Clinical trials: Fluid Therapy DURING SURGERY
Scoliosis
Blood and Fluid Management During Scoliosis Surgery
In the present retrospective study, it was hypothesized that application, in scoliosis surgery, of a protocol for blood and fluid management, based on goal directed fluid therapy, cell salvage and tranexamic acid, could lead to…
- Trial name
- NCT03814239
- Testing
- protocol
- Where
- Greece
- Volunteers
- 35 people
- Sponsor
- George Papanicolaou Hospital
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Breast Surgery
Fluid Infusion During Breast Surgery
The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their…
- Trial name
- NCT00431743
- Testing
- Hydroxyethylstarch 130/0,4, Lactated Ringer's solution
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs)
PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery
Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications.
- Conditions
- Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs), Fluid Over-load
- Trial name
- PRO STRESS (NCT07627360)
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Suez Canal University
Hypotension During Surgery
Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction
Adequate free flap perfusion during Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction surgery requires maintaining blood pressure above 100 mmHg and avoiding excessive fluid administration.
- Trial name
- GDFT DIEP-flap (NCT06080178)
- Testing
- Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group)
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Postoperative Morbidity, Postoperative Mortality
Hemostasis Evolution During Fluid Loading in Abdominal Surgery. Effects of Fluid Choice: Saline Versus Hydroxyethyl Starch (HAEMO Study)
The primary purpose of the study is to evaluate whether the type of fluid (0.9% saline or 6% Hydroxyethyl starch 130/0.4) in the context of an individualized goal-directed fluid therapy is associated with a difference in…
- Conditions
- Postoperative Morbidity, Postoperative Mortality, Hemostasis Change
- Trial name
- HAEMO (NCT03420261)
- Testing
- 0.9% saline, HES 130/0.4
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Clermont-Ferrand
Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy
Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
Introduction Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is considered as the standard of care for the treatment of peritoneal metastases.
- Conditions
- Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy, Intraoperative Care, Fluid Therapy
- Trial name
- ALBUCHIP (NCT06351475)
- Testing
- Intra-operative albumin administration, Control
- Where
- 8 sites in France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemodynamic Instability
Hemodynamic Response During Goal Directed Fluid Therapy in the OR
The purpose of this study is to retrospectively evaluate the hemodynamic response to goal directed fluid therapy fluid during open abdominal surgery where goal directed fluid therapy is a standard of care after establishing a…
- Trial name
- NCT02365688
- Testing
- Initial bolus pre-incision
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medtronic - MITG
Periodontitis, Adult, Periodontal Diseases
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial
Background: To profile gingival crevicular fluid (GCF) β-Catenin, 8-OHdG, and total antioxidants capacity (TAC) in periodontitis patients during healing of periodontal pockets following non-surgical periodontal therapy…
- Trial name
- NCT07596667
- Testing
- scaling and root planing
- Volunteers
- 21 people
- Sponsor
- Zeyad Nazar
Hypovolemia, Organ Dysfunction
Intraoperative Hypovolemia and Fluid Therapy
Postoperative organ dysfunction severely affects the prognosis of surgical patients. Despite several trials evaluating restrictive or liberal fluid strategies, the ideal fluid replacement strategy remains controversial.
- Trial name
- NCT00852449
- Testing
- restrictive and liberal fluid therapy
- Volunteers
- 70 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fluid Overload
Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery
This is a clinical randomised double blinded multicentre trial of two different fluid treatments during colorectal surgery in an enhanced recovery programme A restricted fluid regimen aiming at zero fluid balance and less than…
- Trial name
- NCT03677622
- Testing
- Voluven to near maximal stroke volume of the heart
- Volunteers
- 150 people
- Sponsor
- Holbaek Sygehus
Surgery, Hypovolemic Shock
Kinetics of the Sublingual Microcirculation During Fluid Bolus
Fluid therapy is one of the cornerstones of the treatment of organ failure. The investigators assume that fluid bolus will increase the delivery of oxygen to the cells and resolve the shock.
- Trial name
- NCT02675725
- Testing
- Measurement of sublingual microcirculation with Cytocam-IDF camera
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Frisius Medisch Centrum
Abdominoplasty
Fluid Therapy and Glycocalyx Shedding During Moderate Surgery
Goal-directed fluid therapy is one of the most accepted strategies in intraoperative fluid therapy, although potential fluid overload is a possible drawback.
- Trial name
- NCT05939518
- Testing
- Lactated Ringer's Fluid Bolus Response to Low Urinary Output, Post-Anesthesia Care Unit Lactated Ringer's Fluid Management Protocol
- Where
- Israel
- Volunteers
- 51 people
- Sponsor
- Hadassah Medical Organization
Hemodynamic Instability
Descending Aorta Blood Flow to Guide Fluid Therapy During Surgery
The investigators will perform a clinical observational study of patients undergoing abdominal surgery. The study will be performed at Sykehuset Telemark, Skien.
- Trial name
- NCT05227729
- Testing
- Measurement of blood flow in descending aorta by suprasternal ultrasound Doppler technique, Measurement of blood flow in descending aorta by transoesophageal ultrasound Doppler technique
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sykehuset Telemark
Fluid Therapy DURING SURGERY
Transesophageal Echocardiology Measured Left Ventricular End Diastolic Area As Guide for Fluid Therapy in Major Oncosurgeries
Intraoperative fluid management is pivotal to successful outcome of major oncosurgeries . Adequate volume replacement to achieve optimal cardiac performance is critical to prevent any deleterious consequences of under…
- Trial name
- TEE LVEDA (NCT03853031)
- Testing
- LVEDA cm2 guided intraoperative fluid in TEE /Study Group, CVP guided intraoperative fluid in CVP / Control group
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Acute Kidney Injury
Effects of Intraoperative Fluid Therapy on Acute Kidney Injury After Thoracoscopic Lobectomy
Background: Acute kidney injury (AKI) often occurs after thoracoscopic lobectomy in high risk patients. Insufficient intraoperative infusion is risk factor of AKI.
- Trial name
- NCT04302467
- Testing
- fluid therapy during operation
- Where
- China
- Volunteers
- 276 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Critical Illness
Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery
We hypothesize that measurements of interstitial fluid (ISF) glucose by the FreeStyle Navigator (Abbot Diabetes Care), a continuous glucose monitoring system, will correlate with blood glucose (BG) values in surgical and ICU…
- Trial name
- NCT00694473
- Testing
- Freestyle Navigator
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Liver Surgery
Restrictive vs Goal Directed Fluid Therapy During Hepatobiliary Surgery
"Restrictive" fluid management is usually the current standard practice for patients undergoing liver surgery. The general idea is to maintain a low central venous pressure in order to decrease blood loss and improve the quality…
- Trial name
- NCT04092608
- Testing
- GDFT, LOW CVP (restrictive group)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Erasme University Hospital
Ovarian Neoplasm, Fluid Therapy
Fluid Balance During Surgery for Ovarian Cancer
Extensive tumour debulking challenges both surgeon and anaesthesiologist but promotes survival in late-stage ovarian cancer patients.
- Trial name
- NCT03006939
- Testing
- Cytoreductive surgery
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bonn
Colorectal Cancer, Urologic Cancer
Fluid Challenge and Plasma Volume, During Surgery
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique.
- Conditions
- Colorectal Cancer, Urologic Cancer, Gynecologic Cancer, Colorectal Disorders
- Trial name
- FC-VE (NCT05726136)
- Testing
- acetated Ringers, albumin 5%, albumin 20%
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Joachim Zdolsek