Clinical trials: Fluid Therapy
Type 2 Diabetes Mellitus, Obesity
Form of Dairy Products on Satiety, Food Intake and Post-meal Glycaemia in Young and Older Adults
The proposed study is planned to determine the potential role for regular fat dairy products in short-term metabolic control in younger and older adults and the metabolic flexibility in response to food components, which are…
- Trial name
- NCT02491801
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Exposure to Toxins from Smoking, Female Infertility
Presence of Toxins from Smoking in the Follicular Fluid of Women Undergoing Intracytoplasmic Sperm Injection Treatment
Smoking is associated with many adverse health effects like circulatory disorders, pulmonary diseases or heart diseases. It was also shown that smoking correlates with a significantly higher risk for miscarriage, preterm birth or…
- Trial name
- NCT03414567
- Where
- Germany
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Perioperative Fluid Management
Comparison of Hemodynamic Results of Two Different Fluid Managements
In the reduction mammoplasty operations performed in the Plastic and Reconstructive surgery operating room in our clinic, the female patient group, who does not have co-morbidities and does not exceed middle age, is followed by…
- Trial name
- NCT05733403
- Testing
- isotonic solution, Noradrenaline
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Age Related Macular Degeneration
A Pilot Study to Evaluate the Role of High-dose Ranibizumab (2.0mg) in the Management of AMD in Patients With Persistent/Recurrent Macular Fluid Less Than 30 Days Following Treatment With Intravitreal Anti-VEGF Therapy (the LAST Study)
This is a single-masked study to compare intravitreally administered 0.5 mg ranibizumab to 2.0 mg ranibizumab in subjects who manifest persistent or recurrent macular fluid less than 30 days following treatment with intravitreal…
- Trial name
- LAST (NCT01115556)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Periodontal Diseases, Periodontitis
The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.
Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process.
- Trial name
- NCT04404335
- Testing
- Crevicular fluid analysis by using ELISA testing.
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
One-Piece Dental Implant, Bone-Level Implant
Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants
The goal of this clinical study was to learn whether the design of a dental implant affects how the gums around it respond to treatment of peri-implant mucositis, an early and reversible inflammation of the soft tissue around a…
- Conditions
- One-Piece Dental Implant, Bone-Level Implant, Two-Piece Dental Implant, Nonsurgical Mechanical Debridement
- Trial name
- 1PvsBL (NCT07892313)
- Testing
- Nonsurgical Mechanical Debridement With 1% Chlorhexidine Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cuneyt Asim Aral
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Aggressive Periodontitis
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals.
- Trial name
- NCT05297084
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Intracranial Hypertension
CSF Biomarkers in Idiopathic Intracranial Hypertension
Aim of the study is to high lighten the rule of CSF biomarkers in early diagnosis of IIH and in follow up to reach to a definite clinically based decision if this patient will improved on medical treatment or that patient is in…
- Trial name
- NCT05647837
- Testing
- lumper puncture
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Periodontitis
Glucosamine Periodontal Adjunctive Therapy
This study is the first evidence based work evaluated the systemic use of glucosamine as an adjunctive therapy to closed mechanical debridement in chronic periodontitis.
- Trial name
- NCT02214095
- Testing
- glucosamine sulphate, lactose capsules
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Medication Errors
Improving Parental Understanding of Medication Instructions Through a Pictogram-Based Intervention
Liquid medication administration errors are common, and place children at risk for adverse events. Caregivers with low socioeconomic status (SES), low education and poor health literacy skills are at increased risk for errors.
- Trial name
- NCT00537433
- Testing
- Pictogram
- Where
- United States
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Crowding, Tooth
The Effects of Ibuprofen and Laser on Orthodontic Pain
Early orthodontic pain is usually caused by the insertion of elastomeric separators to the mesial and distal of the tooth to be banded in order to create adequate space for proper placement.
- Trial name
- NCT04070001
- Testing
- 400 Mg Ibuprofen, laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeşim KAYA
Fluid Reponsiveness, Fluid Resuscitation
Effect of Colloids Versus Crystalloids on Heart Mechanics: a Double-blind Cross Over Randomized Trial
The debate over whether to use colloid or crystalloid solutions for fluid resuscitationis still ongoing. Colloid solutions consist of large molecules that generally cannot pass through healthy capillary membranes, whereas…
- Conditions
- Fluid Reponsiveness, Fluid Resuscitation, Fluid Therapy
- Trial name
- NCT06900972
- Testing
- Gelafundin
- Where
- Tunisia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Class I Malocclusion, Other Periodontal Diseases
A Biotype Enhancing Strategy For The Patient Undergoing Accelerated Orthodontics
Numerous treatment protocols geared towards accelerating orthodontic treatment have emerged in the past few years as an appealing alternative for patients and practitioners.
- Conditions
- Class I Malocclusion, Other Periodontal Diseases, Thin Gingival Biotype
- Trial name
- NCT02866929
- Testing
- Decortication, Orthodontics, Mucograft
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University
Abdominal Tumor, Abdominal Infection
Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery
This research will confirm that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new…
- Trial name
- NCT02977429
- Testing
- standardized fluid therapy, conventional fluid therapy
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Chronic Periodontitis, Diabetes Mellitus
Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis
The aim of the present study were 1) to determine the role of these adipokines in the pathogenesis of periodontal disease, inflammation and tissue destruction comparing with gingival crevicular fluid (GCF) levels of TNF-α, which…
- Trial name
- NCT02544347
- Testing
- gingival crevicular fluid, non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London