Clinical trials: Filtering Surgery
Glaucoma
Fluorouracil Filtering Surgery Study (FFSS)
To determine whether postoperative subconjunctival injections of 5-fluorouracil (5-FU) increase the success rate of filtering surgery in patients at high risk for failure after standard glaucoma filtering surgery.
- Trial name
- NCT00000122
- Testing
- 5-Fluorouracil
- Sponsor
- National Eye Institute (NEI)
Cataract, Age-related Cataract
Association Between Light Spectrum and Survival After Cataract Surgery
This study was a retrospective observational cohort analysis of subjects aged 65 years and older, who underwent bilateral cataract surgery within a single (15 hospital) healthcare system, to determine the association between type…
- Conditions
- Cataract, Age-related Cataract, Circadian Rhythm Disorders, Glaucoma
- Trial name
- NCT04187157
- Testing
- Blue-light filtering intraocular lens, Conventional intraocular lens
- Where
- United States
- Volunteers
- 10,192 people
- Sponsor
- University of Pittsburgh
Glaucoma, Primary Open Angle Glaucoma
Intraoperative 5-fluorouracil Augmentation of Trabeculectomy
5-fluorouracil (5FU) is an antimetabolite that has been demonstrated to have beneficial effects when injected into the subconjunctival space after glaucoma surgery (trabeculectomy).
- Trial name
- MoreFlow (NCT06745856)
- Testing
- 5-fluorouracil
- Volunteers
- 368 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Glaucoma
Using a Type of Blue Dye to Observe Bleb Function During Cataract Surgery
The investigators aim to conduct a prospective clinical pilot study to investigate the use of VisionBlue staining administered during cataract surgery to 20 patients with history of trabeculectomy for glaucoma as a means to…
- Trial name
- NCT02526706
- Testing
- VisionBlue
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wills Eye
Open-angle Glaucoma
Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Trabeculectomy: A Study in Germany
The aim of this prospective randomized study is to investigate the efficacy and safety of trabeculectomy with ologen Collagen Matrix versus trabeculectomy using mitomycin C (MMC) in patients with medically uncontrolled open angle…
- Trial name
- NCT01174420
- Testing
- Use of ologen Collagen Matrix in trabeculectomy, Use of Mitomycin-C in trabeculectomy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Aeon Astron Europe B.V.
Glaucoma
Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy
Prospective randomized study comparing guarded Ex-PRESS to trabeculectomy. Primary outcome: IOP and success (complete success defined as IOP between 5-18 mmHg and 20% reduction from baseline without medication or additional…
- Trial name
- NCT01263561
- Testing
- ExPRESS shunt, trabeculectomy
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Toronto
Open Angle Glaucoma, Pseudo-Exfoliative Glaucoma
Evaluation of OT-135P (IOPtiMateTM) : Beam Manipulating System for CO2 Laser Assisted Non-Penetrating Glaucoma Surgery
The aim of the study is to evaluate the safety and effectiveness of the IOPtiMate (OT-135P) in Laser Assisted Non-Penetrating Glaucoma surgery in Open-Angle and Pseudoexfoliative Glaucoma patients.
- Trial name
- NCT01059162
- Testing
- Laser Assisted Non-penetrating glaucoma surgery
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- IOPtima Ltd.
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Glaucoma
Effectiveness of a Procedure for Previously Failed Glaucoma Surgery
Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years.
- Trial name
- NCT00347789
- Testing
- Glaucoma surgery- Bleb revision
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Face Mask, Longterm Oxygen Therapy
Impact of Surgical Mask, FFP2 Mask and FFP3 Mask (With and Without Exhalation Valve) on Exercise Tolerance and Blood Gas Parameters of Patients With Known Lung Disease and Long-term Oxygen Therapy
The aim of the study is to find out how blood gas parameters change under the use of surgical mask, FFP2 masks and FFP3 masks (with and without exhalation valve) in patients with known lung disease and long-term oxygen therapy.
- Trial name
- FFP-O2 (NCT05931016)
- Testing
- 6-MWT, Spiroergometry
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital Regensburg
Glaucoma
Ologen (OculusGen)-Glaucoma MMC Control Trial in India
The purpose of this study is to compare the safety and effectiveness of the ologen (OculusGen) Biodegradable Collagen Matrix Implant and the MMC group in filtration surgery.
- Trial name
- NCT00449098
- Testing
- OculusGen Biodegradable Collagen Matrix Implant, Trabeculectomy with MMC
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Pro Top & Mediking Company Limited
Open Angle Glaucoma, Pigmentary Glaucoma
Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for…
- Conditions
- Open Angle Glaucoma, Pigmentary Glaucoma, Pseudoexfoliation Glaucoma
- Trial name
- POAG (NCT07228221)
- Testing
- iStent infinite trabecular micro-bypass system model iS3, iDose TR (Travoprost intracameral Implant) 75mcg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonathon Myers
Glaucoma
Study Comparing the Kinetics of Endothelial Cell Loss Associated With the XEN® Implant Versus Traditional Filtering Surgery for Glaucoma
Glaucoma is a blinding optic neuropathy that affects 60 million people worldwide. Of all the types of existing glaucoma, primary open-angle glaucoma is the most common etiology.
- Trial name
- CINEXEN (NCT04781283)
- Testing
- measurement of endothelial cell density by specular microscopy
- Sponsor
- Fondation Hôpital Saint-Joseph
Glaucoma
Lucentis Versus Mitomycin C During Glaucoma Surgery
Does a new add on (or adjunctive) therapy used in glaucoma surgery improve the success of trabeculectomy? Ranibizumab may offer benefit similar to mitomycin C in preventing epi-scleral fibrosis while avoiding the well known…
- Trial name
- NCT00626782
- Testing
- Ranibizumab, Mitomycin (MMC)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wills Eye
Open-Angle Glaucoma, Surgery
Goniocurettage as First Choice of Surgical Treatment in Chronic Open-Angle Glaucoma: Outcomes and Complications
The study has the purpose to evaluate the effectiveness and safety of the goniocurettage as a first choice of surgical treatment for primary open-angle glaucoma (POAG) in patients with good vision.
- Trial name
- GC (NCT01511094)
- Testing
- Goniocurettage
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Federal University of Minas Gerais
Anti-Glaucoma Medications
Preoperative Visual Aids on Glaucoma Surgical Patients
This study aims to evaluate the impact of preoperative visual aids on anxiety and pain management in patients with low educational backgrounds undergoing glaucoma filtration surgery.
- Trial name
- NCT06478095
- Testing
- Visual aids
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Glaucoma
Evaluation of the Efficacy of Selecta Laser Trabeculoplasty in Patients Undergoing Filtering Surgery
Glaucoma is a common, potentially blinding pathology, threatening patients' autonomy and quality of life. The main aim of treatment is to lower intraocular pressure (IOP) in order to slow nerve fiber loss as much as possible…
- Trial name
- SLT (NCT05900063)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Glaucoma
Pilot Study on a New Self Adjustable Glaucoma Drainage Device
A new self-adjustable glaucoma drainage device has been developed. And to test its efficacy and its safety, a pilot study is designed.
- Trial name
- eV-SEN (NCT07480603)
- Testing
- eyeValve
- Where
- Senegal
- Volunteers
- 10 people
- Sponsor
- Rheon Medical SA
to Compare the Effect of Two Types of IOLs, on the Incidence of Cystoid Macular Edema
The Effect of a Blue Light Filtering IOL
To compare the effect on blood retinal barrier disruption 3 and 12 months after implantation of either a blue light filtering intraocular lens(blue-filtering IOL) or an ultraviolet light filtering intraocular lens(UV-filtering…
- Conditions
- to Compare the Effect of Two Types of IOLs, on the Incidence of Cystoid Macular Edema, After Cataract Surgery
- Trial name
- NCT00571831
- Testing
- intraocular lens implantation
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Showa University
Glaucoma
Baerveldt Versus Paul Study
The Baerveldt Versus Paul (BvP) Study is a Registry-based Randomised Controlled Trial, Comparing the Baerveldt Glaucoma Implant (BGI) and the Paul Glaucoma Implant (PGI).
- Trial name
- BvP (NCT07733453)
- Testing
- Baerveldt Glaucoma Implant, Paul Glaucoma Implant
- Where
- 4 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sydney