Clinical trials: Fluency Disorder
Alzheimer's Disease, Aphasia
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD).
- Conditions
- Alzheimer's Disease, Aphasia, Dementia
- Trial name
- NCT00814697
- Testing
- Repetitive Transcranial Magnetic Coil Stimulation (rTMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The New York Memory Services
Childhood-Onset Fluency Disorder
A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)
This study is designed to evaluate the effectiveness of NOE-105 on speech fluency without the known antipsychotic-induced side effects of commonly used treatments for childhood onset fluency disorder (COFD).
- Trial name
- NCT05583955
- Testing
- NOE-105
- Where
- 9 sites in United States, Australia
- Volunteers
- 75 people
- Sponsor
- Noema Pharma AG
Stuttering, Developmental
Non-invasive Brain Stimulation in Adults Who Stutter
Research studies in stuttering have shown that activity patterns in certain brain areas differ in people who stutter compared to people who do not stutter when speaking.
- Trial name
- NCT03437512
- Testing
- Anodal tDCS, Fluency training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Michigan
Parkinson Disease
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function.
- Trial name
- NCT04383665
- Testing
- STN DBS 10Hz, STN DBS 130Hz, STN DBS off
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
Parkinson's Disease
Evaluation of Intensive Language Therapy
Due to Parkinson's Disease (PD) speech and language (SL) deficits may occur. Further, the literature reports that PD patients, who have not undergone deep brain stimulation (DBS), have deficits regarding voice quality (e.g.
- Trial name
- EILT (NCT02935842)
- Testing
- Specific SL-therapy, Rhythmic Balance-Movement Training (rBMT)
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Aphasia, Apraxia of Speech
Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia
Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works.
- Trial name
- NCT05248295
- Testing
- Unison speech (vs. solo), Metrical timing (vs. conversational)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Stuttering, Adult
Bihemispheric Transcranial Direct Current Stimulation* on Speech Fluency
It will be determined whether bihemispheric stimulation (anodal to the left IFG and cathodal to the right IFG) is used with fluency-facilitating conditions for 5 consecutive days in individuals with stuttering and whether there…
- Trial name
- TDCS (NCT06278233)
- Testing
- Transcranial direct current stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biruni University
Computer + Fluency, Computer Only
Evaluation of a Computerized Opioid Overdose Prevention Program
Unintentional fatal drug overdose (OD) is now the 2nd leading cause of accidental death in the general population. Fatal OD from opioid analgesics specifically has increased over 400% between 1999 and 2008, and nonfatal overdose…
- Conditions
- Computer + Fluency, Computer Only, Treatment as Usual
- Trial name
- NCT02040077
- Testing
- Computer + Fluency, Computer Only, Treatment as Usual
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Childhood-Onset Fluency Disorder (Stuttering)
Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 exploratory study in adult subjects with childhood onset fluency disorder.
- Trial name
- NCT04492956
- Testing
- Ecopipam
- Where
- 9 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emalex Biosciences Inc.
Medication Adherence, Hypertension
Social Norms, Messengers, and Processing Fluency to Increase Hypertension Medication Adherence
Medicare Advantage beneficiaries ages 65-79 and insured by Humana with at least two unique fills of hypertension medication within the 2023 calendar year and adherence level between 60 and 85% will be identified using Humana…
- Trial name
- NCT06066541
- Testing
- Scorecard, Social norms, Messenger effects
- Where
- United States
- Volunteers
- 65,177 people
- Sponsor
- Brigham and Women's Hospital
Autism, ASD
Fronto-temporal tDCS Mproves Fluency & Empathy in ASD Kids
Interventional, prospective, randomized, double-blind, placebo-controlled and parallel assignment study, in which patients with Autism Spectrum Disorder (ASD) are two types of intervention by transcranial random noise stimulation…
- Trial name
- tDCS25112013 (NCT02004236)
- Testing
- tRNS Fronto-temporal cortex, tRNS over fusiform temporal cortex
- Where
- 2 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- Spanish Foundation for Neurometrics Development
Stroke
Dextroamphetamine and tDCS to Improve the Fluency
The proposed study aims to evaluate safety and efficacy of combined dextroamphetamine (Dexedrine) and transcranial direct current stimulation (tDCS) with melodic intonation therapy (MIT) for treatment of aphasia after stroke.
- Trial name
- NCT02514044
- Testing
- Dexedrine, Active tDCS, Speech Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston