Clinical trials: Fluid Management, open to volunteers
Postoperative Complications
Intraoperative Fluid Management Guided by Internal Jugular Vein on Postoperative Complications in Abdominal Surgeries
This study investigates the role of respiratory variation in the internal jugular vein as a tool for intraoperative fluid management during abdominal surgeries under general anesthesia.
- Trial name
- NCT07041021
- Testing
- Respiratory variation of the Internal Jugular Vein (IJV)
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Suez Canal University
Acute Kidney Injury, VExUS
Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness
This study will evaluate the use of the Venous Excess Ultrasound (VExUS) score to guide fluid management in critically ill ICU patients through a prospective, multi-aim design combining observational and randomized components.
- Trial name
- DECONGEST-AKI (NCT07291778)
- Testing
- Fluid Management, No intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Sepsis, Shock
Fluid Management and Individualized Resuscitation in Sepsis
The goal of this clinical trial is to find out if a personalized treatment approach can improve care for people with sepsis in the emergency department (ED).
- Conditions
- Sepsis, Shock, Personalized Medicine, Emergency Medicine
- Trial name
- FLUIDS (NCT07009665)
- Testing
- Personalized SV-guided resuscitation, Standard Care Resuscitation
- Where
- Netherlands
- Volunteers
- 188 people
- Sponsor
- University Medical Center Groningen
Craniosynostosis
Pleth Variability Index Monitoring in Pediatric Craniosynostosis Surgery
This prospective observational study aims to evaluate the role of pleth variability index (PVI) and perfusion index (PI) monitoring in intraoperative hemodynamic control among pediatric patients undergoing craniosynostosis…
- Trial name
- PVI-CRANIO (NCT07657598)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Muzaffer GENCER
Pain Management, Postoperative Pain
PCDD Generation 1 Oral Liquid Acetaminophen Delivery Evaluation
This prospective randomized pilot study evaluates the feasibility, acceptability, and preliminary efficacy of the Patient-Controlled Dispenser and Deactivator (PCDD) Generation 1 system for patient-controlled oral liquid…
- Trial name
- NCT07765238
- Testing
- PCDD Generation 1 system
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs)
PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery
Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications.
- Conditions
- Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs), Fluid Over-load
- Trial name
- PRO STRESS (NCT07627360)
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Suez Canal University
Microcirculatory Diffusion, Microcirculatory Convection Capacity
Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery
The aim of the VeMic study is to explore if venous congestion is linked with microcirculatory impairment in elective cardiac surgery patients in the postoperative ICU stay.
- Conditions
- Microcirculatory Diffusion, Microcirculatory Convection Capacity, Venous Congestion, Postoperative Cardiac Surgery
- Trial name
- VeMic (NCT07052461)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Critical Illness, Fluid Therapy
Intravenous Fluid Practices in Turkish Intensive Care Units (TR-FLUID)
Intravenous (IV) fluids-fluids given directly into a vein-are among the most common treatments used in intensive care units (ICUs).
- Conditions
- Critical Illness, Fluid Therapy, Practices
- Trial name
- NCT07649694
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ondokuz Mayıs University
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Heart Failure, Decompensated Heart Failure
Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure
The goal of this clinical trial is to test whether using Bioimpedance Analysis (BIA) can help manage fluid levels in patients with heart failure who are admitted to the hospital with worsening symptoms.
- Trial name
- BIO-HF (NCT07173426)
- Testing
- Bioimpedance analysis
- Where
- United Kingdom
- Volunteers
- 255 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Kidney Transplant, Fluid Management
Phenotype Guided Vasoactive Medication During Kidney Transplantation
The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels.
- Trial name
- NCT07633600
- Testing
- Phenotype-Guided Vasoactive Management
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Jennifer Cutler
Pancreatic Neoplasm, Pancreas Cancer
MSCAN: ctDNA Methylation as Prognostic and Theranostic Tool for Pancreatic Cancer
Developing a characteristic ctDNA methylation panel for pancreatic ductal adenocarcinoma and establishing an intelligent diagnostic and dynamic monitoring model based on ctDNA methylation.
- Trial name
- NCT07045571
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Cardiac Surgical Procedures, Hemodynamics
Structured Hemodynamic Assessment to Guide Care After Cardiac Surgery
This multicenter pilot randomized controlled trial will evaluate whether providing treating physicians with a structured hemodynamic assessment influences care after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures, Hemodynamics, Fluid Therapy, Acute Kidney Injury
- Trial name
- UTF-in-CVICU (NCT07792707)
- Testing
- Expert Report of a Structured Hemodynamic Assessment, Standard Care (in control arm)
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hypothermia Following Anesthesia, Intraoperative Complications
Goal-Directed Temperature Management During Prolonged Abdominal Surgery
During long operations on the abdomen, patients often get cold. Doctors call this perioperative hypothermia. Even a small drop in body temperature can cause problems, such as more bleeding, wound infection, and a longer stay in…
- Conditions
- Hypothermia Following Anesthesia, Intraoperative Complications, Body Temperature Changes, Anesthesia, General
- Trial name
- NCT07854704
- Testing
- Forced-air warming, Intravenous fluid warming, Unwarmed intravenous fluids
- Where
- Russia
- Volunteers
- 61 people
- Sponsor
- The Leningrad Regional Clinical Hospital
Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial.
- Conditions
- Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint, Anterior Disc Displacement
- Trial name
- LPCGF in TMDs (NCT07075276)
- Testing
- Liquid Phase Concentrated Growth Factor, Conventional arthrocentesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Horus University
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
SCD, Vaso Occlussive Crisis
Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis
Sickle cell disease (SCD) is a prevalent inherited blood disorder characterized by vaso-occlusive crises (VOCs), which lead to severe pain and complications.
- Trial name
- FLASC (NCT07188766)
- Testing
- Sodium Chloride (NaCl) 0.9 %
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 394 people
- Sponsor
- Imam Abdulrahman Bin Faisal University