Clinical trials: Fluid Response
Septic Shock
Comparison Between Using Cardiometry and IVC Collapsibility
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Septic shock, a severe form of sepsis, is characterized by persistent hypotension and cellular/metabolic…
- Trial name
- NCT07411469
- Testing
- Cardiometry
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Influenza
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine,(CAIV-T)
The primary objective of this study was to perform a variety of immunological assays on blood, serum, nasal wash samples, and cells obtained from healthy adult subjects for the purpose of developing assays for application in the…
- Trial name
- NCT00192231
- Testing
- CAIV-T
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Peri-Implantitis, Peri-implant Mucositis
Proteomic Analysis of Newly Restored Single Implants
In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Periodontal Diseases
- Trial name
- NCT06379022
- Testing
- Plaque control
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Septic Shock
Characterizing Perfusion and Congestion Responses to Fluid Loading in Critically Ill Septic Patients
Sepsis is a leading cause of mortality worldwide and a major contributor to deaths in intensive care units. Early hemodynamic resuscitation, particularly fluid loading, is a cornerstone of septic shock management.
- Trial name
- FLUID-IMPACTS (NCT07685002)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV, ICL
Tissue Biopsy and Imaging Studies in HIV-Infected Patients
This study will examine tissue from the tonsils, lymph nodes and large bowel of HIV-infected patients to investigate changes in viral load and certain white blood cells during treatment.
- Conditions
- HIV, ICL, Healthy Volunteers
- Trial name
- NCT00001471
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postoperative Complications
Bioelectrical Response to Preoperative Hydration in Colorectal Surgery
This single-center study will evaluate whether short-term changes in bioelectrical impedance measurements after a standardized preoperative intravenous fluid infusion can help predict complications following elective colon or…
- Trial name
- BIA-HYD-CRC (NCT07823530)
- Testing
- Ionolyte Balanced Isotonic Crystalloid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital of Split
Lung Neoplasms, Tumor Immune Microenvironment
Association of BAL Fluid T-Cell Immune Activity With Tumor PD-L1 Expression and Its Prognostic Value: A Prospective Observational Study
This prospective observational study aims to evaluate whether immune profiles of T-cell subsets in bronchoalveolar lavage fluid can complement tumor PD-L1 expression, assessed by immunohistochemistry in tumor tissue specimens, in…
- Trial name
- NCT07331701
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Orthodontic Tooth Movement
Gingival Crevicular Fluid Cytokine Levels in Response to Orthodontic Forces
The aim of this randomized split-mouth study was to quantify simultaneously 30 analytes including cytokines, chemokines and growth factors in gingival crevicular fluid (GCF) in response to different magnitudes of forces during…
- Trial name
- GCF (NCT03555747)
- Testing
- Canine distalization
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Sepsis
Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring
Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation
- Trial name
- NCT03859726
- Testing
- NIRS, Sublingual microcirculation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xiangya Hospital of Central South University
Lung Cancer
Feasibility of ETCO₂ Changes During Passive Leg Raise for Fluid Management in Lung Surgery
Aim: End tidal carbondioxide pressure (EtCO2) is an indirect indicator of cardiac output (CO) which is monitored in every patient at perioperative setting.
- Trial name
- NCT06855966
- Testing
- 250 ml crystalloid bolus infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University - Cerrahpasa
Pneumonia, Bacteremia
Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion
The purpose of our study is to determine the penetration of continuously infused antibiotics at steady state, mainly Meropenem, Vancomycin, Linezolid, Piperacillin/tazobactam and additionally cefepim and ceftazidim, into…
- Trial name
- NCT00435305
- Testing
- Meropenem, Vancomycin, Linezolid
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Healthy Subjects (HS)
Effects of Foam Rolling, Foam Rolling with Dynamic Movement, and Static Stretching on Plantar Flexor Range of Motion and Tissue Properties in Healthy Participants
Each voluntary participant will be invited and tested at the Functional Assessment Laboratory. After reading and completing the informed consent document regarding our research and data processing, participants will be invited…
- Trial name
- NCT06877832
- Testing
- Static Stretching (SS), Foam Rolling (FR), Foam rolling with dynamic movement (FR-DM)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ewan Thomas
Diarrhea Predominant Irritable Bowel Syndrome
Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile Acids
The investigators' hypothesis is that therapy with Colesevelam, reduces fecal bile acid excretion in patients with Irritable Bowel Syndrome (IBS)-diarrhea with prior evidence of increased fecal 48 hour total bile acid excretion.
- Trial name
- NCT02111603
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Hemodynamic Instability
Hemodynamic Response During Goal Directed Fluid Therapy in the OR
The purpose of this study is to retrospectively evaluate the hemodynamic response to goal directed fluid therapy fluid during open abdominal surgery where goal directed fluid therapy is a standard of care after establishing a…
- Trial name
- NCT02365688
- Testing
- Initial bolus pre-incision
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medtronic - MITG
Knee Osteoarthritis
Pilot Synovial Fluid Molecular/Stem Cell Response to PRP in Knee Osteoarthritis: Clinical & Imaging Outcome Correlation
The purpose of this study is to evaluate the affect that platelet rich plasma has on the molecular an cellular functioning of the knee joint.
- Trial name
- NCT02468492
- Testing
- Platelet Rich Plasma, Normal Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Sepsis, Septic Shock
Fluid Resuscitation in Septic Shock Patients With BMI Elevation
To explore the safety and feasibility of alternative fluid resuscitation strategies in obese patients with septic shock.
- Conditions
- Sepsis, Septic Shock, Obesity
- Trial name
- FRISSBE (NCT04759989)
- Testing
- Actual Body Weight Dosing, Adjusted Body Weight Dosing, Ideal Body Weight Dosing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Septic Shock
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume induced by a rapid fluid…
- Trial name
- AUSTRALIS (NCT04693923)
- Testing
- Fluid challenge
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Lymphoma, Large B-Cell, Diffuse
Non-invasive Tumor Immunoglobulin Gene Next Generation Sequencing (IgNGS) in Diffuse Large B Cell Lymphoma (DLBCL)
This study will evaluate IgNGS at different time points in newly diagnosed DLBCL patients homogeneously treated (RCHOP) to address its correlation with conventional techniques (i.e., positron emission tomography/computed…
- Trial name
- NCT04237168
- Testing
- IgNGS from circulating tumor DNA
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sepsis, Acute Respiratory Distress Syndrome
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)
1. Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) 2. Research center: Single-center study. 3.
- Trial name
- NCT04552821
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tianjin Nankai Hospital