Clinical trials: Fluency Disorder
Stuttering
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
This Phase 2a clinical trial is an open-label, single-group, within-subjects pilot study designed to evaluate the safety, feasibility, and preliminary efficacy of psilocybin as a therapeutic intervention for adults with…
- Trial name
- NCT07296328
- Testing
- Psilocybin, Speech therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Major Depressive Disorder Remission, Major Depressive Disorder
Vulnerability Markers for Depression
The current study is a pilot for the GRF project entitled "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS".
- Conditions
- Major Depressive Disorder Remission, Major Depressive Disorder, Healthy
- Trial name
- NCT06402422
- Testing
- Theta-burst stimulation
- Where
- Hong Kong
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Stuttering/ Developmental
The Effect of the Non-invasive Brain Stimulation on the Speech Fluency Enhancement
The aim of this study is to determine the effectiveness of concurrent transcranial direct current stimulation (tDCS) and fluency training in adults with developmental stuttering.
- Trial name
- NCT03990168
- Testing
- Anodal tDCS, fluency intervention/ Delayed Auditory Feedback
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Iran University of Medical Sciences
Unipolar Depression
Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode
The study focuses on the identification of clinical, physiological and morphological markers that could predict the response to antidepressant in elderly suffering from unipolar depressive disorder.
- Trial name
- PREDICTage (NCT03227133)
- Testing
- Neuropsychological evaluations, Psychiatric interview, Cardiovascular risk assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Developmental Stuttering
Effectiveness of Digital Manipulation of Thyroid Cartilage and Fluency Shaping Therapy for the Management of Stuttering in Adult
This study was conducted to determine the effectiveness of digital manipulation of thyroid cartilage for the management of stuttering in adult.There were three groups,Group A received Digital Manipulation of Thyroid cartilage…
- Trial name
- NCT03628755
- Testing
- Digital Manipulation of Thyroid cartilage, Fluency Shaping Therapy, combination Group
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Isra University
Stuttering, Adult
Effects of Altered Auditory Feedback on Speech Fluency
The purpose of the study is to use altered auditory vocal feedback to increase fluency in people who stutter and to examine changes in this effect over the course of a one month period occurring outside the laboratory setting.
- Trial name
- NCT06011837
- Testing
- Altered Auditory Feedback
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts Institute of Technology
Alzheimer's Disease, Aphasia
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD).
- Conditions
- Alzheimer's Disease, Aphasia, Dementia
- Trial name
- NCT00814697
- Testing
- Repetitive Transcranial Magnetic Coil Stimulation (rTMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The New York Memory Services
Childhood-Onset Fluency Disorder
A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)
This study is designed to evaluate the effectiveness of NOE-105 on speech fluency without the known antipsychotic-induced side effects of commonly used treatments for childhood onset fluency disorder (COFD).
- Trial name
- NCT05583955
- Testing
- NOE-105
- Where
- 9 sites in United States, Australia
- Volunteers
- 75 people
- Sponsor
- Noema Pharma AG
Stuttering, Adult
Dopamine and Sensorimotor Function in Stuttering
This study is being done to understand the effect of aripiprazole on adults who stutter. Stuttering is a disorder that affects speech fluency.
- Trial name
- NCT07215884
- Testing
- Aripiprazole 10 MG
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stuttering, Fluency Disorder
Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter
The goal of this study is to find out whether a type of noninvasive brain stimulation can help reduce speech errors, such as repetitions, blocks, and prolongations, in people who stutter.
- Trial name
- NCT07354139
- Testing
- High - Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas at Dallas
Stuttering, Developmental
Non-invasive Brain Stimulation in Adults Who Stutter
Research studies in stuttering have shown that activity patterns in certain brain areas differ in people who stutter compared to people who do not stutter when speaking.
- Trial name
- NCT03437512
- Testing
- Anodal tDCS, Fluency training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Michigan
Stuttering, Adult, Childhood-onset Fluency Disorder
Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).
The primary objective of this study is to evaluate the efficacy and tolerability of ecopipam in reducing stuttering symptoms. It is hypothesized that ecopipam effectively reduces stuttering symptoms as measured on the SSI-IV…
- Conditions
- Stuttering, Adult, Childhood-onset Fluency Disorder, Speech Disorders, Language Disorders
- Trial name
- NCT02909088
- Testing
- Ecopipam 50mg, Ecopipam 100mg
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Gerald Maguire, MD
Parkinson Disease
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function.
- Trial name
- NCT04383665
- Testing
- STN DBS 10Hz, STN DBS 130Hz, STN DBS off
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
Covid19, Neurocognitive Dysfunction
Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors.
Long-term neurocognitive and psychiatric consequences of COVID-19 remain mostly unknown to date. It has been reported that coronaviruses cause direct central nervous system infection (Needham et al. 2020).
- Trial name
- NPQCOVID (NCT05019300)
- Testing
- Exposure: COVID-19 severity
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Apraxia of Speech, Aphasia
Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech
Impaired speech production is a major obstacle to full participation in life roles by stroke survivors with aphasia and apraxia of speech.
- Conditions
- Apraxia of Speech, Aphasia, Cerebrovascular Accident
- Trial name
- NCT02094014
- Testing
- Normal Auditory Feedback, Masked Auditory Feedback, Altered Auditory Feedback
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Parkinson's Disease, Deep Brain Stimulation
The Effect of Electrode Implantation for Deep Brain Stimulation (DBS) on Brain Function Using Single Photon Emission Computed Tomography (SPECT) With Technetium-99m-ethyl Cysteinatedimer (Tc-ECD)
The goal of this study is to explore the effect of subthalamic nucleus (STN)-DBS surgery and stimulation in PD (Parkinson's disease) patients on regional cerebral blood (CBF) flow during cognitive task performance or at rest.
- Trial name
- NCT01037686
- Testing
- Injection of 15mCi of Tc-ECD and scanning by SPECT camera, Semantic verbal fluency task performance, Turning off the stimulator
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Stammering
Modifying Unconscious Tongue Movements in Adults With Developmental Stammer.
This is a pilot randomised controlled trial investigating whether using modification of saccadic eye movements can control lateral unconscious tongue positioning and enhance fluency in adults with a confirmed developmental…
- Trial name
- NCT04310436
- Testing
- Modifying saccades by looking down to naval., Modifying saccades by looking in air.
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute of Technology, Sligo
Stuttering, Fluency Disorders
Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering.
- Conditions
- Stuttering, Fluency Disorders, Speech Disorders
- Trial name
- NCT02288598
- Testing
- Anodal TDCS, Fluency Training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Word Finding Difficulty, Communication Disorders
Intervention for Fluency Difficulty
The focus of the study is to identify children with word-finding difficulty and other speech and communication difficulties such as stuttering, a procedure referred to as screening.
- Trial name
- FIST (NCT04217460)
- Testing
- Intervention for fluency difficulty
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London