Clinical trials: Fluid Response
Sepsis, Septic Shock
Fluids in Septic Shock (FISSH)
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT03677102)
- Testing
- higher chloride crystalloid, lower chloride crystalloid
- Where
- 30 sites in Canada, Saudi Arabia
- Volunteers
- 1,113 people
- Sponsor
- McMaster University
Critical Illness, Sepsis
Role of Active Deresuscitation After Resuscitation-2
RADAR-2 will be a randomised, open-label, allocation concealed, pilot trial of conservative fluid administration and deresuscitation compared with usual care in patients who are critically ill.
- Conditions
- Critical Illness, Sepsis, Trauma
- Trial name
- RADAR-2 (NCT03512392)
- Testing
- Conservative fluid and deresuscitation strategy, Usual care strategy
- Where
- 8 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- Belfast Health and Social Care Trust
Glucose Response
Palm And Rice Bran Oil Study
The objective of the present study is to compare the effects of liquid or solid state of food on glycaemia, lipaemia and insulinaemia.
- Trial name
- PARBO (NCT02969057)
- Testing
- Breakfast with rice bran oil gel, Breakfast with rice bran oil, Breakfast with palm oil gel
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Anesthesia
Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient?
To predict fluid responsiveness in anesthetized pediatric patient is not an easy task although anesthesia provider has to deal with this question on their daily practices.
- Trial name
- PEDIFLUID (NCT02894996)
- Testing
- fluid challenge
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Intraoperative Hemodyamic Monitoring
Arterial dP/dt Dependency on Loading Conditions
In the present study the investigators aim to assess the changes of the arterial dP/dtmax induced by fluids and vasoactive drugs during abdominal surgery
- Trial name
- REABILITY (NCT06164405)
- Testing
- arterial dp/dtmax
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metastatic Breast Cancer
Using a Blood Test to Monitor Metastatic Breast Cancer Treatment
The goal of this observational study is to assess the effectiveness of the mDETECT breast cancer blood test at monitoring treatment response in women with metastatic breast cancer undergoing treatment.
- Trial name
- BEACON (NCT05804578)
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Dr. Christopher Mueller
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Septic Shock
High MAP in Septic Shock With Hypertension
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
- Trial name
- NCT01443494
- Testing
- NE
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Sepsis
Minimal Volume for a Fluid Challenge in Septic Patients
The administration of fluids intravenously is the first step in the stabilization of patients in septic shock. It is important to give the right dose of fluids, enough to improve the function of the cardiovascular system but not…
- Trial name
- NCT02447042
- Testing
- Fluid challenge with crystalloids, Measurement of Pmsf-arm
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- St George's, University of London
Cardiopulmonary Bypass Surgery, Aortic Valve Surgery
Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass
Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Conditions
- Cardiopulmonary Bypass Surgery, Aortic Valve Surgery, Mitral Valve Surgery, Myocardial Revascularization Surgery With Extracorporeal Circulation
- Trial name
- NCT07212842
- Testing
- Methylene Blue, Conventional ultrafiltration, Zero-balance ultrafiltration
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo
Venous Congestion, Microcirculation
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
- Conditions
- Venous Congestion, Microcirculation, Volume Expansion
- Trial name
- MICRO-CONGEST (NCT07499401)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Sepsis, Septic Shock
Fluids in Sepsis and Septic Shock
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT02748382)
- Testing
- higher chloride crystalloid, higher chloride albumin, lower chloride crystalloid
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Hypovolemia, Sepsis
A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy
This prospective observational study aims to (i) asses intensive care doctors trigger for and the expected physiological response to a fluid bolus and (ii) evaluate the patient's actual physiological response to a single fluid…
- Conditions
- Hypovolemia, Sepsis, Post-operative Hypovolemia, Fluid Therapy
- Trial name
- NCT03178578
- Where
- 3 sites in Australia, Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Breast Neoplasm
Prognostic Value of Circulating Tumor DNA Dosing in Patients in Neoadjuvant Breast Neoplasia
This is a cohort, single-center, prospective study that seeks to analyze the circulating tumor DNA (ctDNA) in patients diagnosed with breast cancer, who will undergo neoadjuvant treatment.
- Trial name
- GIRO_ctDNA (NCT05050890)
- Testing
- ctDNA level during neoadjuvant chemotherapy
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Age-Related Macular Degeneration (AMD)
EarLy Treatment Response in nEoVascular Macular Degeneration With Eylea 8mg: ELEV8 A Prospective Observational Open Label Study Investigating the Fluid Dynamics During Early Response to Aflibercept 8mg in Patients With Exudative Age-related Macular Degeneration (AMD).
This prospective, observational, open-label study evaluates early treatment response to intravitreal aflibercept 8 mg in patients with exudative age-related macular degeneration.
- Trial name
- ELEV8 (NCT07434713)
- Testing
- treatment with Aflibercept 8mg (Eylea)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock
Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?
The main objective of this study is to evaluate in a population of patients with septic shock receiving 500 ml crystalloid over 10 minutes, the proportion of patients classified as "responders" to the fluid challenge (increase of…
- Trial name
- FC-Rev (NCT02116413)
- Testing
- Fluid challenge, Cardiac ultrasound
- Where
- 9 sites in France
- Volunteers
- 145 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Volume Assessment
Evaluation of Fluid Infusion With LifeFlow for Patients With Suspected Septic Shock
The LifeFlow rapid infusion device is a handheld manually-operated device that has been shown in early trials to increase the rate of bolus fluid infusion up to 3 times the rate of delivery attributed to conventional rapid…
- Trial name
- NCT03673891
- Testing
- Life Flow
- Sponsor
- University of Arizona
Normal Pressure Hydrocephalus
Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or…
- Trial name
- NCT01618500
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Nervous System Diseases
Cerebrospinal Fluid Collection and Repository Storage
Background: Cerebrospinal fluid (CSF) is the liquid around the brain and spinal cord. Many diseases can only be diagnosed by examining the CSF. A lumbar puncture is used to collect and test CSF.
- Trial name
- NCT01862107
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)