Clinical trials: First Pregnancy
Renal Cell Carcinoma
Role of TTV During First-line Immunotherapy Treatment in Patients With Renal Cell Carcinoma
The aim of this project is to descriptively explore the trend of torquetenovirus viral load TTV during therapy with immune checkpoint inhibitor ICI in these patients, to evaluate a possible role of this virus as a biomarker of…
- Trial name
- TTV ccRCC (NCT07018037)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Regina Elena Cancer Institute
Polycystic Ovary Syndrome
Comparison Between Laparoscopic Ovarian Diathermy and Clomiphene Citrate in Women With Anovulatory PCOS
Laparoscopic ovarian diathermy (LOD) is currently offered to infertile women with polycystic ovarian syndrome (PCOS) who fail to conceive on clomiphene citrate (CC).
- Trial name
- NCT00220545
- Testing
- Laparoscopic ovarian diathermy
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Pregnant Women Suspected of COVID-19
Descriptive and Evaluation Study of the Use of Pulmonary Ultrasound in the Initial Management of Pregnant Women in the Context of COVID-19
Cohort prospective study. Objectives : Primary objective: To describe the lung ultrasound lesions in pregnant women in case of suspected or confirmed COVID-19 Secondary objectives: To compare the lung ultrasound lesions with…
- Trial name
- LUSCOVIDPREG (NCT04432805)
- Testing
- Performing of lung ultrasound
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Endometrial Cancer
SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma
The purpose of this study is to evaluate the safety and efficacy of SYD985 in recurrent, advanced or metastatic endometrial cancer.
- Trial name
- NCT04205630
- Testing
- SYD985
- Where
- 36 sites in United States, Poland and 5 more
- Volunteers
- 64 people
- Sponsor
- Byondis B.V.
Ovarian Epithelial Cancer
Cytoreductive Surgery and HIPEC in First or Secondary Platinum-resistant Recurrent Ovarian Epithelial Cancer
With 4,600 new cases in France in 2012, ovarian cancer is the seventh most common cancer in women and the fourth cause of mortality by cancer.
- Trial name
- HIPOVA-01 (NCT03220932)
- Testing
- Cytoreductive surgery combined with HIPEC, Chemotherapy and bevacizumab (CT-BEV)
- Where
- 22 sites in France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
First Pregnancy
The Effect of Prenatal Haptonomy on Anxiety, Distress and Psychological Well-being
Introduction:Anksiyete experienced during prenatal can increase Distress, cause negative perinatal outcomes, and adversely affect the psychological well-being.
- Trial name
- NCT05494840
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Hilal Özbek
Advanced Solid Tumors, Hematologic Neoplasms
A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms
The primary goal of this Phase 1 study is to characterize the safety and tolerability of tebotelimab and establish the maximum tolerated dose (MTD) of tebotelimab in advanced solid tumors, and tebotelimab in combination with…
- Conditions
- Advanced Solid Tumors, Hematologic Neoplasms, Ovarian Cancer, HER2-positive Advanced Solid Tumors
- Trial name
- NCT03219268
- Testing
- tebotelimab 1 mg, tebotelimab 3 mg, tebotelimab 10 mg
- Where
- 40 sites in United States, Australia and 6 more
- Volunteers
- 277 people
- Sponsor
- MacroGenics
Retained Products of Conception Post Abortion
Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products
We speculate that the use of combined oral contraceptives may be a possible solution to promote the management of retained pregnancy products versus expectant management.
- Trial name
- NCT03230825
- Testing
- Oral contraceptive, Expectant management
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Medical Induction of Labor Affecting Fetus
Effect Of Intra-muscular Administration of Dexamethasone in Induction of Labour
ABSTRACT: Objective: To evaluate the efficacy of dexamethasone on labor duration and to establish whether dexamethasone plays a role in shorting the duration interval between initiation of labor induction and beginning of the…
- Trial name
- NCT02508402
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Miscarriage
Vaginal Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
Efficacy of vaginal misoprostol 600 Mg versus 800 Mg in termination of the first trimester missed abortion were assist
- Trial name
- NCT05094375
- Testing
- Vaginal Misoprostol 600 mcg, Vaginal Misoprostol 800 mcg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- hany farouk
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary clinical activity of a single…
- Trial name
- NCT07328581
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T following lymphodepletion
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- iCell Gene Therapeutics
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Bladder Carcinoma
First-line Gemcitabine/Cisplatin +/- Avelumab in Locally Advanced or Metastatic Bladder Carcinoma
This study will assess efficacy (based on response rate) and safety (based on grade ≥ 3 severe adverse effects) of the combination Gemcitabine Cisplatin (GC) + anti-PD-L1 (avelumab) in first-line treatment for locally advanced or…
- Trial name
- GCISAVE (NCT03324282)
- Testing
- Avelumab, GC
- Where
- 13 sites in France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Bordeaux
FIGO Stage III and IV Ovarian Cancer, Fallopian Tube Cancers
CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer
A Phase 1B/2 Study to Investigate the Safety and Efficacy of TORL-1-23 with Chemotherapy Given Before Initial Surgery in Women with Advanced Stage Ovarian Cancer
- Conditions
- FIGO Stage III and IV Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer
- Trial name
- NCT07322094
- Testing
- TORL-1-23 and paclitaxel, TORL-1-23 and carboplatin, TORL-1-23, paclitaxel, and carboplatin
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- TORL Biotherapeutics, LLC
Ovarian Cancer
Real-World Study of Niraparib in First-Line Maintenance Therapy for Advanced Epithelial Ovarian Cancer
1. Study Introduction This non-interventional real-world study enrolls patients with ovarian cancer who receive niraparib as first-line maintenance therapy under routine clinical care.
- Trial name
- NCT07783022
- Testing
- Niraparib (Tablet)
- Where
- China
- Volunteers
- 1,920 people
- Sponsor
- Fudan University
Ovarian Cancer
Individualized Precision Treatment Based on Ovarian Cancer Organoid Model
The research purpose of this study is to use organoid cultured from patients' own ovarian cancer tissues as models, screen potential clinical therapeutic drugs (such as paclitaxel, gemcitabine, etc.) in vitro, formulate…
- Trial name
- NCT05813509
- Testing
- Organoid culture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Postpartum Disorder
Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.
Introduction A common problem in women after childbirth is bleeding (5-8 percent). This is one of the leading causes of maternal death in Thailand.
- Trial name
- NCT03617900
- Testing
- Ginger, Paracetamol
- Where
- Thailand
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Iron Deficiency
Pregnancy Outcome in Women With an Iron Deficiency in the First Trimester
The primary aim of this retrospective, monocentric study with two parallel groups is to investigate pregnancy outcome in women with iron deficiency in the first trimester.
- Trial name
- NCT05262634
- Testing
- Data collection (laboratory and obstetric results)
- Where
- Switzerland
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pregnancy, Skin to Skin Contact
Skin-to Skin Contact on Newborn Temperature
This study will compare standard methods of stabilizing a newborn's temperature after birth with mother-infant skin-to-skin contact for stabilizing newborn temperature.
- Trial name
- NCT02143193
- Testing
- Skin-to-Skin Contact
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Rachel Baker
Body Weight, Health Behavior
Body Weight, Body Composition and Energy Balance Related Behavior During the Transition to Parenthood
Understanding critical periods during which people are at risk to gain weight or display unhealthy changes in energy balance related behaviour, i.e.
- Conditions
- Body Weight, Health Behavior, Pregnancy, First Pregnancy
- Trial name
- TRANSPARENTS (NCT03454958)
- Testing
- Measurements of body composition
- Where
- 4 sites in Belgium
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
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