Clinical trials: First Pregnancy
Suturing of Rectus Muscle at Cesarean Section
The Effect of Rectus Muscle Re-approximation at Cesarean Delivery on Postoperative Pain
The Effect of Rectus Muscle Re-approximation on Postoperative Pain Among Primigravida Singleton Pregnancies Who Underwent Elective Cesarean Section: A Randomized Prospective Trial.
- Trial name
- NCT05260970
- Testing
- Rectus muscle reapproximation at cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Esophageal Cancer, Pancreas Cancer
First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients
The goal of this clinical trial is to investigate a new type of dendritic cell vaccine in patients with refractory or advanced solid tumors of the esophagus, liver, pancreas and ovaries.
- Conditions
- Esophageal Cancer, Pancreas Cancer, Ovarian Cancer, Liver Cancer
- Trial name
- IL15-TransDC (NCT05964361)
- Testing
- IL15-transpresenting WT1-targeted Dendritic Cell Vaccine
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Polycystic Ovary Syndrome
Minimal Stimulation or Clomiphene Citrate in Treatment of Polycystic Ovary Syndrome
The purpose of this study is to compare and determine the the efficacy of minimal stimulation and clomiphene citrate(CC) as the first-line treatment in infertile women with Polycystic Ovary Syndrome(PCOS).
- Trial name
- NCT01157312
- Testing
- clomiphene citrate +highly purified uFSH, clomiphene citrate
- Where
- Egypt
- Volunteers
- 113 people
- Sponsor
- Mansoura University
Breast Cancer, Prostate Cancer
Evaluation of a New Radiotracer (68Ga-NOTA-AE105) for Diagnosing Aggressive Cancer With Positron Emission Tomography
The primary objective of the study is to test a new radiotracer called 68Ga-NOTA-AE105 for PET imaging of uPAR (urokinase plasminogen activator receptor).
- Conditions
- Breast Cancer, Prostate Cancer, Urinary Bladder Cancer
- Trial name
- uPAR-PET (NCT02437539)
- Testing
- Injection of 68Ga-NOTA-AE105, Positron Emission Tomography scans
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ovarian Cancer
Efficacy and Safety of Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Participants With Platinum-sensitive Ovarian Cancer in First Relapse
This research is being done to find out if Carboplatin and Taxane works better alone or when given with an experimental drug called MORAb-003(farletuzumab) in subjects with first platinum sensitive relapsed ovarian cancer.
- Trial name
- NCT00849667
- Testing
- Farletuzumab, Carboplatin, Taxane
- Where
- 375 sites in United States, Argentina and 28 more
- Volunteers
- 1,100 people
- Sponsor
- Morphotek
Urethral Stricture, Bladder (Urothelial, Transitional Cell) Cancer
The Impact of Age and Sex on Anticipated and Experienced Pain in First-Time Outpatient Flexible Cystoscopy
Cystoscopy is a procedure frequently performed in daily urological practice for the diagnosis of various urological conditions, including bladder tumors, benign prostatic hyperplasia, recurrent cystitis, and urethral strictures.
- Conditions
- Urethral Stricture, Bladder (Urothelial, Transitional Cell) Cancer, Benign Prostate Obstruction (BPO)
- Trial name
- PAINCYST (NCT07375641)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Kayseri Education and Research Hospital
Preterm Birth
Feeding Tube Practices and Colonization of the Preterm Stomach in the First Week of Life
Project summary Rationale Many NICU's replace their feeding tubes once a week or more rarely in order to avoid disturbing the infants.
- Trial name
- NCT02830503
- Testing
- Feeding tube daily replacement
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Gorm Greisen
Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination, To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients
Gestional Trophoblastic Neoplasia Ultrasound Assessment: Titanium Study
Gestational trophoblast diseases are characterized by abnormal proliferation of trophoblastic tissue, which can occur consequent to any pregnancy event.
- Conditions
- Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination, To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients, To Identify Ultrasound Predictors of Resistance to First-line Single Drug Chemotherapy in Low-risk GTN Patients, To Investigate if Machine Learning (ML) Algorithms (Radiomics, Deep Neural Networks (DNN), and Other Machine Learning Algorithms
- Trial name
- TITANIUM (NCT06284980)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pregnancy Related
Access to Sperm Donation for Female Couples and Unmarried Women
The Bioethics Law of August 2, 2021 now authorizes, in addition to heterosexual couples, access to sperm donation for female couples and unmarried women.
- Trial name
- PLEIAD (NCT05552560)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Epithelial Ovarian Cancer
Single-arm, Prospective Clinical Trial of Efficacy and Safety of Daphnetin Capsules Combined With TC Regimen for Targeted Maintenance Therapy After Initial Treatment of Stage III-IV Epithelial Ovarian Cancer (RO/R1)
Imaging evaluation was performed every 3 months (± 7 days) from enrollment, and real-time examination was performed if new lesions were suspected.
- Trial name
- NCT07495397
- Testing
- Daphne Extract Capsules
- Where
- China
- Volunteers
- 98 people
- Sponsor
- The First Hospital of Jilin University
Kidney Stone
Robotic-assisted Percutaneous Access
This is a first-in-man (FIM) study to show feasibility and safety profile of the newly developed robotic device for percutaneous access in PCNL surgery.
- Trial name
- NCT04435132
- Testing
- PCL under fluoroscopy with the aid of the robotic device
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- NDR Medical Technology Pte Ltd
Urothelial Cancer
A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic…
- Trial name
- NCT02603432
- Testing
- Avelumab, Best Supportive Care, Following the planned interim analysis for this study: Avelumab
- Where
- 382 sites in United States, Argentina and 27 more
- Volunteers
- 700 people
- Sponsor
- Pfizer
Endometrial Cancer
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.
- Trial name
- TroFuse-033 (NCT06952504)
- Testing
- Pembrolizumab, Carboplatin, Paclitaxel
- Where
- 268 sites in United States, Argentina and 32 more
- Volunteers
- 1,123 people
- Sponsor
- Merck Sharp & Dohme LLC
Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma
Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery
This randomized phase II trial studies how well pazopanib hydrochloride with or without ascorbic acid work in treating patients with kidney cancer that has spread to other places in the body (metastatic) or cannot be removed by…
- Conditions
- Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT03334409
- Testing
- Ascorbic Acid, Pazopanib Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Academic and Community Cancer Research United
Urethra Stenosis, Urethral Stricture
Multi-stage Urethroplasty with Augmentation Using a Dorsal Graft Inlay Technique Comparing Graft Use in First or Second Stage
The principal aim of this pilot study is to directly compare both approaches and analyze the failure rate after one year of follow-up.
- Trial name
- MAGIC I (NCT04965025)
- Testing
- Multi-stage urethroplasty with graft inlay in first stage, Multi-stage urethroplasty with graft inlay in second stage
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Labour Duration, Primigravida
Valethamate Bromide Versus Hyoscine Butyl Bromide in Reducing Labour Duration Among Primigravida
Labour is a physiological process that enables the natural delivery of fetus, placenta and membranes after the age of viability.
- Trial name
- NCT07474350
- Testing
- Valethamate Bromide, Hyoscine butylbromide, Sterile water
- Where
- Nigeria
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Bladder Hyperactivity
Secondary Bilateral Sacral Nerve Stimulation in Overactive Bladder Patients
Unilateral sacral neuromodulation (SNM) has emerged as a valuable treatment for patient with low urinary tract dysfunction when failure or bad tolerance to anticholinergic treatment for overactive bladder.
- Trial name
- NEUROBIL (NCT01960270)
- Testing
- Device: INTERSTIM II
- Where
- 12 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Renal Cell Carcinoma
Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in First-line Advanced Renal Cell Carcinoma.
To learn if the combination of ciforadenant, ipilimumab, and nivolumab can help to control advanced renal cell carcinoma
- Trial name
- NCT05501054
- Testing
- Ipilimumab, Nivolumab, Ciforadenant
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Abortion in First Trimester
The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy
Medical termination of pregnancy (mTOP) generally involves using either a combined regimen consisting of mifepristone and misoprostol, or a misoprostol-only regimen.
- Trial name
- NCT05341817
- Testing
- Letrozole, Mifepristone
- Where
- Singapore
- Volunteers
- 144 people
- Sponsor
- KK Women's and Children's Hospital
Cervical Cancer, Chronic Myeloproliferative Disorders
Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter
RATIONALE: The use of dalteparin may be able to prevent complications caused by the use of a catheter to supply chemotherapy to cancer patients. It is not yet known if dalteparin is effective in reducing these complications.
- Conditions
- Cervical Cancer, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00006083
- Testing
- Fragmin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
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