Clinical trials: Fluid and Electrolyte Imbalance
Dehydration
IV NaCl (Sodium Chloride) 0.9% Vs (Versus) IV NaCl 0.9% + 5% Dextrose in Pediatric ER for Dehydration
Dehydration and refusal to eat and drink are common complaints in the Pediatric ED (Emergency Department). Most of these children have had an unsuccessful trial of oral rehydration in their community service, therefore are…
- Trial name
- NCT02054585
- Testing
- NaCl 0.9%, NaCl 0.9 +5% dextrose
- Where
- Israel
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Hypotension on Induction
Anesthesia-induced Hypotension and Fluid Responsiveness
The purpose of this study is to find out which of the variables related to fluid responsiveness (e. g., perfusion index [PI], pleth variability index [PVI], pulse oximetry plethysmographic variance [ΔPOP]) can best predict…
- Trial name
- PVI (NCT03439007)
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Seoul National University Hospital
Dehydration
Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)
The purpose is to characterize the in-line pressure profiles associated with several infusion technique factors during subcutaneous (SC) infusion of Lactated Ringer's solution, preceded by recombinant human hyaluronidase…
- Trial name
- INFUSE-AT1A (NCT01116102)
- Testing
- Subcutaneous HYLENEX (recombinant human hyaluronidase) and Lactated Ringer's solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Dehydration, Rehydration
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Dehydration lowers both physical and mental performance if it is severe enough. Performance declines are more pronounced in hot conditions or after prolonged strenuous activity such as exercise.
- Conditions
- Dehydration, Rehydration, Exercise Performance, Exercise Recovery
- Trial name
- NCT05428761
- Testing
- TP1, TP2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.
Hyponatremia
Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children
In children fluids are supplemented during surgery to provide volume, to maintain blood glucose levels, electrolyte balance and to meet the ongoing fluid losses during surgery.
- Trial name
- NCT02936167
- Testing
- Ringer Lactate, Plasmalyte
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Dehydration in Children, Fluid Therapy
Boluses of Ringer's in Surgical Kids (BRiSK Study)
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar.
- Trial name
- BRiSK (NCT05285371)
- Testing
- Urinalysis (UA), Complete Metabolic Panel (CMP), Glucose Stick Test (d-Stick)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Dehydration
IV Glucose for Dehydration Treatment
To determine whether the addition of dextrose to IV fluids in the treatment of gastroenteritis leads to a decrease in serum ketones.
- Trial name
- NCT01285713
- Testing
- 5% Dextrose (D5) in Normal Saline (NS), Normal Saline (NS)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Dehydration (Physiology)
Rehydration With a Trace Mineral Supplement
It is well established that post-exercise rehydration with electrolyte solutions is more effective than plain water. However, most commercially available drinks are high in electrolytes but lack some essential trace minerals.
- Trial name
- TRACE (NCT06858904)
- Testing
- ConcenTrace, ZeroLyte
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Intravenous Fluids, Fluid and Electrolyte Imbalance
SOFI: A Quality Improvement Project to Standardize Use of Intravenous Fluids in Hospitalized Pediatric Patients
Intravenous fluids (IVF) are used in hospitalized patients to replenish the fluid and electrolyte losses of patients who cannot take adequate hydration by mouth or through their gut.
- Conditions
- Intravenous Fluids, Fluid and Electrolyte Imbalance, ADH Inappropriate
- Trial name
- SOFI (NCT03924674)
- Testing
- Education, clinical decision support tools
- Where
- 89 sites in United States
- Volunteers
- 106 people
- Sponsor
- Seattle Children's Hospital
Dehydration
Kinetic Method to Detect Dehydration
1. The distribution and elimination of infusion fluids can be studied by volume kinetics, a mathematical method based on serial analysis of the blood hemoglobin concentration. 2.
- Trial name
- NCT01062776
- Testing
- Dehydration
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sodertalje Hospital
Metabolic Acidosis, CKD
Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.
With this research the investigators want to study how patients with chronic kidney disease respond to different sodium- and potassium salts.
- Conditions
- Metabolic Acidosis, CKD, Electrolyte and Fluid Balance Conditions
- Trial name
- 5S (NCT06237712)
- Testing
- Dietary supplement consisting of 40 mmol/daily of potassium chloride, Dietary supplement consisting of 40 mmol/daily of potassium gluconate, Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Fluid Retention, Fluid Loss
The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration
The purpose of this research study is to evaluate the effects of a topical sodium bicarbonate lotion on physiological and psychological responses associated with hydration status and fluid balance in humans during passive heat…
- Conditions
- Fluid Retention, Fluid Loss, Sodium Retention, Cognitive Change
- Trial name
- AMPlify (NCT04598386)
- Testing
- PR Lotion - AMP Human Performance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Dehydration
Efficacy and Time and Resources for Hylenex-facilitated SC Rehydration Versus ORT for Dehydrated Children in the Emergency Department (ED)
The purpose is to evaluate the safety and efficacy as well as the time and resources needed in the ED setting to achieve rehydration in young pediatric subjects with mild to moderate dehydration using hylenex-facilitated SC…
- Trial name
- INFUSE-TM (NCT01120431)
- Testing
- Oral rehydration fluid, Isotonic hydration fluid and recombinant human hyaluronidase
- Sponsor
- Baxter Healthcare Corporation
Anesthesia, Fluid and Electrolyte Imbalance
Pressure Analysis of Trendelenburg Position Effect on Indices From Arterial Pressure
Intraoperative fluid management is key component of care for patients undergoing surgery. Hypovolemia and hypervolemia both associate with increased morbidity, length of stay in the intensive care unit and mortality.
- Conditions
- Anesthesia, Fluid and Electrolyte Imbalance, Hemodynamic Instability
- Trial name
- NCT05558826
- Testing
- HemoSphere advanced monitoring platform with Acumen Hypotension Prediction Index Software
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Kidney Injury
A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney Injury
Acute Kidney Injury (AKI) is the sudden and recent reduction in kidney function. This can be detected by measuring a rise in blood creatinine level or from a reduction in urine.
- Trial name
- NCT05538351
- Testing
- Body Composition Monitor (BCM)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Hertfordshire
Pulmonary Edema, Acute Lung Injury
Fluid Management in the Post-Anesthetic Care Unit (PACU) at Sourasky Medical Center
Peri-operative fluid therapy is a controversial area with few randomized trials to guide practice. Fluid management has a significant influence on outcome following surgery.
- Conditions
- Pulmonary Edema, Acute Lung Injury, Hypertension, Renal Failure
- Trial name
- NCT00995228
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hyponatremia, Pituitary Surgery
Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery
The investigators are conducting this study to investigate new preventive measures for patients with low sodium levels (hyponatremia), which can occur after surgery on the pituitary gland.
- Trial name
- TREASURE-PIT (NCT07273630)
- Testing
- Fluid restriction, Dietary protein supplementation, Standard post-operative care
- Where
- Switzerland
- Volunteers
- 282 people
- Sponsor
- University Hospital, Basel, Switzerland
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyponatremia With Normal Extracellular Fluid Volume
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia
The present study is designed to confirm and extend the observation from previous studies that lixivaptan therapy corrects hyponatremia, in euvolemic subject, including subjects with SIADH.
- Trial name
- NCT00660959
- Testing
- lixivaptan
- Where
- 71 sites in United States, Belgium and 4 more
- Volunteers
- 106 people
- Sponsor
- CardioKine Inc.
Hyponatremia, Surgery
Fluid Tonicity and Hyponatraemia Post Surgery
Retrospective audit of adult patients who underwent major surgery in our institution, and biochemical outcomes including hyponatremia, in relation to the maintenance fluid tonicity administered peri-operatively.
- Conditions
- Hyponatremia, Surgery, Fluid and Electrolyte Imbalance
- Trial name
- NCT03840629
- Testing
- No study intervention.
- Volunteers
- 659 people
- Sponsor
- National University Hospital, Singapore