Clinical trials: First Episode Psychosis (FEP), open to volunteers
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
First Episode Psychosis (FEP), Clinical High Risk for Psychosis (CHR)
Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication
The goal of this project is to investigate whether a systematic screening approach enhanced by an innovative model of communicating information about psychosis and treatment options to patients and families (ComPsych) can reduce…
- Trial name
- EaSIE (NCT05509998)
- Testing
- Screening Method (SM), Screening and Communication Method (SCM)
- Where
- United States
- Volunteers
- 912 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
First Episode Psychosis (FEP)
Enhancing Cognitive and Work/School Outcomes in First Episode Psychosis Using Cognitive Self-Management Strategies
The goal of this pilot cluster randomized trial is to understand if adding a standardized cognitive self-management program, Thinking Skills for Work-Cognitive Self-Management Strategies (CSM) to Coordinated Specialty Care…
- Trial name
- NCT07749105
- Testing
- Thinking Skills for Work-Cognitive Self-Management Program (CSM), Treatment as Usual (TAU)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
First Episode Psychosis (FEP)
California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis
The proposed project seeks to create a California early psychosis network using a core assessment battery of valid, low burden measures and mHealth technology platform to collect client-level data, visualize data via clinician…
- Trial name
- EPI-CAL (NCT04007510)
- Testing
- EPI-CAL data network, Community DUP Assessment Tool
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- University of California, Davis
First Episode Psychosis (FEP), Caregiver Burden
Psychoeducation Program for Family Caregivers Coordinated by an APRN
The aim of this study is to assess the impact of implementing a specific family program coordinated by APRNs, covering the 5 levels of the family care pyramid through a consultation, an individual psychoeducation program and a…
- Conditions
- First Episode Psychosis (FEP), Caregiver Burden, Nurse Practitioners, IMPACT OF A NEW PSYCHOEDUCATION PROGRAM COORDINATED BY AN ADVANCED PRACTICE NURSE ON THE BURDEN OF FAMILY CAREGIVERS OF PATIENTS WITH A FIRST PSYCHOTIC EPISODE
- Trial name
- APIPEP (NCT07041463)
- Testing
- Psychoeducation program coordinated by an APRN, Usual Care
- Where
- 5 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
First Episode Psychosis (FEP)
Digital Heart Rate Variability Biofeedback Intervention for First Episode Psychosis
The objective of the current study is to assess the impact of a five-week digital heart rate variability biofeedback (HRV-B) intervention or music listening on the well-being of first episode psychosis patients.
- Trial name
- NCT07628699
- Testing
- Heart Rate Variability Biofeedback, Music Listening
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
First Episode Psychosis (FEP), Psychosis
Early Psychosis: Investigating Cognition
The project aims to explore changes in brain chemistry in individuals who have recently experienced psychosis. Recent research suggests that chemicals in the brain, specifically one called glutamate, may behave differently in…
- Trial name
- EPIC (NCT07196423)
- Testing
- Transcranial direct current stimulation (tDCS), Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
First Episode Psychosis (FEP)
Dopamine and Insulin in Psychosis
Patients with schizophrenia have a high risk of developing metabolic disorders and current evidence points to an overlap in mechanisms underlying psychiatric symptoms and metabolic disturbances.
- Trial name
- DIPS (NCT07252752)
- Testing
- Intranasal Insulin, Low dose insulin infusion, [11C] (+)-4-propyl-(+)-4-propyl-9-hydroxynaphthoxazine (PHNO)
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Psychosis, Cannabis Use Disorder
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
People suffering from psychosis who use cannabis experience more relapses, long and compulsory admissions, with huge costs to the individual, families and health services.
- Conditions
- Psychosis, Cannabis Use Disorder, First Episode Psychosis (FEP)
- Trial name
- CCP RCT (NCT07245212)
- Testing
- CCP Intervention
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- King's College London
Telomere Length, Exercise
Physical Exercise in Patients With First Psychotic Episode
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers.
- Conditions
- Telomere Length, Exercise, First Episode Psychosis (FEP)
- Trial name
- NCT07207538
- Testing
- Other: Strength physical exercise programme, Other: Normal life
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
First Episode Psychosis (FEP), Metabolic Syndrome X
Nursing Intervention in Weight and Metabolic Syndrome Management in First-episode Psychosis (MetaKOP)
The goal of this clinical trial is to evaluate if a nursing intervention based on the carbohydrate-insulin model can effectively reduce weight and manage the risk of metabolic syndrome (MetS) in individuals with first-episode…
- Trial name
- MetaKOP (NCT06650943)
- Testing
- Nursing Consultation in Weight Management and Metabolic syndrome
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Hospital de Basurto
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne