Clinical trials: Fissure in Ano
Fissure in Ano
The Role of Fitostimoline Proctogel in Symptoms Relief and Healing in Patients Affected by Anal Fissure
Evaluate the effectiveness of fitostimoline proctogel in the anal fissure healing and in the need for invasive interventions (primary endpoints) and in the healing of the fissure (secondary endpoint) using Fitostimoline in…
- Trial name
- NCT04714684
- Testing
- Fitostimoline proctogel, Fitostimoline proctogel + muscle relaxant
- Volunteers
- 100 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Pain, Postoperative
Sitz Bath vs no Sitz Bath in Acute Anal Fissure Treatment
To compare the efficacy of 'sitz bath' and 'no sitz bath' treatment in terms of pain improvement, rate of cure and fissure healing in Acute Anal Fissure.
- Trial name
- NCT05666648
- Testing
- Sitz Bath
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital Quetta
Chronic Anal Fissure
Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure
This randomized controlled trial will compare closed versus open lateral internal sphincterotomy (LIS) under spinal anesthesia in patients with chronic anal fissure.
- Trial name
- LIS-CLOSED Tri (NCT07496216)
- Testing
- Closed Lateral Internal Sphincterotomy, Open Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Services Hospital, Lahore
Anal Fissure
A Novel Method for Chronic Anal Fissure Treatment
Investigators performed a prospective pilot study to test the feasibility and safety of autologous adipose derived regenerative cell (ADRC) transplantation in treatment of anal fissures.
- Trial name
- NCT02628522
- Testing
- ADRCs therapy, Celution, Tulip cannulas
- Volunteers
- 6 people
- Sponsor
- Clinical Centre of Serbia
Chronic Anal Fissure
Low Versus High Dose OnabotulinumtoxinA for Chronic Anal Fissure
This prospective single-center cohort study describes short-term and one-year clinical outcomes of two routine doses of OnabotulinumtoxinA (20 units versus 50 units) for chronic anal fissure refractory to conservative therapy.
- Trial name
- NCT07543315
- Testing
- OnabotulinumtoxinA
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Chronic Anal Fissure
Comparison of Lateral Internal Sphincterotomy Techniques for Chronic Anal Fissure
This prospective randomized controlled trial compares three lateral internal sphincterotomy (LIS) techniques in patients with chronic anal fissure refractory to medical treatment: (1) Spasm-Controlled LIS (serial small…
- Trial name
- SPHINX (NCT07520552)
- Testing
- Spasm-Controlled Lateral Internal Sphincterotomy, Lateral Internal Sphincterotomy up to Fissure Apex, Lateral Internal Sphincterotomy up to Dentate Line
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Hemorrhoids, Anal Fistula
Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
The aim of this single-center prospective observational trial is to study the influence of physical and psychological factors on the intensity of pain syndrome after anorectal interventions and to determine the association…
- Conditions
- Hemorrhoids, Anal Fistula, Anal Fissure, Incontinence
- Trial name
- NCT06049524
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center of Endourology "Endocenter"
Hemorrhoids, Hemorrhoidal Disease
War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ)
This study investigated a new understanding of hemorrhoid formation and evaluated a novel systemic treatment. For 200 years, hemorrhoids were conventionally understood as isolated swollen veins.
- Trial name
- NAJ (NCT07034820)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Nimsai Academia
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Chronic Anal Fissure
Transcutaneous Posterior Tibial Nerve Stimulation for Treatment of Chronic Anal Fissure
Lateral internal sphinterotomy (LIS) is the gold standard against which all treatments are compared with a healing rate over 92%. However, the most serious complication of this procedure is anal incontinence.
- Trial name
- NCT02395809
- Testing
- lateral internal sphincterotomy, TENS
- Volunteers
- 94 people
- Sponsor
- Mansoura University
Anal Fissure Chronic, PRP
Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment.
- Trial name
- NCT04320498
- Testing
- prp injection, Anrecta, sitz bath
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- KTO Karatay University
Anal Fissure Chronic
Ultrasound Assessment After Surgery for Chronic Anal Fissure
Chronic anal fissure is a painful tear in the lining of the anal canal that may not heal with medication or other non-surgical treatments. Lateral internal sphincterotomy (LIS) is a commonly used surgical treatment.
- Trial name
- NCT07809711
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Clínico Universitario de Valencia
Anal Fissure
Monocentric Feasibility Study for a New Medical Device for the Treatment of Anal Fissure With Botulinum Toxin
Monocentric feasibility study for a new device for the treatment of anal fissure with botulinum toxin.
- Trial name
- NCT04173130
- Testing
- Anuscope with needles
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Dieter Hahnloser
Acute Anal Fissure, Anal Pain
Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial
The goal of this clinical trial is to compare the therapeutic efficacy and safety profile of Glyceryl Trinitrate (GTN) and Nifedipine ointments in the treatment of acute anal fissures in adults.
- Conditions
- Acute Anal Fissure, Anal Pain, Anorectal Disorders, Sphincter Spasm
- Trial name
- NCT06859554
- Testing
- Glyceryl Trinitrate (GTN) 0.2% Ointment, Glyceryl Trinitrate (GTN) 0.4% Ointment, Nifedipine 0.2% Ointment
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Hafiz Muhammad Hamza
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Fissure in Ano
Pediatrics Anal Fissures Treatment With Polyethylene Glycol
To evaluate whether effectively treating anal fissure-associated constipation using oral PEG alone can eliminate the inconvenience of add topical agent such as DTZ.
- Trial name
- NCT02419534
- Testing
- Polyethylene glycol, Polyethylene glycol with Diltiazem
- Where
- Saudi Arabia
- Volunteers
- 46 people
- Sponsor
- King Saud University
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Chronic Anal Fissure
Effect of Shock Waves Therapy on Chronic Anal Fissure
the study conducted to assess if there is an effect of Extracorporeal Shock Wave Treatment on anal fissure
- Trial name
- NCT04793347
- Testing
- shock master (shock waves device)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- amr bayoumi salama
Anal Fissure
Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure
The standard treatment of anal fissure in the netherlands (ISDN ointment) is being compared to a relatively new treatment (injection of Botox in the internal anal sphincter).
- Trial name
- NCT00827736
- Testing
- Botox, ISDN ointment
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Hemorrhoid Pain, Haemorrhoid Inflammation
Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease
Aim of the study is to assess the efficacy, safety and tolerability of CONAN® (Proctological Cream, Medical Device, Omikron Italia Srl) on most frequent symptoms in grade 1-2 of haemorrhoidal disease and anal fissures.
- Trial name
- NCT05984641
- Testing
- CONAN® Proctological Cream
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Omikron Italia S.r.l.