Clinical trials: First Episode Psychosis (FEP)
Engagement, Patient, First Episode Psychosis
Optimizing Engagement in Services for First-Episode Psychosis
This study will compare a 12-session behavioral activation (BA) intervention modified for first-episode psychosis (FEP) to usual community mental health care (i.e., treatment-as-usual; TAU) delivered over 6 months with a sample…
- Trial name
- NCT05310838
- Testing
- Behavioral Activation for First Episode Psychosis, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- California State University, San Bernardino
First Episode Psychosis (FEP), Caregiver Burden
Psychoeducation Program for Family Caregivers Coordinated by an APRN
The aim of this study is to assess the impact of implementing a specific family program coordinated by APRNs, covering the 5 levels of the family care pyramid through a consultation, an individual psychoeducation program and a…
- Conditions
- First Episode Psychosis (FEP), Caregiver Burden, Nurse Practitioners, IMPACT OF A NEW PSYCHOEDUCATION PROGRAM COORDINATED BY AN ADVANCED PRACTICE NURSE ON THE BURDEN OF FAMILY CAREGIVERS OF PATIENTS WITH A FIRST PSYCHOTIC EPISODE
- Trial name
- APIPEP (NCT07041463)
- Testing
- Psychoeducation program coordinated by an APRN, Usual Care
- Where
- 5 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
First Episode Psychosis (FEP)
Use of Parent Connectors in First Episode Psychosis (FEP)
This study proposes to adapt an evidence based peer parent navigator (PPN) intervention, called Parent Connectors, in which trained and supervised PPNs deliver weekly telephone-based support for six to nine months to parents or…
- Trial name
- NCT04018521
- Testing
- PPN, CSC Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
First-Episode Psychosis
Trial to Increase FEP Attendance
Individuals with first-episode psychosis (FEP) are at high-risk for several poor functional and clinical outcomes, including suicide.
- Trial name
- NCT05967195
- Testing
- Financial Incentive and Text-Messages
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Schizophrenia
Early Medication Discontinuation and Long-term Clinical Outcome in FEP
The study aims to examine the relationship between early maintenance therapy decisions in first episode psychosis, and the subsequent long-term clinical outcome at 9-10 years by comparing a group of patients who were randomized…
- Trial name
- FEP (NCT01926340)
- Where
- Hong Kong
- Volunteers
- 178 people
- Sponsor
- Professor Eric Y.H. Chen
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Caregiver Burden, Cannabis Use
Skills for Talking About Cannabis for Families of Young Adults With Psychosis
The objectives of this research is to (1) create a family intervention and provider manual to train family members of young people with psychosis (YP-P) who are heavy cannabis users new communication skills to motivate change in…
- Conditions
- Caregiver Burden, Cannabis Use, Expressed Emotion, Communications Skills
- Trial name
- STAC (NCT06961877)
- Testing
- Cannabis Conversation Skills for Families (CCSF)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia; Psychosis, Schizo Affective Disorder
Adapted Physical Activity Program for Patients Undergoing Antipsychotic Treatment of a First Episode of Psychosis
The purpose of this PILOT feasibility study is to verify the acceptability, feasibility, and compliance to the DYNAMO-PSY program among young adults treated with antipsychotics for a first episode of psychosis (FEP).
- Conditions
- Schizophrenia; Psychosis, Schizo Affective Disorder, First Episode Psychosis (FEP)
- Trial name
- DYNAMO-PSY (NCT06643871)
- Testing
- Adapted physical activity program involving connected bikes
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Psychosis, Psychological
Psychoeducative Treatment of FEP With Mobile Training. ThinkApp
The aim of the study is to evaluate the effectiveness of an online intervention through a mobile application, specifically designed for adolescents with a First Psychotic Episode (FEP), as a complement to the pharmacological and…
- Conditions
- Psychosis, Psychological, Therapy
- Trial name
- NCT03161249
- Testing
- Experimental group, Control group
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- International University of La Rioja
First Episode Psychosis (FEP), Psychosis
Early Psychosis: Investigating Cognition
The project aims to explore changes in brain chemistry in individuals who have recently experienced psychosis. Recent research suggests that chemicals in the brain, specifically one called glutamate, may behave differently in…
- Trial name
- EPIC (NCT07196423)
- Testing
- Transcranial direct current stimulation (tDCS), Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
First Episode Psychosis (FEP)
California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis
The proposed project seeks to create a California early psychosis network using a core assessment battery of valid, low burden measures and mHealth technology platform to collect client-level data, visualize data via clinician…
- Trial name
- EPI-CAL (NCT04007510)
- Testing
- EPI-CAL data network, Community DUP Assessment Tool
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- University of California, Davis
First Episode Psychosis (FEP)
Dopamine and Insulin in Psychosis
Patients with schizophrenia have a high risk of developing metabolic disorders and current evidence points to an overlap in mechanisms underlying psychiatric symptoms and metabolic disturbances.
- Trial name
- DIPS (NCT07252752)
- Testing
- Intranasal Insulin, Low dose insulin infusion, [11C] (+)-4-propyl-(+)-4-propyl-9-hydroxynaphthoxazine (PHNO)
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Self Harm, First Episode Psychosis
Psychosocial Intervention for Suicidal Ideation in Individuals With FEP: A Feasibility Trial
To check the feasibility and acceptability of Culturally adapted Cognitive Behavioral Therapy for Psychosis (CaCBTp) and Culturally Adapted Manual Assisted Brief Psychological Intervention for Self-harm (CMAP), which we have…
- Trial name
- CMAP-FEP (NCT05728138)
- Testing
- CMAP Plus CBT
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Pakistan Institute of Living and Learning
First Episode Psychosis (FEP), At Risk Mental State (ARMS)
Reducing the Duration of Untreated Psychosis in the United States
The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP).
- Trial name
- NCT03369730
- Where
- 3 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychosis; Episode
A Mobile Application to Improve Case-management and Patient's Functioning in First Episode Psychosis
First Episode Psychosis (FEP) includes perceptual distortions, delusions and cognitive impairment with severe consequences, such as suicidal behaviour.
- Trial name
- PLAN-e-PSY (NCT04657380)
- Testing
- PLAN-e-PSY mobile application, Control Group
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Hôpital le Vinatier
At-risk Mental States, First Episode Psychosis (FEP)
The Influence of Tennis in Early Intervention
This study involves two groups of participants: one participating in an intervention focused on self-esteem-and thus primarily psychological-and the other on self-esteem and tennis-and thus involving physical activity.
- Trial name
- ITIP (NCT07633899)
- Testing
- Tennis ( physical activity), Self-esteem program
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Esquirol
Psychosis
Cognitive Behavior Therapy (CBT) Informed Mobile-Application for First Episode Psychosis
Onset of First Episode Psychosis (FEP) is at a young age and is a critical period influencing the long-term course of the disorder.
- Trial name
- TechCare (NCT05567575)
- Testing
- Cognitive Behavioral Therapy,
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning
Psychosis, Cannabis Use Disorder
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
People suffering from psychosis who use cannabis experience more relapses, long and compulsory admissions, with huge costs to the individual, families and health services.
- Conditions
- Psychosis, Cannabis Use Disorder, First Episode Psychosis (FEP)
- Trial name
- CCP RCT (NCT07245212)
- Testing
- CCP Intervention
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- King's College London
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)