Clinical trials: Filtering Surgery
Glaucoma
Will Restasis Eye Drops Increase Your Chance of Having a Successful Surgery?
The purpose of this study is to determine whether reducing inflammation of the surface of the eye with topical Restasis after glaucoma surgery will improve surgical outcomes and increase patient comfort.
- Trial name
- NCT00405431
- Testing
- Restasis, Endura (artificial tears)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Wills Eye
Glaucoma
Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery
The objective of this prospective randomised study is to compare the efficacy and safety of ologen CM (Collagen matrix) and Mitomycin-C (MMC) as adjuncts to filtration surgery in uncontrolled treated glaucoma cases, the efficacy…
- Trial name
- MCToCM (NCT01440751)
- Testing
- Use of ologen Collagen Matrix in trabeculectomy (ologen), Use of Mitomycin-C (MMC) in trabeculectomy
- Where
- 8 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aeon Astron Europe B.V.
Covid19, Personal Protective Equipment
Clinical Trial on the Efficacy of Different Masks With and Without a Peripheral Sealing Device, Against Covid-19
A significant number of professionals subjected to high-risk situations have been infected by Covid-19, due to the lack of adequate respiratory protection equipment or poor marginal sealing adjustments.
- Trial name
- NCT05079308
- Testing
- Peripheral sealing device for surgical mask or filtering face piece, IIR Surgical mask with Filtering face piece
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Open Angle Glaucoma, Ocular Hypertension
Efficacy and Safety of the ExPRESS Implant Versus Deep Sclerectomy in Combined Surgery
The Ex-PRESS Glaucoma Filtration Device is a small, non-valved implant that was designed to lower intraocular pressure (IOP) by shunting aqueous humor from the anterior chamber into the subconjunctival space.
- Trial name
- NCT03201354
- Testing
- Filtration surgery with Ex-PRESS, Non penetrating deep sclerectomy, Cataract extraction
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Institut Catala de Retina
Trabeculectomy
Evaluation of Filtering Bleb After Glaucoma Surgery by AS-OCTA
When antihypertensive drugs or laser therapy can not reach the target intraocular pressure, trabeculectomy (TRAB) is still the standard surgical method for glaucoma.
- Trial name
- AS-OCTA (NCT04515017)
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Covid19
Clinical Efficiency of Surgical Masks and Filtering Face-piece 2 Masks
Recent results demonstrated an increased risk of COVID-19 infection among healthcare workers (HCW), particularly when access to personal protective equipment (PPE) was inadequate. (ref).
- Trial name
- NCT04823351
- Testing
- Surgical Mask
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma
Outflow Facility AIT vs Microshunt
The purpose of this study was to asses differences in nycthemeral (24-h) intraocular pressure (IOP) profiles and outflow facilities between patients who have undergone epibulbar microshunt implantation and ab interno…
- Trial name
- NCT05548959
- Testing
- Pneumatonometry after microshunt implantation, Pneumatonometry after ab interno trabeculectomy
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Wuerzburg University Hospital
Filtering Surgery, Trabeculectomy
Ab Interno Gelatin Microstent With MMC vs. Trabeculectomy With MMC: 3 Year Retrospective Cohort Analysis
To compare 3-year post-operative efficacy and safety of standalone ab interno gelatin microstent (Xen45®) versus trabeculectomy.
- Trial name
- LongGVT (NCT05126069)
- Testing
- Ab interno gelatin microstent, Trabeculectomy
- Where
- Canada
- Volunteers
- 242 people
- Sponsor
- Prism Eye Institute
Bleb Vascularity, Conjunctival Scarring
Bleb Vascularity Change After Subconjunctival Injection Bevacizumab
The occurrence of conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery. Vascular endothelial growth factor is thought to be a key role in the formation of conjunctival scar…
- Trial name
- NCT00815594
- Testing
- bevacizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Glaucoma Therapy
Citicoline and Filtration Surgery
Glaucoma is a group of conditions characterised by a progressive loss of retinal ganglion cells (RGCs) and their axons, leading to characteristic changes in the optic nerve head and the retinal nerve fibre layer.
- Trial name
- NCT07567651
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Glaucoma, Ocular Hypertension
Surgical and Refractive Outcomes of Combined Glaucoma Surgery
The aim of the study is to examine surgical and refractive outcomes of glaucoma combined surgery in six months period of follow up
- Conditions
- Glaucoma, Ocular Hypertension, Filtering Surgery
- Trial name
- NCT04335825
- Testing
- phacotrabeculectomy, ExPress antiglaucoma surgery combined with phacoemulsification
- Volunteers
- 81 people
- Sponsor
- Medical University of Bialystok
Surgical Procedure, Unspecified
Reducing the Negative Effects of Surgical Conditions Use of Double Layer Mask Against Electrocautery With Smoke Filter
This study was conducted to determine and compare the effectiveness of the smoke filtering electrocautery device used to reduce the negative effects of surgical smoke and the use of a double layer mask.
- Trial name
- NCT06550492
- Testing
- smoke filtering electrocautery device, double mask
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Glaucoma, Angle-Closure
Study on Ex-PRESS Implantation Combined With Phacoemulsification in Primary Angle-closure Glaucoma
Primary angle-closure glaucoma (PACG) is common, phacotrabeculectomy is associated with a significant risk of complications.The Ex-PRESS shunt was introduced as a modification to trabeculectomy, with the theoretical advantages of…
- Trial name
- PACG (NCT03323138)
- Testing
- Ex-PRESS and phacoemulsification
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wenzhou Medical University
Glaucoma
Subconjunctival Bevacizumab to Prevent Bleb Failure After Glaucoma Filtration Surgery
This study analyzes the safety and efficacy of off-label Subconjunctival Injection of bevacizumab (Avastin) versus 0.02% mitomycin C (MMC) for preventing bleb failure following glaucoma filtration surgery.
- Trial name
- NCT00468429
- Testing
- Subconjunctival Bevacizumab
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Grewal Eye Institute
Glaucoma
Post-Operative Sub-Tenon Kenalog in Glaucoma Filtering Surgery
Determine efficacy of sub tenon kenalog injections for post-operative management of trabeculectomy procedures.
- Trial name
- NCT00238563
- Testing
- Triamcinolone injection, sub-tenon
- Where
- 2 sites in United States
- Sponsor
- Stanford University
Open Angle Glaucoma, Angle Closure Glaucoma
Oculusgen (Ologen) Glaucoma MMC Control in Estonia
To compare the safety and effectiveness between ologen collagen matrix and mitomycin-C (MMC) in glaucoma surgery. The ologen collagen matrix implantation procedure is same as traditional trabeculectomy except implant the ologen…
- Conditions
- Open Angle Glaucoma, Angle Closure Glaucoma, Uveitis Glaucoma, Young Age Glaucoma
- Trial name
- NCT00524758
- Testing
- ologen (oculusgen) collagen matrix, MMC in Trabeculectomy
- Where
- Estonia
- Volunteers
- 20 people
- Sponsor
- Pro Top & Mediking Company Limited
Nerve Fiber Bundle Defect, Optic Nerve Diseases
Changes of the Peripapillary Retinal Nerve Fiber Layer After Filtration Surgery in Glaucoma Patients
At present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma.
- Trial name
- NCT01422525
- Testing
- spectral domain optical coherence tomography
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Eye Hospital, Würzburg
Glaucoma, Filtering Surgery
Long-Term IOP Fluctuation and VF Progression After Triple Procedure
Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for…
- Conditions
- Glaucoma, Filtering Surgery, Intraocular Pressure
- Trial name
- NCT00428740
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Glaucoma
Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma
Refractory glaucoma often requires vision-sparing trabeculectomy. To increase surgical success, adjunctive pharmacotherapy is utilized albeit the risk of adverse events.
- Trial name
- AvastinvsMMC (NCT02901236)
- Testing
- Standard Guarded Trabeculectomy, Mitomycin C, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- Athens Vision Eye Institute
Glaucoma, Trabeculectomy
Ologen (OculusGen)-Glaucoma MMC Control in Pakistan
The purpose of this study is to compare the safety and effectiveness of the ologen (OculusGen) Biodegradable Collagen Matrix Implant and the MMC group in filtration surgery.
- Trial name
- NCT00472810
- Testing
- ologen collagen matrix in glaucoma filtering surgery, MMC in glaucoma filtering surgery
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Pro Top & Mediking Company Limited