Clinical trials: Fibroids, Uterine
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Leiomyoma
Trial of Mifepristone for Fibroids
The purpose of this trial is to determine if low-dose mifepristone benefits women with symptomatic fibroids.
- Trial name
- NCT00133705
- Testing
- Mifepristone, Inert Capsule
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Rochester
General Anesthesia, Prostate Cancer
Binaural Sound for Remimazolam Induction
It is important to decrease the time-to-loss of consciousness and anesthetics dose of remimazolam for general anesthesia induction.
- Conditions
- General Anesthesia, Prostate Cancer, Uterine Myoma
- Trial name
- NCT06099977
- Testing
- Binaural sound
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Gangnam Severance Hospital
Uterine Fibroids, Polyps
HOME Study: Hysteroscopic Office Myomectomy Evaluation
The purpose of this study is to demonstrate safety and effectiveness of the MyoSure Tissue Removal System when used by community gynecologists in an office setting for the treatment of patients with symptomatic intrauterine…
- Trial name
- HOME (NCT01152112)
- Testing
- Myomectomy
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- Hologic, Inc.
Uterine Fibroids (Leiomyoma)
Microwave Ablation of Uterine Fibroids
This prospective observational study aims to evaluate the effectiveness and acceptability of percutaneous or vaginal ultrasound guided microwave ablation for the treatment or symptomatic uterine fibroids.
- Trial name
- MyoMwa (NCT07780019)
- Testing
- microwave ablation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Leiomyoma, Uterine, High-Intensity Focused Ultrasound Ablation
Establishment of a Decision Aid Tool for Asymptomatic Small Leiomyoma and Analysis of Influencing Factors for Clinical Decision-making Using HIFU
With the younger patients diagnosed with asymptomatic leiomyoma, delay in the reproductive age of women, the advancement of medical technology, and the rapid development of treatment methods, there are many choices between…
- Conditions
- Leiomyoma, Uterine, High-Intensity Focused Ultrasound Ablation, Patients Decision Aids
- Trial name
- NCT05500118
- Testing
- Patients Decision Aids
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Maternity & Child Healthcare Hospital
Myoma;Uterus
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy
Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy
- Trial name
- NCT05761418
- Testing
- Dinoprostone, Misoprostol
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Blood Loss, Surgical, Uterine Myoma
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. 100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to…
- Trial name
- NCT05108597
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Leiomyomas
Somatic Stem Cells in Leiomyomas?
The purpose of this study is to identify and characterize the Somatic Stem Cell (SSC) responsible for the formation and growth of leiomyomas using the Side Population method.
- Trial name
- NCT01592903
- Testing
- Laparoscopic myomectomy. Following analysis and proliferation of cells isolated from removed human leiomyoma.
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Igenomix
Uterine Fibroid
MR Elastography Parameters Impact on MR-HIFU Efficacy in Uterine Fibroids
Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) ablation for fibroids is an outpatient approach for controlling symptom with an excellent safety record.
- Trial name
- ELASTUS (NCT04345003)
- Testing
- Myoma elastography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Uterine Fibroid, Ovary Cyst
TWO DİFFERENT ELECTROSURGERY DEVICES AS MONOPOLAR HOOC AND PLASMAKINETIC BIPOLAR SPATULA EFFECTIVENESS DURING COLPOTOMY
WE DECIDED TO COMPARE TWO DIFFERENT ELECTROSURGERY DEVİCES TO PROVIDE COLPOTOMY. ONE OF THEM İS MONOPOLAR HOOC, THE OTHER DEVİCE İS PLASMAKİNETİC BİPOLAR SPATULA.
- Conditions
- Uterine Fibroid, Ovary Cyst, Endometrial Hyperplasia, Cervical Dysplasia
- Trial name
- NCT04191603
- Testing
- MONOPOLAR HOOC, PLASMAKINETIC BIPOLAR SPATULA
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alkü Alanya Education and Research Hospital
Leiomyoma
Vascular Function and Uterine Fibroids
The purpose of this study is to learn how uterine fibroids may be connected to heart disease and high blood pressure. It is not known what causes fibroids, but they frequently occur in women who also have high blood pressure…
- Trial name
- NCT02123069
- Testing
- Brachial artery catheter, Acetylcholine, Nitroprusside
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Gynecologic Disease, Gynecologic Cancer
Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology
GynRAN is an international, multicentre, transversal, diagnostic and non-interventional study carried out in gynecology-obstetrics/gynecological oncology departments that aims to identify a diagnostic signature for gynecological…
- Conditions
- Gynecologic Disease, Gynecologic Cancer, Endometriosis, Ovarian Cancer
- Trial name
- GynRNA (NCT06392997)
- Testing
- Saliva sample
- Where
- 13 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- ZIWIG
Fibroid Uterus, Leiomyoma
Safety of Treatment of Uterine Fibroids With Asoprisnil
The objective of this study is to determine the long-term safety of asoprisnil in women with symptomatic uterine fibroids who completed the 6 month Study C02-037.
- Conditions
- Fibroid Uterus, Leiomyoma, Menorrhagia, Metrorrhagia
- Trial name
- NCT00156208
- Testing
- Asoprisnil
- Volunteers
- 166 people
- Sponsor
- Abbott
Uterine Fibroid, Adenomyosis
Paracervical Block in Laparoscopic Hysterectomy
It remains controversial whether paracervical block should be performed as a powerful strategy for pain relief in total laparoscopic hysterectomy (TLH), because convincing conclusions are difficult to draw because of the…
- Trial name
- PALAPA (NCT03792009)
- Testing
- Paracervical block, 5% bupivacaine, Normal saline
- Where
- 3 sites in South Korea
- Volunteers
- 86 people
- Sponsor
- Kangbuk Samsung Hospital
Uterine Fibroids
Phase III Study of MR-Guided Focused Ultrasound Surgery for the Treatment of Uterine Fibroids Compared to Myomectomy
The aim of the study is to answer the question, whether in patients with symptomatic and medically not sufficiently treatable uterine fibroids (population) the "Magnetic-Resonance-Guided Focused Ultrasound Surgery" short…
- Trial name
- NCT03948789
- Testing
- Magnetic Resonance Imaging-controlled high-focussed ultrasound therapy, Myomectomy (laparoscopic or open surgical)
- Where
- 4 sites in Germany
- Volunteers
- 127 people
- Sponsor
- Krankenhaus Nordwest
Uterine Fibroids, Menorrhagia, Endometriosis
Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy
The purpose of this study is to compare two ways of performing laparoscopic hysterectomy - robotic-assisted vs. conventional laparoscopy.
- Trial name
- NCT00485355
- Testing
- conventional laparoscopic hysterectomy, robotic assisted laparoscopic hysterectomy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Uterine Leiomyoma
Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin
The investigators´aim is to assess whether the progestagen dienogest reduces leiomyoma volume and its associated symptoms to the same extent as gonadotropin releasing hormone (GnRH) analogs or the progestagen desogestrel or…
- Trial name
- NCT01738724
- Testing
- Dienogest, Goserelin, Desogestrel
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo
Uterine Fibroid, Recurrence
Risk Factors and A Prediction Model of Recurrence of Uterine Fibroids
To research risk factors for recurrence of uterine fibroids and build a prediction model of recurrence of uterine fibroids to facilitate the early detection as well as the early intervention for patients who are prone to recur.
- Trial name
- NCT06234670
- Testing
- No intervertion
- Where
- China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang