Clinical trials: Fluid Response
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
IVF, Pregnancy
Evaluation of the Relationship Between Oxidative Stress and Human Reproduction
The aim of the study is to investigate the role of oxidative stress in female infertility and the relationship between the stress as it is illustrated by questionnaires, serum markers, follicular fluid markers, and ovarian…
- Conditions
- IVF, Pregnancy, Oxidative Stress, Fertility Disorders
- Trial name
- OxidStressHR (NCT05575739)
- Testing
- Measurement of oxidative stress levels (Malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonylated proteins )
- Where
- Romania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Calla IVF Center
Metabolic Acidosis, CKD
Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.
With this research the investigators want to study how patients with chronic kidney disease respond to different sodium- and potassium salts.
- Conditions
- Metabolic Acidosis, CKD, Electrolyte and Fluid Balance Conditions
- Trial name
- 5S (NCT06237712)
- Testing
- Dietary supplement consisting of 40 mmol/daily of potassium chloride, Dietary supplement consisting of 40 mmol/daily of potassium gluconate, Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Migraine
Tear Biomarkers for Migraine
The goal of this observational monocentric study is to investigate tear and serum biomarkers in patients with migraine compared with healthy controls, and to explore their potential diagnostic, clinical, and predictive value.
- Trial name
- TEAR (NCT07690696)
- Testing
- Patients with migraine
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vegetable Signature Documentation With Metabolomic Technique
Vegetable Signature From Human Metabolomics Responses
The purpose of this study is to perform dietary intervention studies on a variety of vegetables.
- Trial name
- NCT03483558
- Testing
- Control, Spinach, Celery
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Critical Illness
ICU Fluid Utilization Survey in Southeast Asia
The objective of this study is to examine the use of different types of fluids for resuscitation in different phases of fluid management in 3 types of critically ill patients including (1) not bleeding, not septic but need volume…
- Trial name
- Fluid-SEA (NCT06034990)
- Testing
- 10-min online survey
- Where
- Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Pediatric Patients With Hypotension
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) or reduction in sum norepinephrine (NE) equivalent dosing, at Hour 2 after the start of LJPC-501, in pediatric patients…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- NCT03431077
- Testing
- Angiotensin II
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- La Jolla Pharmaceutical Company
Fluid Responsiveness, Hemodynamics
Hemodynamic Evaluation and Fluid Response Observation Through Respiratory Maneuvers
This study evaluates whether respiratory maneuvers can induce measurable hemodynamic changes and whether these changes may be used to assess fluid responsiveness in healthy volunteers.
- Trial name
- HERO (NCT07840040)
- Testing
- Respiratory Maneuvers and Fluid Responsiveness Assessment Protocol
- Where
- Czechia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital Pilsen
Acute Respiratory Distress Syndrome, Sepsis
Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) is a severe condition where severe infection causes fluid accumulation in the lungs, often requiring invasive mechanical ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Hypoalbuminemia
- Trial name
- ALB-SARDS (NCT07857928)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Internal Jugular Vein, Inferior Vena Cava
Internal Jugular Vein and Inferior Vena Cava Collapsibility Indices as a Guidance of Fluid Responsiveness in Septic Shock Cancer Patients
This study aimed to compare between internal jugular vein and inferior vena cava collapsibility indices as a guidance of fluid responsiveness in septic shock cancer patients.
- Conditions
- Internal Jugular Vein, Inferior Vena Cava, Collapsibility Indices, Fluid Responsiveness
- Trial name
- NCT07879287
- Testing
- Ultrasonographic assessment of internal jugular vein (IJV) collapsibility, Ultrasonographic assessment of inferior vena cava (IVC) collapsibility
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Hepatic Carcinoma Malignant Primary Non-Resectable
Liquid Biopsy in Hepatocellular Carcinoma
Circulating tumor DNA (ctDNA) carrying tumor-specific sequence alterations has been found in the cell-free fraction of blood. Hepatocellular carcinoma (HCC) specimens are difficult to obtain, and noninvasive methods are required…
- Trial name
- HCCGenePanel (NCT04111029)
- Testing
- Cell Free DNA
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Glioblastoma, Glioma, Malignant
GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM
The purpose of this study is to better define longitudinal genomic alterations in patients with glioblastoma (GBM), and to determine if plasma circulating tumor DNA (ctDNA) or cell free DNA (cfDNA) is associated with disease…
- Trial name
- NCT05695976
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Sepsis, Septic Shock
Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis
At present, people still have different opinions on choosing which kind of crystalloid solution for patients with sepsis, and there is no unified standard yet.
- Trial name
- NCT04621981
- Testing
- Sodium Bicarbonate Ringer's Solution, Normal Saline
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Xiangya Hospital of Central South University
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Postoperative Complications
Bioelectrical Response to Preoperative Hydration in Colorectal Surgery
This single-center study will evaluate whether short-term changes in bioelectrical impedance measurements after a standardized preoperative intravenous fluid infusion can help predict complications following elective colon or…
- Trial name
- BIA-HYD-CRC (NCT07823530)
- Testing
- Ionolyte Balanced Isotonic Crystalloid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital of Split
Metastatic Colorectal Cancer
lead-in FOLICOLOR Trial: Following Therapy Response Through Liquid Biopsy in Metastatic Colorectal Cancer Patients
Detection of progressive disease by neuropeptide Y (NPY) methylation in liquid biopsies in patients with RAS and BRAF wild-type, unresectable, metastatic colorectal cancer receiving first-line treatment FOLFOX/FOLFIRI and…
- Trial name
- NCT04735900
- Testing
- Liquid biopsy sampling
- Where
- 6 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Antwerp
Sepsis
LifeFlow Sepsis Study
This is a prospective, comparative, blinded, randomized study to prove the safety, efficacy and ease of use of the LifeFlow® device in pediatric patients presenting to an emergency department with concern for sepsis.
- Trial name
- NCT07191054
- Testing
- LifeFlow Rapid infuser, Push Pull
- Where
- United States
- Sponsor
- Phoenix Children's Hospital
Shock, Shock, Septic
Early Initiated Vasopressor Therapy in the Emergency Department
The goal of this pragmatic, multi-center, superiority, randomized clinical trial is to compare early treatment with peripheral (through a vein) infused noradrenaline (a natural hormone that increases blood pressure) with fluid…
- Conditions
- Shock, Shock, Septic, Hypotension, Hypotension and Shock
- Trial name
- VASOSHOCK (NCT05931601)
- Testing
- Noradrenaline
- Where
- 8 sites in Denmark, Sweden
- Volunteers
- 320 people
- Sponsor
- Odense University Hospital
Sepsis, Septic Shock
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality.
- Conditions
- Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload
- Trial name
- TFC-SEPSIS (NCT06572995)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest