Clinical trials: First Nations
Anxiety Disorder, Depressive Disorder
Feasibility of a Culturally Adapted Emotional-Behavioral Prevention Program for American Indian Children
American Indians (AI) are at greater risk for anxiety and depression early in life. This is concerning given the potential negative effects of these conditions across the lifespan (substance use, suicide).
- Trial name
- NCT05371665
- Testing
- Culturally Adapted Cognitive-Behavioral Prevention and Early Intervention (PEI) Program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Montana State University
Insulin Resistance, Obesity
Financial Incentives to Exercise for Adolescents
Among youth populations, American Indians have the highest prevalence of diabetes in the United States. This study will use exercise as the principal lifestyle modification approach to reduce the risk of diabetes in this…
- Conditions
- Insulin Resistance, Obesity, Sedentary Lifestyle
- Trial name
- MOVE (NCT01848353)
- Testing
- Exercise training
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Haemophilus Influenzae Type B Infection
Immunogenicity of H. Influenzae Type b PRP-OMP Vaccines in American Indian and Alaska Native Children (the HibVax Study)
The main goal of this study is to compare the Haemophilus influenzae type b antibody response in American Indian / Alaska Native (AI/AN) infants to two licensed vaccines: Vaxelis and PedvaxHIB.
- Trial name
- NCT04978818
- Testing
- Vaxelis, PedvaxHIB
- Where
- 5 sites in United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy
MEDI-524 (Motavizumab) for the Prevention of Respiratory Sycytial Virus (RSV) Disease Among Native American Indian Infants in the Southwestern United States
MI-CP117 was a Phase 3, randomized, double-blind, placebo-controlled trial designed to determine if motavizumab is more effective than placebo in reducing RSV hospitalization in otherwise healthy Native American Infants in the…
- Trial name
- NCT00121108
- Testing
- Motavizumab
- Where
- 12 sites in United States
- Volunteers
- 2,127 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Substance Use Disorders
Drum-Assisted Therapy for Native Americans
Drum-Assisted Recovery Therapy for Native Americans (DARTNA) is an R-21 NIH/NCCAM-funded study aimed to complete the development and pilot a new substance abuse treatment protocol utilizing drumming for American Indians/Alaska…
- Trial name
- NCT01356667
- Testing
- DARTNA, Treatment-As-Usual
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Human Immunodeficiency Virus (HIV)
e-HERO: Ending the HIV Epidemic in Rural Oklahoma
The goal of this study is to increase HIV and syphilis testing and linkage to care, increase condom use, and promote PrEP uptake among sexual minority men (SMM) and American Indian (AI) men in rural Oklahoma, a state that is an…
- Trial name
- e-HERO (NCT05664802)
- Testing
- e-HERO: Ending the HIV Epidemic in Rural Oklahoma
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Access to Health Care
Improving Native American Elder Access to and Use of Healthcare
This community-driven study features a mixed-method, participatory design to examine help-seeking behavior and healthcare experiences of American Indian elders in New Mexico, in order to develop and evaluate a tailored…
- Trial name
- NCT03550404
- Testing
- Seasons of Care App
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Early Childhood Caries, Dental Caries
Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project
The purpose of this study is to determine whether a bundled best practices oral health intervention utilizing motivational interviewing versus a didactic maternal and child healthy lifestyle intervention will reduce childrens'…
- Trial name
- NCT04556175
- Testing
- Oral Health, Healthy Lifestyle
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Alcohol Use, Marijuana Use
Motivational Interviewing and Culture for Urban Native American Youth (MICUNAY)
The investigators plan to develop and test a new alcohol and other drug (AOD) intervention for urban AI/AN youth, "Motivational Interviewing and Culture for Urban Native American Youth (MICUNAY)." This intervention integrates…
- Trial name
- MICUNAY (NCT02290938)
- Testing
- MICUNAY, Community Wellness Gathering
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- RAND
Tobacco Use, Tobacco Use Disorder
QuitGuide for American Indians: Aims 2 & 3
Aim 3: To test feasibility, acceptability, and preliminary efficacy of the tailored QuitGuide for smoking cessation among AIs.
- Trial name
- NCT05447156
- Testing
- Tailored QuitGuide app, Standard QuitGuide app
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Smoking Cessation
Smoking Cessation for American Indians
American Indians and Alaska Natives (AI/ANs) have the highest smoking rates of the major racial/ethnic groups in the United States, approaching 40% to 50%.1-3 In addition, this underserved population has very low smoking…
- Trial name
- NCT01106456
- Testing
- All Nations Breath of Life (ANBL), Nontailored program (NT), Pharmacotherapy
- Where
- 2 sites in United States
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Won Choi, PhD, MPH
Diabetes Mellitus, Type 2, Metabolic Syndrome
A Patient-Centered Strategy for Improving Diabetes Prevention in Urban American Indians
The goal of the proposed research is to identify effective patient-centered strategies to prevent diabetes in high-risk populations in real world settings.
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT02266576
- Testing
- Standard DPP, Enhanced DPP
- Where
- 2 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Fluoride Varnish and Oral Health Promotion, Usual Care
Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
An intensive intervention of specially trained paraprofessionals, called community oral health specialists (COHS), administering on a quarterly basis for 2 years fluoride varnish and oral health promotion education, compared to…
- Trial name
- NCT01116739
- Testing
- Fluoride varnish, Oral health education, Dental services delivered by the Indian Health Service.
- Where
- United States
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breast Cancer
Intervention to Promote Breast Cancer Screening Among American Indian Women
Our objectives in this project are to develop and evaluate the feasibility and effectiveness of the Mobile Web App Breast Cancer Screening (wMammogram) intervention that is culturally tailored for AI women residing in rural…
- Trial name
- NCT05530603
- Testing
- Educational mobile app
- Where
- 2 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of South Dakota
Cardiovascular Disorder, Coronary Artery Disease
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
This clinical trial develops and tests a culturally-appropriate educational program (Indigenous SIPin) for reducing sugar-sweetened beverage consumption in men affiliated with Native American athletics communities.
- Conditions
- Cardiovascular Disorder, Coronary Artery Disease, Diabetes Mellitus, Obesity-Related Malignant Neoplasm
- Trial name
- NCT06029517
- Testing
- Education Intervention, Observation of Indigenous SIPin Interventon, Discussion
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Suicide
Circle of Life. Improving Capacity of Swampy Cree Community Members to Recognize People at Risk for Suicide
Primary Hypothesis: Participants in the Applied Suicide Intervention Skills Training (ASIST) gatekeeper training will be significantly more likely to have increased knowledge and preparedness to help people with suicidal ideation…
- Trial name
- NCT01287416
- Testing
- Applied Suicide Intervention Skills Training, Resilience Retreat
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Respiratory; Disorder, Functional, Impaired, Respiratory Infection Other
Wood Smoke Interventions in Native American Populations
A critical need exists for efficient community-based interventions aimed at reduction of environmental exposures relevant to health.
- Trial name
- EldersAIR (NCT02240069)
- Testing
- Education (Tx1), Air Filtration Unit Treatment (Tx2)
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Montana
Suicide, Surveillance
Southwest Hub for American Indian Youth Suicide Prevention Research
1. To use a SMART design to evaluate which of four sequences of New Hope (NH), Elders Resilience (ER) and Case Management (CM) have the greater effects on immediate and longer-term suicidal ideation (primary outcome) and…
- Conditions
- Suicide, Surveillance, Mental Health, Substance Use
- Trial name
- NCT03543865
- Testing
- New Hope (NH), Elders Resilience (ER), Case Management (CM)
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cancer, Breast, Cancer, Colon
Enhancing Cancer Prevention and Control Pathways-Native Health Initiative
There are continued disparities in cancer incidence, mortality, and survival between American Indians (AIs) and Whites on cancers responsive to early screening (i.e., breast, colorectal, and cervical) in the US.
- Conditions
- Cancer, Breast, Cancer, Colon, Cancer, Cervix
- Trial name
- NCT04259762
- Testing
- Aim 8 (INT, Pilot Test): Breast, Colorectal, and Cervical Cancer Screening Cognitive-Behavioral Interventions
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance