Clinical trials: Fistula, open to volunteers
Postoperative Pancreatic Fistula Post-pancreatoduodenectomy
Evaluation of the Perfusion of the Pancreatic Remnant With Indocyanine Green and Its Impact on the Reduction of Pancreatic Fistula After Pancreaticoduodenectomy
Postoperative pancreatic fistula (POPF) is the most common complication following cephalic duodenopancreatectomy (DPC) and is a key determinant of severe postoperative morbidity and mortality.
- Trial name
- INDOPANC (NCT07502053)
- Testing
- No Indocyanine Green, Indocyanine Green
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Anal Fistula, Fistula in Ano
Impact of Preoperative Bowel Preparation on Healing Outcomes in FiLaC
Background: Fistula tract laser closure (FiLaC) has emerged as a sphincter-preserving treatment for anal fistula (AF). However, the optimal role of preoperative bowel preparation (BP) in enhancing postoperative outcomes remains…
- Conditions
- Anal Fistula, Fistula in Ano, Laser, Anal Fistula Surgery
- Trial name
- FiLaC-PREP (NCT07800065)
- Testing
- Bowel preparation before fistula laser closure (FiLaC) surgery
- Volunteers
- 100 people
- Sponsor
- Acibadem Kent Hospital
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Fistula-in-ano
Collagen Paste vs Mucosal Advancement Flap for FIA
The treatment for fistula-in-ano (FIA) remains a challenge to General and Colorectal Surgeons Worldwide. A variety of surgical treatments have been described for high anal fistulas, but none offers the panacea of fistula…
- Trial name
- NCT06386835
- Testing
- Collagen Paste, Mucosal advancement
- Where
- 2 sites in Hong Kong
- Volunteers
- 118 people
- Sponsor
- Chinese University of Hong Kong
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Anal Fistula
Role of Autologous Platelet Rich Plasma(PRP) Injection and Platelet Rich Fibrin Glue(PRFG) Interposition for Treatment of Anal Fistula
To evaluate the autologous platelet rich plasma and platelet rich fibrin glue effect on the treatment of anal fistula To asses role of platelet rich plasma and platelet rich fibrin glue in decreasing recurrence of perianal fistula
- Trial name
- NCT06092398
- Testing
- PRP and PRFG in treatment of anal fistula
- Volunteers
- 60 people
- Sponsor
- Assiut University
Surgical Anesthesia
Intercostobrachial Nerve Block vs Erector Spinae Block for Medial Arm A-V Fistula Surgery
Comparison Between Ultrasound-guided Intercostobrachial Nerve Block with Supraclavicular Block versus Ultrasound -guided Erector Spinae block with Supraclavicular Block for Medial Arm A-V Fistula Surgery
- Trial name
- NCT07814703
- Testing
- intercostobrachial nerve block, ultrasound-guided erector spinae plane block
- Where
- Egypt
- Volunteers
- 158 people
- Sponsor
- Fayoum University Hospital
Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia
Primary Posterior Tracheopexy Prevents Tracheal Collapse
Introduction: Children born with a blind-ending gullet (oesophagus), or Oesophageal Atresia (OA), need to undergo surgical correction in the first week of life.
- Conditions
- Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia, Oesophageal Atresia
- Trial name
- PORTRAIT (NCT06335862)
- Testing
- Randomisation between the PPT- and no-PPT-group, Primary Posterior Tracheopexy, Preoperative tracheobronchoscopy
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Perianal Fistula
Comparing Three Surgical Techniques for the Treatment of Transsphincteric Perianal Fistula: (1) Traditional Fistulotomy (Lay Open), (2) Ligation of the Intersphincteric Tract (LIFT) With Adjunctive Endo Fistula Laser Ablation, and (3) Open LIFT Procedure Followed by LASER
>This randomized clinical trial compares three different surgical techniques for the treatment of transsphincteric perianal fistula: (1) traditional fistulotomy (lay open), (2) ligation of the intersphincteric tract (LIFT) with…
- Trial name
- NCT07236047
- Testing
- fistula lay open, LIFT plus LASER, open LIFT plus LASER
- Volunteers
- 90 people
- Sponsor
- Alexandria University
Arteriovenous Fistula, Arteriovenous Fistula Stenosis
Randomised Clinical Trial Comparing Drug-coated Balloon to Plain Balloon for All Peripheral AVF Stenosis
To compare the access circuit primary patency after Ranger drug-coated balloon angioplasty of arteriovenous fistula (AVF) stenosis with that after conventional balloon angioplasty
- Conditions
- Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Dialysis Access Malfunction
- Trial name
- RANGER (NCT06553443)
- Testing
- Angioplasty of all peripheral AVF stenosis
- Where
- Singapore
- Volunteers
- 94 people
- Sponsor
- Singapore General Hospital
End Stage Kidney Disease (ESRD)
Effect of the Amplifi™ Vein Dilation System on Outflow Vein Dilation and AV Fistula Maturation (AMPLIFI-1)
The AMPLIFI-1 Study is a prospective, multicenter pivotal clinical trial designed to evaluate the safety and effectiveness of the Amplifi™ Vein Dilation System in patients requiring distal arteriovenous fistula (AVF) creation for…
- Trial name
- AMPLIFI-1 (NCT07211035)
- Testing
- The Amplifi System is a temporary extracorporeal blood pump designed to deliver controlled flow through a peripheral vein for 24-72 hours prior to AVF creation., Standard of Care (AVF creation)
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Amplifi Vascular, Inc.
Perianal Fistula Due to Crohn's Disease, Fistula in Ano
Safety of Allogeneic Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) to Treat Perianal Fistulas w/ Crohn's Disease
Objectives: Primary: To demonstrate the safety of allogeneic UC-MSCs administered by injection for complex perianal fistulas in patients with Crohn's disease Secondary: To determine the efficacy of a single/multiple allogeneic…
- Trial name
- NCT05039411
- Testing
- PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem Cells
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- CryoCord Sdn Bhd
Periampullary Cancer, Postoperative Pancreatic Fistula
Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula
The primary objective of this clinical trial is to evaluate whether primary total pancreatectomy with simultaneous islet autotransplantation compared with pancreatic head resection (alone) can reduce perioperative morbidity and…
- Trial name
- XandTX (NCT05843877)
- Testing
- Intraportal transplantation of isolated autologous pancreatic islets after total pancreatectomy, Pancreaticoduodenectomy (classic Whipple or pylorus-preserving)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Technische Universität Dresden
Postoperative Pancreatic Fistula, Distal Pancreatectomy
Prophylactic Abdominal Drainage vs no Drainage After Distal Pancreatectomy
Postoperative pancreatic fistula (POPF) is a major source of morbidity and mortality after pancreatic resection, especially after distal pancreatectomy (PD).
- Conditions
- Postoperative Pancreatic Fistula, Distal Pancreatectomy, Drainage
- Trial name
- PANDREAS (NCT06141044)
- Testing
- Avoid surgical drainage
- Volunteers
- 104 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Arterio-venous Fistula, Intracranial Arteriovenous Malformations
PHIL® Embolic System Pediatric IDE
The purpose of this study is to collect information about how the PHIL® Embolic System works in the treatment of intracranial dural arteriovenous fistulas.
- Trial name
- NCT03731000
- Testing
- PHIL® device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Alejandro Berenstein
Venous Stenosis, Venous Occlusion
WRAP North America
The goal of this observational study is to investigate the safety and efficacy of the WRAPSODY CIE in a real-world North American population.
- Trial name
- NCT06807099
- Testing
- Merit WRAPSODY® Cell Impermeable Endoprosthesis (WRAPSODY CIE)
- Where
- 16 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Merit Medical Systems, Inc.
Pancreatic Cancer
Predicting Pancreatic Fistula After Pancreatic Surgery Using Preoperative Immunity
The goal of this observational study is to develop and validate a preoperative immunological signature for predicting postoperative pancreatic fistula (POPF) in adult patients undergoing pancreatic surgery for pancreatic cancer.
- Trial name
- NCT07827911
- Testing
- blood sampling
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Paoli-Calmettes
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Perianal Fistula
FiLaC and PRGF-Endoret for Multi-recurrent Cryptoglandular Perianal Fistula (PLASMA Pilot Study)
Multi-recurrent cryptoglandular perianal fistula represents a challenging clinical problem with no established surgical solution after repeated failures.
- Trial name
- PLASMA (NCT07810075)
- Testing
- Laser ablation of fistula tract using 1000-µm radial fibre (Biolitec, 1470 nm, 12 W, continuous, 1 mm/s withdrawal). Internal opening closed with Vicryl 2/0 suture in all patients
- Volunteers
- 25 people
- Sponsor
- Complejo Hospitalario Universitario de Santiago
Larynx Carcinoma
The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)
Multicenter, prospective, randomized study aimed at evaluating the difference in risk of PCF after salvage laryngectomy in two groups of patients: one cohort treated with Total Laryngectomy (LT) with primary suture, a second…
- Trial name
- NCT06287034
- Testing
- Primary suture
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Regina Elena Cancer Institute