Clinical trials: Fluid Response
Head and Neck Squamous Cell Carcinoma
Liquid Biopsy in Head and Neck Cancer
Overall survival of patients with head and neck squamous cell carcinoma (HNSCC) remains unsatisfactory due to often advanced clinical stage at diagnosis and high rate of recurrence and second primaries.
- Trial name
- NCT03926468
- Testing
- Liquid biopsy
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Sepsis
Temperature Gradients for Sepsis Severity and Fluid Resuscitation
The assessment and treatment of Septic Shock (SS) is a thorny issue in current care. Fluid resuscitation is one of the key measures for SS treatment.
- Trial name
- sepsis (NCT04068298)
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Severe Sepsis, Septic Shock
The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients
Major microvascular blood flow alterations have been documented in patients with severe sepsis. It was also demonstrated that the microcirculation improved in survivors of septic shock but failed to do so in patients dying from…
- Conditions
- Severe Sepsis, Septic Shock, Microcirculation
- Trial name
- NCT01319630
- Testing
- Sidestream Dark Field (SDF), Near Infrared Spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mercy Research
Influenza
Phase II Study to Investigate the Kinetics of the Immune Response Generated by Influenza Virus Vaccine.
The primary objective of this study was to perform a variety of assays on blood, serum, nasal wash and cell samples obtained from healthy adult subjects for the purposes of developing assays for application in the further…
- Trial name
- NCT00192309
- Testing
- CAIV-T, TIV
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Coronary Surgery
Uncalibrated Pulse Contour to Assess Fluid Responsiveness in Off Pump Cardiac Surgery
The goal of this observational study is to Compare the performance of uncalibrated pulse wave contour analysis compared with transesophageal echocardiography (TEE) to assess response to a vascular filling test during…
- Trial name
- UPC-OPCS (NCT06822361)
- Where
- Reunion
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Septic Shock, Sepsis
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction.
- Trial name
- NCT06461390
- Testing
- Norepinephrine, Ringer's Lactate
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Metastatic Nonsmall Cell Lung Cancer
Predictive Gene Profiles and Dynamic Measurement of Treatment Response in Metastatic Non-small Cell Lung Cancer
The study aims include: Exploring potential predictive molecular profiles to immunotherapy/chemotherapy Investigating the role of circulating tumor DNA as a dynamic biomarker during immunotherapy/chemotherapy Identifying possible…
- Trial name
- NCT03512847
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Zealand University Hospital
Sepsis
A Simple Clinical Tool to Help Assess Patient Volume (Fluid) Status
Patients may have actual or relative intravascular volume depletion in a number of different disease states, particularly with sepsis syndrome.
- Trial name
- NCT00599794
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Septic Shock
High MAP in Septic Shock With Hypertension
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
- Trial name
- NCT01443494
- Testing
- NE
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Influenza
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine(CAIV-T)in Healthy Adults Aged 18 to 59 and Healthy Adults Aged 60 Years and Older
The purpose of this clinical study was to evaluate immune responses measuring antibodies in serum and secretions and cellular immune responses generated by CAIV-T vaccine in healthy adults aged 18 years and older as a means to…
- Trial name
- NCT00192153
- Testing
- CAIV-T or TIV
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypovolemia
Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU
The investigators hypothesize that analysis of blood pressure will allow doctors to predict whether or not blood flow from the heart (cardiac output) increases after intravenous fluids are given.
- Trial name
- NCT02419404
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Septic Shock, Vein Collapsibility
Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination
The study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.
- Conditions
- Septic Shock, Vein Collapsibility, Intravascular Doppler, Volume Responsiveness in Septic Shock
- Trial name
- FRIEND (NCT02676427)
- Testing
- passive leg raising
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Peri-implant Soft Tissue Healing
Soft Tissue Response and IL-1β Levels Around CAD/CAM-Milled vs 3D-Printed PMMA Healing Abutments
This study looked at how the gums and tissues around dental implants heal when using two different types of temporary healing caps made of PMMA (a common dental material).
- Trial name
- NCT07287722
- Testing
- CAD/CAM-Milled PMMA Healing Abutment, 3D-Printed PMMA Healing Abutment
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ali Hassan Eid Toto
Sepsis, Sepsis Bacterial
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
The overall purpose of this study is to demonstrate the usability of a clinical-grade device in the form of a finger clasp similar to a pulse oximeter for monitoring lactate values, by comparing its performance in reading…
- Conditions
- Sepsis, Sepsis Bacterial, Lactate Blood Increase, Infectious Disease
- Trial name
- NCT04796285
- Testing
- Lab Clasp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Orthodontic Tooth Movement
Gingival Crevicular Fluid Cytokine Levels in Response to Orthodontic Forces
The aim of this randomized split-mouth study was to quantify simultaneously 30 analytes including cytokines, chemokines and growth factors in gingival crevicular fluid (GCF) in response to different magnitudes of forces during…
- Trial name
- GCF (NCT03555747)
- Testing
- Canine distalization
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Septic Shock
Utility of Sodium Lactate Infusion During Septic Shock
ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients
- Trial name
- ULIS1 (NCT03528213)
- Testing
- Sodium Lactate light dose, Sodium Lactate high dose, Normal saline
- Where
- 7 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Sepsis
The Effect of CUGP Fluid Management in Patients With Sepsis or Septic Shock
This study aims to assess whether procedural critical ultrasonography guided precise fluid management (CUGP) can affect the clinical fluid management strategy and improve the outcomes of patients with sepsis or septic shock.
- Trial name
- NCT06879249
- Testing
- critical ultrasonography
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shusheng Li