Clinical trials: Fluid Response, open to volunteers
Lung Cancer, Non-Small Cell
Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer
This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer.
- Trial name
- LumenDx (NCT06963307)
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- JaxBio Ltd
Sepsis
Early Vasopressors in Sepsis
Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body's tissues and organs.
- Trial name
- EVIS (NCT05179499)
- Testing
- Norepinephrine, Balanced Crystalloid
- Where
- 25 sites in United Kingdom
- Volunteers
- 1,006 people
- Sponsor
- NHS Greater Glasgow and Clyde
Skin Massage
Exploring the Cutaneous Immune Response to Skin Massage in Early Life
This project aims to study whether regular skin massage in babies induces cutaneous inflammation and whether this inflammatory response is amplified in those receiving daily (vs bi-weekly or no) skin massage over an 8 week…
- Trial name
- CUTIE (NCT07228728)
- Testing
- Skin Massage with Product
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- King's College London
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Migraine
Tear Biomarkers for Migraine
The goal of this observational monocentric study is to investigate tear and serum biomarkers in patients with migraine compared with healthy controls, and to explore their potential diagnostic, clinical, and predictive value.
- Trial name
- TEAR (NCT07690696)
- Testing
- Patients with migraine
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Hepatitis b, Viremia
Adaptability of an Undetectable = Untransmissible Model for HBV
Persons with chronic hepatitis B (HBV) infection and active viremia are infectious and may transmit virus to others through blood/body fluid exposure.
- Trial name
- NCT07449091
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Non-small Cell Lung Cancer, Colorectal Cancer
SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation
The purpose of SIBYL is to generate clinical validity data for the ability of a future version of Guardant360 developed by Guardant Health to measure response to systemic therapy in patients with unresectable advanced solid…
- Conditions
- Non-small Cell Lung Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT05935384
- Testing
- Guardant360
- Where
- United States
- Volunteers
- 470 people
- Sponsor
- Guardant Health, Inc.
Septic Shock, Fluid Resuscitation
Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis
A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.
- Trial name
- FRESHLY (NCT05453565)
- Testing
- Vasopressors, Fluids
- Volunteers
- 7,838 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Colorectal Neoplasms
Prospective Multicenter Cohort Study of Clinical and Molecular Biomarkers in Colorectal Cancer
This prospective, multicenter observational study aims to identify clinical and molecular biomarkers associated with treatment response, disease recurrence, progression, and survival in patients with colorectal cancer (CRC).
- Trial name
- NCT07913802
- Where
- 4 sites in Austria
- Volunteers
- 200 people
- Sponsor
- Vorarlberg Institute for Vascular Investigation and Treatment
Ovarian Neoplasms, Ovarian Cancer
OveRcoming immunosupprEssion aNd rebAlancing the Immune reSponSe in ovAriaN CancEr Study
Ovarian cancer (OC) is one of the most lethal cancers in the world due to late-stage disease at diagnosis. Standard therapy consists of debulking surgery and chemotherapy.
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Ovarian Carcinoma, Immune Suppression
- Trial name
- RENAISSANCE (NCT06611072)
- Testing
- Bone marrow aspiration, Vena puncture, Peritoneal fluid
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gynaecologisch Oncologisch Centrum Zuid
Knee Osteoarthritis
Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
The goal of this clinical trial is to learn if genicular artery embolization (GAE) can improve knee pain and decrease inflammation in adults with knee osteoarthritis.
- Trial name
- GAE-KOA (NCT06940479)
- Testing
- GAE procedure
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Sepsis, Shock, Septic
"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools"
The mini fluid challenge (mini_FC) is a functional hemodynamic test which has been used in different clinical contexts to assess fluid responsiveness.
- Conditions
- Sepsis, Shock, Septic, Critically Ill
- Trial name
- MINI3 (NCT04934943)
- Testing
- mini_FC
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Humanitas Clinical and Research Center
Primary Central Nervous System Lymphoma
Rapid Diagnosis and Treatment Response Monitoring of Primary CNS Lymphoma Using CSF ctDNA Liquid Biopsy
The incidence of primary central nervous system lymphoma (PCNSL) has increased steadily, and the disease often progresses rapidly, with many patients presenting in critical condition.
- Trial name
- NCT07851363
- Testing
- HD-MTX-based chemotherapy, BTK inhibitor
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiaohui Ren
Lung Neoplasms, Neoadjuvant Therapy
MRD-Guided Postoperative Surveillance and Adaptive Treatment for Resectable Lung Cancer
This study is a prospective single-arm clinical trial targeting patients with stage IB-IIIA non-small cell lung cancer (NSCLC) who have received neoadjuvant immunotherapy.
- Conditions
- Lung Neoplasms, Neoadjuvant Therapy, Immunotherapy, Minimal Residual Disease
- Trial name
- NCT07894458
- Testing
- Adaptive therapy of de-escalation and escalation based on MRD testing and pathological response
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Septic Shock
Comparison Between Using Cardiometry and IVC Collapsibility
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Septic shock, a severe form of sepsis, is characterized by persistent hypotension and cellular/metabolic…
- Trial name
- NCT07411469
- Testing
- Cardiometry
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Sepsis, Septic Shock
Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients
This prospective, randomized, controlled trial aimed to evaluate whether fluid resuscitation guided by the Peripheral Perfusion Index (PPI) could reduce the incidence of Acute Skin Failure (ASF) in elderly critically ill…
- Conditions
- Sepsis, Septic Shock, Acute Skin Failure
- Trial name
- PPI-PROTECT (NCT07367113)
- Testing
- Peripheral Perfusion Index-guided Fluid Resuscitation Protocol, Conventional Goal-Directed Fluid Resuscitation
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ying Wang
Venous Congestion, Microcirculation
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
- Conditions
- Venous Congestion, Microcirculation, Volume Expansion
- Trial name
- MICRO-CONGEST (NCT07499401)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock, Pediatric Critical Illness
Randomized Control Study in REsuscitation of SEpsis Trial
Crystalloids vs. Synthetic Plasma for Fluid Resuscitation in Children with Sepsis - REsuscitation of SEpsis Trial (RESET): A Comparative and Feasibility Study This research study, called the REsuscitation of SEpsis Trial (RESET)…
- Trial name
- RESET (NCT07035509)
- Testing
- Pharmaceutical fresh frozen plasma, Normal Saline, Ringer lactate (RL)
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología