Clinical trials: Flow-mediated Dilation
Chronic Obstructive Pulmonary Disease
The Effects of Aerobic Exercise Training on Vascular, Cardiac and Cerebral Vascular Function in COPD
The primary cause of chronic obstructive pulmonary disease is smoking, which can lead to inflammation in the lungs and blood vessels that can lead to secondary problems such as blood vessel disease, high blood pressure and heart…
- Trial name
- NCT02875522
- Testing
- Individualized, non-linear aerobic exercise training
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sedentary Lifestyle
Polarized Aerobic Training and Vascular Adaptations in Apparently Healthy Individuals
This randomized controlled trial will investigate the effects of a 6-week polarized aerobic training intervention on vascular and cardiorespiratory function in apparently healthy sedentary adults aged 30-50 years.
- Trial name
- ACT-ON-CHRONIC (NCT07665632)
- Testing
- Polarized Aerobic Training
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Endothelial Function
Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals
The purpose of this study is to assess the impact of acute blueberry polyphenol intake on endothelial function of healthy volunteers.
- Trial name
- BB2 (NCT01829542)
- Testing
- Freeze-dried blueberry powder dissolved in water, Control
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Reading
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Atherosclerosis, Cardiovascular Disease
A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese
The purpose of this study is to determine whether non-invasive atherosclerotic measurements (baPWV, IMT, FMD, CACS, ABI) are valuable predictors for cardiovascular events in elderly.
- Trial name
- NCT01208116
- Testing
- Cardiovascular events
- Where
- China
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Cardiovascular Diseases
Cardiovascular Benefits of Acai Polyphenols in Volunteers at Risk of Metabolic Syndrome
The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers.
- Trial name
- AF1 (NCT02292329)
- Testing
- Acai puree, frozen blended it with banana, Control Macronutrient matched
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
The Vascular and Cognitive Effects of Chronic High-flavanol Intake in Healthy Males
A randomised, placebo-controlled, parallel human dietary intervention trial conducted in 33 healthy males to investigate the vascular and cognitive effects of bi-daily consumption of high-flavanol (epicatechin-rich) milk…
- Trial name
- NCT02789761
- Testing
- High-flavanol milk choocolate, Low-flavanol milk chocolate
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy, Healthy Diet
Comparison of the Effect of Red Wine With Alcohol on Flow-mediated Dilation Versus Red Wine Without Alcohol
Introduction: Cardiovascular diseases (CVDs) are the leading cause of global mortality, despite being preventable. Moderate wine consumption has been associated with one of the preventative approaches due to its benefits on…
- Trial name
- NCT06535620
- Testing
- red wine with alcohol, red wine without alcohol
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia de Santa Catarina
Atherosclerosis, Inflammation
Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity
Abdominal obesity is a major risk factor for heart attack, stroke, peripheral vascular disease, dementia, cancer and Type 2 diabetes.
- Trial name
- SAVORO (NCT02576288)
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Histiocytosis, Langerhans-Cell
Cardiovascular Risk Factors and LCH in Adults
Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and hypopituitarism, conditions associated with increased risk of cardiovascular diseases.
- Trial name
- NCT00483925
- Where
- Greece
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Healthy Subjects
Endothelial Dysfunction Induced by Postprandial Lipemia
Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.
- Trial name
- NCT00660491
- Testing
- exercise training
- Where
- Norway
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Healthy
Efficacy of Brooke Bond Black Tea Extract on Flow Mediated Dilation in Indian Males
This study examines the effect of 1800 mg/day standardized Brooke Bond black tea extract, equivalent to 400 mg flavonoids, on Flow Mediated Dilation in healthy Indian males.
- Trial name
- NCT01561300
- Testing
- Nutrition intervention study with a black tea extract, Nutrition intervention study with a control
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Coronary Artery Disease
Biomarkers for Cardiovascular Disease
Biomarkers for Cardiovascular Disease Summary: This study will examine the function of the lining cells of blood vessels and measure substances in the blood to see how they relate to various blood tests, including new tests under…
- Trial name
- NCT00109018
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Postural Tachycardia Syndrome (POTS)
Effect of Dietary Sodium Intake on Vascular Endothelium
The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet.
- Trial name
- NCT01550315
- Testing
- Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Menopause
Vascular Effect of Tibolone in the Brachial Artery
The interruption of the secretion of sex steroids occurring during menopause, causes a change in vascular pattern at various levels. As a result, several agencies have side effects that interfere with women's health.
- Trial name
- TDILA (NCT01543399)
- Testing
- Tibolone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selmo Geber
Diabetes Mellitus, Type 2
Acute Effects of Aerobic Exercise on Flow Mediated Slowing and Flow Mediated Dilation in Adults With and Without Type 2 Diabetes
The endothelium is a protective lining of cells inside blood vessels. It keeps blood vessels working smoothly by controlling how wide or narrow your blood vessels are and protecting them from damage.
- Trial name
- ARM WRESTLING (NCT06684912)
- Testing
- High-intensity interval exercise, Moderate continuous exercise
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Cystic Fibrosis, Endothelial Dysfunction
Vascular Health and Function in Cystic Fibrosis
The goal of this observational study is to learn whether blood vessel health and function differ between adults aged 40 years or older with cystic fibrosis (CF) who are taking CFTR modulator therapy and healthy adults of the same…
- Conditions
- Cystic Fibrosis, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- CF-VHF (NCT07904325)
- Testing
- Non-invasive vascular, cerebrovascular and autonomic assessment
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Endothelial Dysfunction
Effect of Different Methodologies on Variability of Brachial Artery Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery has been widely used as a non-invasive measure of endothelial function. FMD independently predicts future cardiovascular events and can be readily influenced by pharmacological…
- Trial name
- NCT01899937
- Where
- 4 sites in Italy, Netherlands
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) affects up to 14 million people and is among the top five leading causes of death worldwide.
- Trial name
- COPD-LT (NCT02774226)
- Testing
- Tetrahydrobiopterin (BH4), Antioxidant Cocktail
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Augusta University