transfusion of allogenic blood…
- Conditions
- Coronary Artery Disease, Angiotensin Converting Enzyme, Angiotensin Receptor Blockers, Cardiopulmonary Bypass
- Trial name
- NCT00607672
- Testing
- Ramipril, Candesartan
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- Vanderbilt University
Cardiopulmonary Bypass, Inflammation
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB). CPB is associated with significant morbidity including the transfusion of allogenic blood products, inflammation and…
- Conditions
- Cardiopulmonary Bypass, Inflammation, Fibrinolysis, Surgery
- Trial name
- BRAC (NCT00223704)
- Testing
- HOE 140, Aminocaproic Acid
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University
Obesity
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
The purpose of the study is to determine if giving isosorbide,a drug that is used to treat chest pain, affects blood vessel release of an anti-clotting factor.
- Trial name
- NCT00685945
- Testing
- Control (bradykinin), L-NMMA + bradykinin, Isosorbide + L-NMMA + bradykinin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
End Stage Renal Failure on Dialysis, Complication of Hemodialysis
Study of Inflammation and Oxidative Stress in Persons Undergoing Dialysis
Little is known about how some drugs affect inflammation or clotting factors in people receiving hemodialysis. It is not yet known if these drugs help prevent heart damage as they do in people not undergoing hemodialysis or…
- Trial name
- NCT00732069
- Testing
- Ramipril, Valsartan
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University
Acute Ischemic Stroke
Safety of DS-1040b in Acute Ischemic Stroke Patients Treated With Thrombectomy
The aim of this study is to find out if DS-1040b is safe and tolerable in acute ischemic stroke patients with thrombectomy. Four groups will receive different doses of DS-1040b by intravenous infusion for 6 hours.
- Trial name
- NCT03198715
- Testing
- DS1040b
- Where
- 20 sites in Japan
- Volunteers
- 42 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Total Knee Arthroplasty
Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty
One postoperative complication following unilateral or bilateral total knee arthroplasty is thrombosis (blood clot formation). In this prospective, double-blinded randomized controlled clinical trial, researchers are…
- Trial name
- NCT01815918
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Pleural Infection, Empyema
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator…
- Conditions
- Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion
- Trial name
- NCT03468933
- Testing
- tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Ischemic Stroke
Single Bolus Recombinant Nonimmunogenic Staphylokinase (Fortelyzin) and Bolus Infusion Alteplase in Patients With AIS
The aim of the study is to determine if single-bolus recombinant nonimmunogenic staphylokinase is effective and save thrombolytic agent in patients with ischemic stroke in comparison to alteplase.
- Trial name
- NCT03151993
- Testing
- Recombinant staphylokinase, Alteplase
- Where
- 18 sites in Russia
- Volunteers
- 336 people
- Sponsor
- Supergene, LLC
Metabolic Syndrome
Renin Angiotensin Aldosterone System (RAAS) and Fibrinolysis in Humans: ACEi and PE5i
This study will measure the effect of the agent tadalafil on glucose and insulin homeostasis in people with metabolic syndrome in the presence and absence of an ACE inhibitor.
- Trial name
- NCT00750308
- Testing
- Ramipril, Tadalafil
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Acute Deep Venous Thrombosis of the Lower Extremity
Low-Dose Alteplase to Treat Blood Clots in Deep Leg Veins
This study will test the effectiveness of low-dose recombinant tissue plasminogen activator (rtPA, or alteplase) in dissolving blood clots in deep leg veins.
- Trial name
- NCT00082355
- Testing
- Alteplase (Activase, Genentech)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Richard Chang, M.D.
Pulmonary Embolism, Acute Pulmonary Embolism
Submassive and Massive Pulmonary Embolism Treatment With Ultrasound Accelerated Thrombolysis Therapy
The purpose of this study is to determine if the EKOS EkoSonic® Endovascular Device when used in conjunction with recombinant tissue plasminogen activator (t-PA) as a treatment for acute PE will decrease the ratio of right…
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Sub-massive Pulmonary Embolism, Massive Pulmonary Embolism
- Trial name
- SEATTLE II (NCT01513759)
- Testing
- recombinant tissue plasminogen activator, EKOS EkoSonic Endovascular System
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation