Clinical trials: Fluid Response
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Septic Shock, Fluid Resuscitation
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for…
- Conditions
- Septic Shock, Fluid Resuscitation, Crystalloid Solution, Intensive Care Unit
- Trial name
- NCT04449757
- Testing
- Bicarbonated Ringer's solution, Lactated Ringer's solution
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhongnan Hospital
Sepsis
Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients
Correction of arterial hypotension is essential for adequate cellular metabolism. maintaining MAP above a minimum level has been recommended in order to prevent further tissue hypoperfusion and organ dysfunction.Functional…
- Trial name
- NCT03179215
- Testing
- fluid challange
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Cairo University
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Answer ALS: Individualized Initiative for ALS Discovery
Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples (blood and spinal fluid (optional)), and cell lines for ALS gene identification.
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Flail Arm ALS, Progressive Muscular Atrophy
- Trial name
- AnswerALS (NCT02574390)
- Where
- 8 sites in United States
- Volunteers
- 1,049 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
Breast Cancer Female, Stage II Breast Cancer
Predicting BReast cAncer Response to neoadjuVant Therapy by ctDNA Assessment
This is a prospective and observational study, aiming to determine the detection rate and change of CtDNA in blood samples of cancer patients before, during and after neoadjuvant treatment.
- Conditions
- Breast Cancer Female, Stage II Breast Cancer, Stage III Breast Cancer, HER2-positive Breast Cancer
- Trial name
- BRAVA (NCT06087120)
- Where
- 3 sites in Indonesia, Vietnam
- Volunteers
- 125 people
- Sponsor
- Gene Solutions
Non-small Cell Lung Cancer, Colorectal Cancer
SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation
The purpose of SIBYL is to generate clinical validity data for the ability of a future version of Guardant360 developed by Guardant Health to measure response to systemic therapy in patients with unresectable advanced solid…
- Conditions
- Non-small Cell Lung Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT05935384
- Testing
- Guardant360
- Where
- United States
- Volunteers
- 470 people
- Sponsor
- Guardant Health, Inc.
Sepsis, Shock, Septic
"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools"
The mini fluid challenge (mini_FC) is a functional hemodynamic test which has been used in different clinical contexts to assess fluid responsiveness.
- Conditions
- Sepsis, Shock, Septic, Critically Ill
- Trial name
- MINI3 (NCT04934943)
- Testing
- mini_FC
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Humanitas Clinical and Research Center