Clinical trials: Flap Necrosis
Flap Monitoring, Inflammation
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective…
- Conditions
- Flap Monitoring, Inflammation, Thrombosis, Oxidative Stress
- Trial name
- DEXFLAP (NCT06993740)
- Testing
- NaCl 0,9%, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Dharmais National Cancer Center Hospital
Flap Necrosis
Near Infrared Imaging and Flap Necrosis
Skin flaps following mastectomy breast surgery that do not have enough oxygen are at risk for necrosis which can increase wound healing problems, postoperative recovery time and be costly to the hospital systems and affect the…
- Trial name
- NCT03476499
- Testing
- Near Infrared Imaging (NIR) device
- Where
- 2 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Crohn Disease, Fistula
Anal Crohn Fistula Surgery
The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.
- Conditions
- Crohn Disease, Fistula, Anoperineal Fistula, Anal Fistula
- Trial name
- FACC (NCT01388257)
- Testing
- All types of surgery procedures, Simple seton drain removal
- Where
- 15 sites in France
- Volunteers
- 180 people
- Sponsor
- French Society of Coloproctology
Prophylactic Mastectomy
Prophylactic Mastectomy: Prospective Evaluation of the Correlation Between Skin Flap Thickness, Residual Glandular Tissue and Skin Necrosis by Imaging and Clinical Examination
Breast cancer is the most common form of cancer among women. Five to ten percent of all breast cancers are due to hereditary factors, with pathogenic variants in the breast cancer genes BRCA1/2 accounting for 2-5% of all breast…
- Trial name
- NCT05162677
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Umeå University
Flap Necrosis, Flap Ischemia
This Study Aims to Explore the Efficacy of Hyperbaric Oxygen in the Treatment of Flap Ischaemic Necrosis After Breast Cancer Surgery
The expectation of our study was to explore the efficacy of using hyperbaric oxygen to rescue flap ischaemic necrosis after breast cancer surgery.
- Trial name
- NCT06811857
- Testing
- hyperbaric oxygen therapy and povidone-iodine wet compresses, wet compresses of povidone-iodine
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Guangdong Provincial People's Hospital
Nasopharyngeal Carcinoma, Postradiation, Necrosis, Endoscopy Surgery, Conservative Treatment
A Randomized Controlled Clinical Trial of Surgery Versus Conservative Treatment for Mild and Moderate-grade Nasopharyngeal Necrosis
Post radiation nasopharyngeal necrosis is a relatively special radiotherapy sequelae after radiotherapy for nasopharyngeal carcinoma.
- Trial name
- NCT05228093
- Testing
- Curative-intent endoscopic necrectomy followed by reconstruction using the posterior pedicle nasal septum and floor mucoperiosteum flap, Conservative treatment
- Where
- 4 sites in China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Wound Complication
The Risk of Postoperative Wound Complications Following the Use of Negative Pressure Wound Therapy in Patients Undergoing Mastectomy
To evaluate the risk of postoperative wound complications following the use of Avelle negative pressure wound therapy in patients undergoing mastectomy and flap fixation, which might serve as a basis for a randomized controlled…
- Conditions
- Breast Cancer, Wound Complication, Wound Infection, Wound Dehiscence
- Trial name
- ALEX (NCT03942575)
- Testing
- Negative pressure wound therapy
- Where
- Netherlands
- Volunteers
- 162 people
- Sponsor
- Zuyderland Medisch Centrum
Flap Necrosis
Monitoring of the Bone Free Flaps With Microdialysis
Microdialysis is admitted to be reliable by numerous surgeons to monitor flaps. Nevertheless, a few authors reported follow up with microdialysis in bone free flaps, and they all describe the position of the catheter in the…
- Trial name
- MTM2018 (NCT03935139)
- Testing
- glucose measurement, lactacte measurement, pyruvate measurement
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pelvic Cancer, Rectal Cancer
Perineal Flap Reconstruction Following Surgery for Advanced Pelvic Malignancy
Flap reconstruction is utilised increasingly for repair of skin and soft tissue defects following pelvic exenteration. Many methods have been proposed but the outcomes associated with each remain largely unknown and the choice…
- Conditions
- Pelvic Cancer, Rectal Cancer, Flap Disorder, Flap Ischemia
- Trial name
- NCT05074082
- Testing
- Flap reconstruction
- Where
- Ireland
- Volunteers
- 883 people
- Sponsor
- St Vincent's University Hospital, Ireland
Blood Flow, Anastomotic Failure of Flap
Effects of Vasopressor on the Graft Blood Flow in TRAM
The purpose of this pilot study is to investigate whether two major vasopressors (norepinephrine vs. phenylephrine) used for treatment of hypotension during breast reconstruction with free flap transfer surgery have different…
- Conditions
- Blood Flow, Anastomotic Failure of Flap, Flap Necrosis, Flap Ischemia
- Trial name
- NCT05049278
- Testing
- Norepinephrine, Phenylephrine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Brain Edema
Swiss Prospective Autologous Bone Flap Resorption Study
The complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. Especially the incidence of bone flap resorption varies from 0% to about 30%.
- Trial name
- SPARS (NCT02320955)
- Testing
- Reimplantation of cryoconserved bone flap
- Where
- 2 sites in Switzerland
- Volunteers
- 88 people
- Sponsor
- University of Zurich
Breast Cancer, Breast Reconstruction
The Use of Laser-Assisted Indocyanine Green Dye Angiography to Predict Mastectomy Skin Flap Viability
In the investigators previous study of 51 breast reconstructions (32 patients), we compared three different assessments of vascular perfusion of tissue; clinical judgment, fluorescein dye angiography (FDA) and laser-assisted…
- Conditions
- Breast Cancer, Breast Reconstruction, Mastectomy
- Trial name
- ICG (NCT01554267)
- Testing
- Laser-Assisted ICG Dye Angiography (SPY System)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stony Brook University
Soft Tissue Filler Complication, Surgical Flap Ischemia
Randomized Evaluation of Indocyanine Green Fluorescence Angiography-Guided Versus Standard Clinical Perfusion Assessment During Gluteal Permanent Synthetic Filler Removal
This randomized clinical trial will compare indocyanine green fluorescence angiography-guided assessment with standard clinical assessment of gluteal flap perfusion during removal of permanent synthetic fillers.
- Conditions
- Soft Tissue Filler Complication, Surgical Flap Ischemia, Tissue Necrosis
- Trial name
- NCT07808957
- Testing
- Indocyanine Green, Standard Clinical Perfusion Assessment
- Where
- Colombia
- Volunteers
- 300 people
- Sponsor
- Research Inc
Skin Necrosis, Breast Reconstruction
B4P Trial - BLOOM43 for Preconditioning
The goal of this clinical trial is to evaluate the use of the Plexaa preconditioning device (BLOOM43) in patients undergoing reconstructive breast surgery for breast cancer.
- Conditions
- Skin Necrosis, Breast Reconstruction, Breast Surgery
- Trial name
- NCT07340632
- Testing
- BLOOM43
- Volunteers
- 60 people
- Sponsor
- Plexaa Ltd
Breast Cancer
The Effects of Indocyanine Green Angiography (IGA) on Deep Inferior Epigastric Artery Perforator (DIEP) Flap Design and Post-Operative Fat Necrosis
The aim of this study is to prospectively evaluate the effect of intra-operative Indocyanine green angiography (IGA) on both flap design and rate of post-operative fat necrosis in patients undergoing autologous breast…
- Trial name
- SPY (NCT02144961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Mastectomy Flap Necrosis
Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis
Background: Mastectomy flap necrosis (MFN) is a common complication that affects recovery, reconstructive success and aesthetic outcome.
- Trial name
- NCT01608880
- Testing
- nitroglycerin ointment, Polysporin ointment
- Where
- 3 sites in Canada
- Volunteers
- 154 people
- Sponsor
- University of British Columbia
Breast Cancer, Vascularization
Fluorescence Angiography in the Assessment of DIEP Flap Perfusion
It is a single-center, prospective, randomized and controlled study focused in microsurgical autologous breast reconstruction. It involves applying indocyanine green (ICG) angiography for the study of the vascularization of DIEP…
- Conditions
- Breast Cancer, Vascularization, Fat Necrosis
- Trial name
- NCT02759796
- Testing
- Tailoring the flap according to clinical assessment, Tailoring the flap according to ICG Angiography assessment
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Infarction
Space Flap for Cerebral Protection Following Decompressive Hemicraniectomy for Stroke
In this study the investigators want to investigate to what extent the application of an artificial bone flape (space flap) influences the success of a decompressive craniectomy.
- Trial name
- NCT04865757
- Testing
- Space Flap
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Flap Necrosis
Lateral Arm Flap Usage as Pedicle and Free Flap
Abstract Introduction For local reconstruction on upper extremity or as a distant micro vascular flap Lateral arm free flap is an excellent source of tissue with the advantages including short operation time, thin pliable tissue…
- Trial name
- NCT03763383
- Testing
- Lateral Arm Flap
- Where
- Pakistan
- Volunteers
- 21 people
- Sponsor
- Aga Khan University
Skin Flap Necrosis, Perfusion; Complications
Feasibility of the IC-Flow Device for Fluorescent Perfusion Evaluation During Feasibility of the IC-Flow Device
1. Primary Objective: Demonstrate that the IC-Flow Imaging device with Indocyanine Green (ICG) is a feasible technique when visualizing and identifying perfusion of organs when compared to The KARL STORZ VITOM II ICG System…
- Trial name
- IC-Flow (NCT03860493)
- Testing
- Perfusion evaluation with indocyanine green
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic